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This is LuaHBTeX, Version 1.22.0 (TeX Live 2025) (format=lualatex 2025.11.6) 12 FEB 2026 11:33
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Underfull \hbox (badness 1755) in paragraph at lines 135--135
[]\TU/CharisSIL(1)/m/n/8 In mice and rat mod-els of COPD, var-i-ous flavonoids
have
[]
Underfull \hbox (badness 1028) in paragraph at lines 135--135
\TU/CharisSIL(1)/m/n/8 like-wise been proved to in-hibit the de-vel-op-ment of
COPD by
[]
Underfull \hbox (badness 1596) in paragraph at lines 135--135
\TU/CharisSIL(1)/m/n/8 In a CS-induced mouse model, isoliquir-it-i-genin re-duce
d MDA
[]
Underfull \hbox (badness 2799) in paragraph at lines 135--135
\TU/CharisSIL(1)/m/n/8 lev-els by en-hanc-ing the ex-pres-sion of Nrf2 and HO-1 [][[]32[]][].
[]
Underfull \hbox (badness 1342) in paragraph at lines 135--135
\TU/CharisSIL(1)/m/n/8 en-zymes such as SOD, GSH [][[]48[]][]. Epi-cat-e-chin re
-pressed the
[]
Underfull \hbox (badness 1097) in paragraph at lines 139--139
\TU/CharisSIL(1)/m/n/8 cor-re-la-tion with the sever-ity of air-flow ob-struc-ti
on. Harm-ful
[]
Underfull \hbox (badness 2707) in paragraph at lines 139--139
\TU/CharisSIL(1)/m/n/8 sub-stances in-duce the res-pi-ra-tory tract ep-ithe-lium
to se-crete
[]
Underfull \hbox (badness 4981) in paragraph at lines 139--139
[]\TU/CharisSIL(1)/m/n/8 [[]101[]][]. IL-6 ac-ti-vates neu-trophils, re-leas-ing
NE and ROS,
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 7631) in paragraph at lines 140--140
\TU/CharisSIL(1)/m/n/8 in-flam-ma-tory dis-eases, ef-fec-tively in-hibit-ing the
on-set and
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
[4
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s
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Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
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cript=latn;language=dflt;"!
Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
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cript=latn;language=dflt;"!
] [5<./image/image-60721.png>]
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL Bold:mode=no
de;script=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL Bold:mode=no
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 1831) in paragraph at lines 141--141
[]\TU/CharisSIL(0)/b/n/8 Tar-get-ing NF-κ󰀀B path-way. \TU/CharisSIL(1)/m/n/
8 The ac-ti-va-tion of the NF-κ󰀀B
[]
Underfull \hbox (badness 2772) in paragraph at lines 141--141
\TU/CharisSIL(1)/m/n/8 path-way is be-lieved to play a piv-otal role in in-flam-
ma-tory
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 3049) in paragraph at lines 148--148
\TU/CharisSIL(1)/m/n/8 mod-u-late NF-κ󰀀B sig-nalling in COPD, ac-knowl-edg-i
ng NF-κ󰀀B’s
[]
Underfull \hbox (badness 1776) in paragraph at lines 148--148
\TU/CharisSIL(1)/m/n/8 p-p65 but in-creas-ing Nrf2 in LPS-induced BEAS-2B cell
[][[]52[]][].
[]
Underfull \hbox (badness 1303) in paragraph at lines 148--148
\TU/CharisSIL(1)/m/n/8 pro-duc-tion and in-flam-ma-tion me-di-a-tor lev-els (COX
-2, NADPH
[]
Underfull \hbox (badness 1783) in paragraph at lines 148--148
\TU/CharisSIL(1)/m/n/8 ox-i-dase 4 (NOX4), NOS2, IL-6 and IL-8) by sup-press-ing
the
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 1221) in paragraph at lines 149--149
\TU/CharisSIL(1)/m/n/8 of in-flam-ma-tory cells and pro-inflammatory cy-tokines such as
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 1348) in paragraph at lines 151--151
\TU/CharisSIL(1)/m/n/8 in the COPD co-infection model. Upon stim-u-la-tion, myel
oid
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 1540) in paragraph at lines 151--151
\TU/CharisSIL(1)/m/n/8 COPD rat model, baicalin re-duced TLR2 and TLR4, fol-lowe
d
[]
Underfull \hbox (badness 1902) in paragraph at lines 151--151
\TU/CharisSIL(1)/m/n/8 by low-er-ing MYD88, phos-pho-ry-la-tion of p65, and in-c
reas-ing
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 3803) in paragraph at lines 151--151
[]\TU/CharisSIL(1)/m/n/8 [[]51[]][]. TLRs are cru-cial tar-gets of flavonoids in
in-hibit-ing
[]
[6
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL Bold:mode=no
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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<./image/file_67aee377039e2.jpg>]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 2376) in paragraph at lines 152--152
\TU/CharisSIL(1)/m/n/8 lo-cal-i-sa-tions and func-tions, is the first sir-tuin
that reg-u-lates
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
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Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 2205) in paragraph at lines 153--153
\TU/CharisSIL(1)/m/n/8 through down-regulating air-way in-flam-ma-tory in-fil-tr
a-tion and
[]
Underfull \hbox (badness 1275) in paragraph at lines 153--153
\TU/CharisSIL(1)/m/n/8 de-creas-ing the in-flam-ma-tory fac-tors (the lev-els of
TNF-α and
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 1132) in paragraph at lines 154--154
[]\TU/CharisSIL(1)/m/n/8 To-tal flavonoid ex-tract also has the ef-fect of in-hi
bit-ing the
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 1895) in paragraph at lines 154--154
\TU/CharisSIL(1)/m/n/8 NF-κ󰀀B path-way. For ex-am-ple, to-tal flavonoids fro
m \TU/CharisSIL(0)/m/it/8 Nigella
[]
Underfull \hbox (badness 1642) in paragraph at lines 154--154
\TU/CharisSIL(1)/m/n/8 of neu-trophils and macrophages into the lung and de-crea
sed
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 3219) in paragraph at lines 154--154
\TU/CharisSIL(1)/m/n/8 flavonoids from lo-quat (\TU/CharisSIL(0)/m/it/8 Eri-obot
rya japon-ica\TU/CharisSIL(1)/m/n/8 ) leaves al-le-vi-ated
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 4291) in paragraph at lines 155--155
[]\TU/CharisSIL(0)/b/n/8 Tar-get-ing MAPK path-way. \TU/CharisSIL(1)/m/n/8 MAPKs
rep-re-sent a di-verse
[]
Underfull \hbox (badness 5475) in paragraph at lines 155--155
\TU/CharisSIL(1)/m/n/8 trans-duc-tion path-ways. The MAPK fam-ily com-prises fou
r
[]
Underfull \hbox (badness 2662) in paragraph at lines 155--155
\TU/CharisSIL(1)/m/n/8 sub-fam-i-lies: ex-tra-cel-lu-lar reg-u-lated pro-tein ki
-nases (ERK)1/2
[]
Underfull \hbox (badness 2213) in paragraph at lines 155--155
\TU/CharisSIL(1)/m/n/8 (ex-tra-cel-lu-lar signal-regulated ki-nases 1 and 2), ER
K5, JNKs,
[]
Underfull \hbox (badness 1052) in paragraph at lines 155--155
\TU/CharisSIL(1)/m/n/8 and p38s (p38 MAPKs). No-tably, p38 MAPK is ac-ti-vated
in
[]
Underfull \hbox (badness 1122) in paragraph at lines 156--156
\TU/CharisSIL(1)/m/n/8 the in-hi-bi-tion of the ERK, p38, and JNK sig-nalling pa
th-ways
[]
Underfull \hbox (badness 1253) in paragraph at lines 156--156
[]\TU/CharisSIL(1)/m/n/8 [[]72[]][]. Sily-marin sig-nif-i-cantly al-le-vi-ated
the thick-en-ing of the
[]
[7
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
<./image/file_68999e3c72e62.png>]
Underfull \hbox (badness 1048) in paragraph at lines 157--157
[]\TU/CharisSIL(1)/m/n/8 Bac-te-rial in-fec-tion stands as a pri-mary cul-prit
be-hind acute
[]
Underfull \hbox (badness 1845) in paragraph at lines 157--157
\TU/CharisSIL(1)/m/n/8 al-le-vi-ate the patho-log-i-cal in-flam-ma-tion as-so-ci
-ated with COPD
[]
Underfull \hbox (badness 2277) in paragraph at lines 158--158
\TU/CharisSIL(1)/m/n/8 are es-sen-tial for caus-ing and pro-mot-ing var-i-ous ce
ll growth,
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 3930) in paragraph at lines 159--159
\TU/CharisSIL(1)/m/n/8 re-duced the ex-pres-sion level of MUC5AC by in-hibit-ing
the
[]
Underfull \hbox (badness 1939) in paragraph at lines 159--159
\TU/CharisSIL(1)/m/n/8 ac-ti-va-tion of the EGFR, as ev-i-denced by de-creased
lev-els of
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 2486) in paragraph at lines 159--159
\TU/CharisSIL(1)/m/n/8 tilianin also re-duced MUC5AC ex-pres-sion by mod-u-lat-i
ng the
[]
Underfull \hbox (badness 1107) in paragraph at lines 159--159
\TU/CharisSIL(1)/m/n/8 cells [][[]77[]][]. Fur-ther-more, icariin was shown to
pro-mote lung
[]
Underfull \hbox (badness 1342) in paragraph at lines 161--161
\TU/CharisSIL(1)/m/n/8 and mono-cyte chemo-tac-tic protein-1 lev-els in bron-cho
alve-o-lar
[]
Underfull \hbox (badness 1484) in paragraph at lines 161--161
\TU/CharisSIL(1)/m/n/8 and al-le-vi-ated gob-let cells meta-pla-sia and em-phy-s
e-ma-tous by
[]
Underfull \hbox (badness 3118) in paragraph at lines 161--161
\TU/CharisSIL(1)/m/n/8 cells (such as leuko-cytes, to-tal lym-pho-cytes, CD11b$
[][]$CD11c$[][]$
[]
Underfull \hbox (badness 2393) in paragraph at lines 161--161
\TU/CharisSIL(1)/m/n/8 sig-nal path-ways in the COPD mice model [][[]78[]][]. Gi
nkgetin
[]
Underfull \hbox (badness 1107) in paragraph at lines 161--161
\TU/CharisSIL(1)/m/n/8 path-way in CSE-induced A549 cells, which is as-so-ci-ate
d with
[]
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Underfull \hbox (badness 1292) in paragraph at lines 171--171
\TU/CharisSIL(1)/m/n/8 them, MMPs are a promi-nent and in-flu-en-tial fam-ily.
Tis-sue
[]
Underfull \hbox (badness 1237) in paragraph at lines 171--171
\TU/CharisSIL(1)/m/n/8 of MMPs; usu-ally, TIMP-1 in-hibits ac-tive MMPs, and TIM
P-1
[]
Underfull \hbox (badness 1817) in paragraph at lines 171--171
\TU/CharisSIL(1)/m/n/8 binds to pro-MMP-9 to pre-vent the ac-ti-va-tion of pro-M
MP-9.
[]
Underfull \hbox (badness 1490) in paragraph at lines 173--173
\TU/CharisSIL(1)/m/n/8 as \TU/CharisSIL(0)/m/it/8 α-SMA \TU/CharisSIL(1)/m/n/8
and col-la-gen. This pro-cess al-ters the EMT [][[]119[]][].
[]
Underfull \hbox (badness 1033) in paragraph at lines 174--174
\TU/CharisSIL(1)/m/n/8 im-prov-ing lung func-tion [][[]33[]][]. In four-day CS-e
xposure mice,
[]
[8
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
]
Underfull \hbox (badness 2418) in paragraph at lines 177--177
\TU/CharisSIL(1)/m/n/8 re-sponse of cells to var-i-ous stim-uli, in-clud-ing DNA
dam-age,
[]
Underfull \hbox (badness 1048) in paragraph at lines 178--178
\TU/CharisSIL(1)/m/n/8 apop-to-sis in the patho-gen-e-sis of COPD. For in-stance
, baicalin
[]
Underfull \hbox (badness 1107) in paragraph at lines 178--178
\TU/CharisSIL(1)/m/n/8 apop-to-sis in CSE-treated MLE-12 cells, which are mouse lung
[]
Underfull \hbox (badness 1540) in paragraph at lines 178--178
\TU/CharisSIL(1)/m/n/8 type II ep-ithe-lial cells [][[]66[]][]. Ad-di-tion-ally,
baicalin mit-i-gates
[]
Underfull \hbox (badness 1087) in paragraph at lines 178--178
\TU/CharisSIL(1)/m/n/8 flavonoids reg-u-late autophagy-related apop-to-sis. Puer
-arin has
[]
Underfull \hbox (badness 1521) in paragraph at lines 178--178
\TU/CharisSIL(1)/m/n/8 been demon-strated to in-hibit FUNDC1-mediated mi-to-chon
-drial
[]
Underfull \hbox (badness 1024) in paragraph at lines 178--178
\TU/CharisSIL(1)/m/n/8 Puer-arin also pro-tects lung func-tion and in-hibits apo
p-to-sis by
[]
Underfull \hbox (badness 1521) in paragraph at lines 178--178
\TU/CharisSIL(1)/m/n/8 down-regulating the Bax level and up-regulating Bcl-2 in the
[]
Underfull \hbox (badness 1939) in paragraph at lines 178--178
\TU/CharisSIL(1)/m/n/8 lung, a pro-cess that de-pends on the PINK1-parkin sig-na
lling
[]
Underfull \hbox (badness 1132) in paragraph at lines 179--179
\TU/CharisSIL(1)/m/n/8 Ad-di-tion-ally, acyl-CoA syn-thetase long-chain fam-ily mem-ber 4
[]
Underfull \hbox (badness 2229) in paragraph at lines 180--180
[]\TU/CharisSIL(1)/m/n/8 Scutel-larein may help treat COPD by in-hibit-ing fer-r
op-to-sis
[]
Underfull \hbox (badness 10000) in paragraph at lines 180--180
\TU/CharisSIL(1)/m/n/8 through iron chela-tion and in-ter-ac-tion with the en-zy
me
[]
Underfull \hbox (badness 1389) in paragraph at lines 180--180
\TU/CharisSIL(1)/m/n/8 arachi-do-nate 15-lipoxygenase, which is in-volved in fat
ty acid
[]
Underfull \hbox (badness 2293) in paragraph at lines 180--180
\TU/CharisSIL(1)/m/n/8 lethal small molecule 3-induced fer-rop-to-sis and mi-to-
chon-dria
[]
Underfull \hbox (badness 2753) in paragraph at lines 180--180
\TU/CharisSIL(1)/m/n/8 It no-tably im-peded the in-creas-ing of lipid per-ox-i-d
a-tion and
[]
Underfull \hbox (badness 3343) in paragraph at lines 180--180
\TU/CharisSIL(1)/m/n/8 mor-pho-log-i-cal changes in the mi-to-chon-dria by up-re
gulating
[]
Underfull \hbox (badness 1082) in paragraph at lines 180--180
\TU/CharisSIL(1)/m/n/8 SLC7A11, GPx4, and SOD by down-regulating MDA and ROS
[]
Underfull \hbox (badness 1019) in paragraph at lines 180--180
\TU/CharisSIL(1)/m/n/8 level of CSE-induced alve-o-lar macrophages and in-hib-it
ed lung
[]
Underfull \hbox (badness 1552) in paragraph at lines 180--180
\TU/CharisSIL(1)/m/n/8 by chelat-ing iron and ac-ti-vat-ing the down-stream anti
-oxidant
[]
[9<./image/zipimg67aea6fbb71406.png>]
Underfull \hbox (badness 1430) in paragraph at lines 183--183
\TU/CharisSIL(1)/m/n/8 Flavonoids have a long his-tory of con-sump-tion in di-et
s with
[]
Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 1303) in paragraph at lines 191--191
\TU/CharisSIL(1)/m/n/8 ther-a-peu-tic ef-fects on COPD vary sig-nif-i-cantly. No
-tably, the
[]
Underfull \hbox (badness 1502) in paragraph at lines 191--191
\TU/CharisSIL(1)/m/n/8 num-ber and po-si-tion of hy-droxyl groups in-flu-ence fl
avonoids’
[]
Underfull \hbox (badness 4543) in paragraph at lines 191--191
\TU/CharisSIL(1)/m/n/8 rep-re-sents an-other im-por-tant struc-tural fea-ture th
at im-pacts
[]
Underfull \hbox (badness 2460) in paragraph at lines 192--192
\TU/CharisSIL(1)/m/n/8 cos-met-ics, and health foods, such as ginkgo flavonoids,
tea
[]
Underfull \hbox (badness 2717) in paragraph at lines 193--193
\TU/CharisSIL(1)/m/n/8 which flavonoid is most suit-able for COPD ther-apy re-ma
ins
[]
Underfull \hbox (badness 1107) in paragraph at lines 193--193
\TU/CharisSIL(1)/m/n/8 re-search. Cur-rently, there have been only two clin-i-ca
l tri-als
[]
Underfull \hbox (badness 1132) in paragraph at lines 194--194
\TU/CharisSIL(1)/m/n/8 sources, struc-tural clas-si-fi-ca-tions, and the var-i-o
us mech-a-nisms
[]
Underfull \hbox (badness 5954) in paragraph at lines 201--201
\TU/CharisSIL(1)/m/n/8 of liver fi-bro-sis through PD-1 reg-u-lat-ing NK cell fu
nc-tion
[]
Underfull \hbox (badness 1533) in paragraph at lines 201--201
\TU/CharisSIL(1)/m/n/8 Nat-u-ral Sci-ence Foun-da-tion of Shan-dong Province
“As-tra-galus
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 1527) in paragraph at lines 205--205
[]\TU/CharisSIL(1)/m/n/8 COPD, chronic ob-struc-tive pul-monary dis-ease; CS, ci
garette
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 1418) in paragraph at lines 205--205
\TU/CharisSIL(1)/m/n/8 growth factor-β; IL-6, interleukin-6; IL-1β, interleuki
n-1 beta;
[]
Underfull \hbox (badness 1436) in paragraph at lines 205--205
\TU/CharisSIL(1)/m/n/8 2-related fac-tor 2; CXCL, C-X-C mo-tif chemokine lig-and
; NE,
[]
Underfull \hbox (badness 3375) in paragraph at lines 205--205
\TU/CharisSIL(1)/m/n/8 re-cep-tor 4; JNK, c-Jun N-terminal ki-nase; SOD, su-per-
ox-ide
[]
Underfull \hbox (badness 1796) in paragraph at lines 205--205
\TU/CharisSIL(1)/m/n/8 dis-mu-tase; GSH, glu-tathione; GSH-Px, glu-tathione per-
ox-i-dase;
[]
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Underfull \hbox (badness 2744) in paragraph at lines 205--205
\TU/CharisSIL(1)/m/n/8 ep-ithe-lial cells; TLRs, toll-like re-cep-tors; IRAK, in
terleukin-1
[]
Underfull \hbox (badness 1484) in paragraph at lines 205--205
\TU/CharisSIL(1)/m/n/8 ox-i-dase 4; TIMP, tis-sue in-hibitors of met-al-lo-pro-t
einase; EMT,
[]
Underfull \hbox (badness 2065) in paragraph at lines 207--207
[]\TU/CharisSIL(1)/m/n/8 Shi PL, Zhang GX, Wang PY, Liu ZQ, Zheng BQ. Nat-u-ral
[]
Underfull \hbox (badness 1112) in paragraph at lines 207--207
\TU/CharisSIL(1)/m/n/8 flavonoids for the treat-ment of chronic ob-struc-tive pu
l-monary
[]
[10
Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s
cript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc
ript=latn;language=dflt;"!
]
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[11]
Underfull \hbox (badness 4279) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 causes of death. Cause spe-cific mor-tal-ity 2000–2019.
[]
Underfull \hbox (badness 1642) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Math-ers CD, Lon-car D. Pro-jec-tions of global mor-tal
-ity
[]
Underfull \hbox (badness 1365) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 and bur-den of dis-ease from 2002 to 2030. \TU/CharisSIL
(0)/m/it/8 PLoS Med\TU/CharisSIL(1)/m/n/8 .
[]
Underfull \hbox (badness 10000) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Chris-ten-son SA, Smith BM, Bafad-hel M, et al.
[]
Underfull \hbox (badness 10000) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 Chronic ob-struc-tive pul-monary dis-ease. \TU/CharisSIL
(0)/m/it/8 Lancet\TU/CharisSIL(1)/m/n/8 .
[]
Underfull \hbox (badness 4291) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 treat-ment, pre-ven-tion and dis-ease im-pact. \TU/Chari
sSIL(0)/m/it/8 Respirol-ogy\TU/CharisSIL(1)/m/n/8 .
[]
Underfull \hbox (badness 4981) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 van der Toorn M, Reza-yat D, Kauff-man HF, et al.
[]
Underfull \hbox (badness 10000) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 Lipid-soluble com-po-nents in cigarette smoke in-duce
[]
Underfull \hbox (badness 1231) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 mi-to-chon-drial pro-duc-tion of re-ac-tive oxy-gen speci
es in
[]
Underfull \hbox (badness 1137) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 in-hibitors on air-way mucin: Molec-u-lar in-sight into
the
[]
Underfull \hbox (badness 1062) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 ther-a-peu-tic po-ten-tial tar-get-ing MUC5AC ex-pres-sio
n and
[]
Underfull \hbox (badness 1533) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Shih YM, Chang YJ, Cooke MS, et al. Alky-lat-ing and
[]
Underfull \hbox (badness 1038) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Lee G, Walser TC, Du-bi-nett SM. Chronic in-flam-ma-tio
n,
[]
Underfull \hbox (badness 10000) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 To Y, Ito K, Kizawa Y, et al. Tar-get-ing
[]
Underfull \hbox (badness 2856) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 Phosphoinositide-3-Kinase-δ with Theo-phylline Re-verses
[]
Underfull \hbox (badness 10000) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 Cor-ti-cos-teroid In-sen-si-tiv-ity in Chronic Ob-struc-t
ive
[]
Underfull \hbox (badness 10000) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 Pul-monary Dis-ease. \TU/CharisSIL(0)/m/it/8 Am J Respir Crit Care Med\TU/CharisSIL(1)/m/n/8 .
[]
Underfull \hbox (badness 1552) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Yao HW, Rah-man I. Role of hi-s-tone deacety-lase 2 in
[]
[12]
Underfull \hbox (badness 6125) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Cheng SE, Lee IT, Lin CC, et al. Cigarette smoke
[]
Underfull \hbox (badness 2142) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Brus-selle GG, Joos GF, Bracke KR. New in-sights into
[]
Underfull \hbox (badness 10000) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 met-al-lo-pro-teinases in the de-vel-op-ment of air-way
[]
Underfull \hbox (badness 6001) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 in-flam-ma-tion and re-mod-el-ing. \TU/CharisSIL(0)/m/it
/8 Braz J Med Biol Res\TU/CharisSIL(1)/m/n/8 .
[]
Underfull \hbox (badness 2237) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Burgel PR. Roles of epi-der-mal growth fac-tor re-cep-t
or
[]
Underfull \hbox (badness 4366) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Shao MXG, Nakanaga T, Nadel JA. Cigarette smoke
[]
Underfull \hbox (badness 1603) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 factor-α-converting en-zyme in hu-man air-way ep-ithe-li
al
[]
Underfull \hbox (badness 2608) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 (NCI-H292) cells. \TU/CharisSIL(0)/m/it/8 Am J Phys-iol
Lung Cell Mol Phys-iol\TU/CharisSIL(1)/m/n/8 .
[]
Underfull \hbox (badness 2318) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Chen P, Parks WC. Role of ma-trix met-al-lo-pro-teinase
s
[]
Underfull \hbox (badness 6380) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Al‐Tamari HM, Dabral S, Schmall A, et al. FoxO3
[]
Underfull \hbox (badness 6708) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 an im-por-tant player in fi-bro-ge-n-e-sis and ther-a-peu
-tic
[]
Underfull \hbox (badness 1360) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Wang H, Yang T, Wang T, et al. Phloretin at-ten-u-ates
[]
Underfull \hbox (badness 1755) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 by cigarette smoke. \TU/CharisSIL(0)/m/it/8 Int Im-munoph
ar-ma-col\TU/CharisSIL(1)/m/n/8 . 2018;55:112.
[]
Underfull \hbox (badness 1888) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Birru RL, Bein K, Bon-darchuk N, et al. An-timi-cro-bia
l
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\TU/CharisSIL(1)/m/n/8 and Anti-Inflammatory Ac-tiv-ity of Ap-ple Polyphe-nol
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ript=latn;language=dflt;"!
Underfull \hbox (badness 1418) in paragraph at lines 219--219
[]\TU/CharisSIL(1)/m/n/8 Yu D, Liu X, Zhang G, et al. Isoliquir-it-i-genin In-hi
bits
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\TU/CharisSIL(1)/m/n/8 Cigarette Smoke-Induced COPD by At-ten-u-at-ing
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\TU/CharisSIL(1)/m/n/8 In-flam-ma-tion and Ox-ida-tive Stress via the Reg-u-la-t
ion
[]
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ript=latn;language=dflt;"!
Underfull \hbox (badness 1189) in paragraph at lines 219--219
\TU/CharisSIL(1)/m/n/8 Sup-presses Platelet Ac-ti-vat-ing Factor-Induced Ac-ti-v
a-tion
[]
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[]\TU/CharisSIL(1)/m/n/8 Jin M, Xue C, Wang Y, et al. Pro-tec-tive Ef-fect of
[]
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\TU/CharisSIL(1)/m/n/8 Ob-struc-tive Pul-monary Dis-ease Rats. \TU/CharisSIL(0)
/m/it/8 Chin J In-tegr Med\TU/CharisSIL(1)/m/n/8 .
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[]\TU/CharisSIL(1)/m/n/8 Liu L, Zhang Y, Wang L, et al. Scutel-larein al-le-vi-a
tes
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\TU/CharisSIL(1)/m/n/8 of fer-rop-to-sis by chelat-ing iron and in-ter-act-ing
[]
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\TU/CharisSIL(1)/m/n/8 with arachi-do-nate 15‐lipoxy-ge-nase. \TU/CharisSIL(0
)/m/it/8 Phy-tother Res\TU/CharisSIL(1)/m/n/8 .
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[]\TU/CharisSIL(1)/m/n/8 Gane-san S, Faris AN, Com-stock AT, et al. Quercetin
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\TU/CharisSIL(1)/m/n/8 pre-vents pro-gres-sion of dis-ease in elas-tase/LPS-expo
sed
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[]\TU/CharisSIL(1)/m/n/8 Mi-tani A, Azam A, Vup-pusetty C, et al. Quercetin
[]
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\TU/CharisSIL(1)/m/n/8 re-stores cor-ti-cos-teroid sen-si-tiv-ity in cells from pa-tients
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\TU/CharisSIL(1)/m/n/8 rhinovirus-induced pro-gres-sion of lung dis-ease in mice
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\TU/CharisSIL(1)/m/n/8 Caused by Ex-po-sure to Cigarette Smoke in Male Mice.
[]
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ript=latn;language=dflt;"!
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[]\TU/CharisSIL(1)/m/n/8 Lee S, Ro H, In HJ, et al. Fisetin in-hibits
[]
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ript=latn;language=dflt;"!
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\TU/CharisSIL(1)/m/n/8 and in-flam-ma-tion in Wis-tar rat lungs. \TU/CharisSIL(
0)/m/it/8 J Food Biochem\TU/CharisSIL(1)/m/n/8 .
[]
[13
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ript=latn;language=dflt;"!
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[]\TU/CharisSIL(1)/m/n/8 Chen M, Chen Z, Huang D, et al. Myricetin in-hibits
[]
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\TU/CharisSIL(1)/m/n/8 TNF-α-induced in-flam-ma-tion in A549 cells via
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\TU/CharisSIL(1)/m/n/8 the SIRT1/NF-κ󰀀B path-way. \TU/CharisSIL(0)/m/it/8 Pu
lm Phar-ma-col Ther\TU/CharisSIL(1)/m/n/8 .
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[]\TU/CharisSIL(1)/m/n/8 Lee H, Jung KH, Lee H, et al. Cas-ticin, an ac-tive
[]
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\TU/CharisSIL(1)/m/n/8 com-pound iso-lated from Vi-tex Fruc-tus, ame-lio-rates
the
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\TU/CharisSIL(1)/m/n/8 Dys-func-tion and At-ten-u-ates Ox-ida-tive Stress and
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\TU/CharisSIL(1)/m/n/8 In-flam-ma-tion via In-hi-bi-tion of NF-ĸB in a Chronic
[]
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ript=latn;language=dflt;"!
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[]\TU/CharisSIL(1)/m/n/8 Lu LJ, Tian H, Zheng Y, et al. Ef-fects of cas-ticin on
[]
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\TU/CharisSIL(1)/m/n/8 Lipopolysaccharide-induced BEAS-2B cell dam-age and
[]
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ript=latn;language=dflt;"!
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\TU/CharisSIL(1)/m/n/8 NF-κ󰀀B-KEAP1-NRF2/ARE path-way. \TU/CharisSIL(0)/m/i
t/8 Chin J Im-munol\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Li MF, Wang HF, Lu Y, et al. Lu-te-olin sup-presses
[]
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\TU/CharisSIL(1)/m/n/8 NF‐κ󰀀B sig-nal-ing path-way. \TU/CharisSIL(0)/m/it
/8 Im-mun In-flamm Dis\TU/CharisSIL(1)/m/n/8 .
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[]\TU/CharisSIL(1)/m/n/8 Zhou L, Jian T, Wan Y, et al. Lu-te-olin Al-le-vi-ates
[]
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\TU/CharisSIL(1)/m/n/8 and CYP2A13/NRF2 Sig-nal-ing Path-ways. \TU/CharisSIL(0)
/m/it/8 Int J Mol Sci\TU/CharisSIL(1)/m/n/8 .
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[]\TU/CharisSIL(1)/m/n/8 Luo YL, Zhang CC, Li PB, et al. Naringin at-ten-u-ates
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\TU/CharisSIL(1)/m/n/8 in-duced by cigarette smoke. \TU/CharisSIL(0)/m/it/8 Int Im-munophar-ma-col\TU/CharisSIL(1)/m/n/8 .
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[]\TU/CharisSIL(1)/m/n/8 Chen Z, Wu H, Fan W, et al. Narin-genin sup-presses
[]
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\TU/CharisSIL(1)/m/n/8 BEAS-2B-derived ex-tra-cel-lu-lar vesic-u-lar car-goes di
s-or-der
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[]\TU/CharisSIL(1)/m/n/8 Wang S, He N, Xing H, et al. Func-tion of hes-peridin
[]
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\TU/CharisSIL(1)/m/n/8 al-le-vi-at-ing in-flam-ma-tion and ox-ida-tive stress re
-sponses
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\TU/CharisSIL(1)/m/n/8 of chronic ob-struc-tive pul-monary dis-ease by ac-ti-vat
-ing
[]
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\TU/CharisSIL(1)/m/n/8 Nrf2-mediated path-way. \TU/CharisSIL(0)/m/it/8 Phy-tomed
icine\TU/CharisSIL(1)/m/n/8 . 2022;96:153894.
[]
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[]\TU/CharisSIL(1)/m/n/8 Liu X, Ma Y, Luo L, et al. Tax-i-folin ame-lio-rates
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\TU/CharisSIL(1)/m/n/8 cigarette smoke-induced chronic ob-struc-tive pul-monary
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\TU/CharisSIL(1)/m/n/8 dis-ease via in-hibit-ing in-flam-ma-tion and apop-to-sis
. \TU/CharisSIL(0)/m/it/8 Int
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[]\TU/CharisSIL(1)/m/n/8 Zeng LX, Dong JC, Yu WQ, et al. Baicalin at-ten-u-ates
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ript=latn;language=dflt;"!
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\TU/CharisSIL(1)/m/n/8 and in vitro: A pos-si-ble role for HDAC2 ac-tiv-ity. \T
U/CharisSIL(0)/m/it/8 Int
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[]\TU/CharisSIL(1)/m/n/8 Wang G, Mo-ham-mad-tur-sun N, Lv Y, et al. Baicalin
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\TU/CharisSIL(1)/m/n/8 Ex-erts Anti-Airway In-flam-ma-tion and Anti-Remodelling
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\TU/CharisSIL(1)/m/n/8 ob-struc-tive pul-monary dis-ease through reg-u-la-tion
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\TU/CharisSIL(1)/m/n/8 HDAC2/NF-κ󰀀B/PAI-1 sig-nalling. \TU/CharisSIL(0)/m/i
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[]
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\TU/CharisSIL(1)/m/n/8 miR-4451ef-fect on lipopolysaccharide-induced apop-to-sis
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\TU/CharisSIL(1)/m/n/8 sig-nal-ing path-way. \TU/CharisSIL(0)/m/it/8 J Army Med Univ\TU/CharisSIL(1)/m/n/8 . 2022;44(5):441.
[]
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[]\TU/CharisSIL(1)/m/n/8 Ju J, Li Z, Shi Q. Baicalin In-hibits In-flam-ma-tion
in
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\TU/CharisSIL(1)/m/n/8 TLR2/MYD88/NF-κ󰀀Bp65 Sig-nal-ing Path-way. \TU/Chari
sSIL(0)/m/it/8 Evid Based
[]
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[]\TU/CharisSIL(1)/m/n/8 Jing X, Huo J, Li L, et al. Baicalin Re-lieves Air-way
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[]\TU/CharisSIL(1)/m/n/8 Kim YH, Kang MK, Lee EJ, et al. As-tra-galin In-hibits
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\TU/CharisSIL(1)/m/n/8 Cigarette Smoke-Induced Pul-monary Throm-bo-sis and
[]
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\TU/CharisSIL(1)/m/n/8 cigarette smoke ex-tract. \TU/CharisSIL(0)/m/it/8 Exp The
r Med\TU/CharisSIL(1)/m/n/8 . 2020;20(1):283.
[]
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\TU/CharisSIL(1)/m/n/8 of Icariin Com-bined with No-biletin against Chronic
[]
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\TU/CharisSIL(1)/m/n/8 Ob-struc-tive Pul-monary Dis-eases. \TU/CharisSIL(0)/m/i
t/8 Evid Based Com-ple-ment
[]
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[]\TU/CharisSIL(1)/m/n/8 Li QP, Zhang HY, Yan XP, et al. Up-regulation of
[]
[14
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[]\TU/CharisSIL(1)/m/n/8 Song WY, Song YS, Ryu HW, et al. Tilianin In-hibits
[]
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\TU/CharisSIL(1)/m/n/8 MUC5AC Ex-pres-sion Me-di-ated Via Down-Regulation of
[]
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\TU/CharisSIL(1)/m/n/8 EGFR-MEK-ERK-Sp1 Sig-nal-ing Path-way in NCI-H292
[]
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\TU/CharisSIL(1)/m/n/8 Med-i-ca-tion of Gly-cyrrhiza glabra, Agas-tache ru-gosa
[]
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\TU/CharisSIL(1)/m/n/8 Con-tain-ing Gly-cyrrhizic Acid, Tilianin In-hibits
[]
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\TU/CharisSIL(1)/m/n/8 Neu-trophilic Lung In-flam-ma-tion by Af-fect-ing CXCL2,
[]
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\TU/CharisSIL(1)/m/n/8 biochanin A. \TU/CharisSIL(0)/m/it/8 Eco-tox-i-col En-v-i
-ron Saf\TU/CharisSIL(1)/m/n/8 . 2020;202:110878.
[]
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[]\TU/CharisSIL(1)/m/n/8 Wang L, Jiang W, Wang J, et al. Puer-arin in-hibits
[]
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\TU/CharisSIL(1)/m/n/8 FUNDC1-mediated mi-to-chon-drial au-tophagy and
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\TU/CharisSIL(1)/m/n/8 CSE-induced apop-to-sis of hu-man bronchial ep-ithe-lial
[]
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[]\TU/CharisSIL(1)/m/n/8 Pan XJ, Fan JQ, Xia GQ. Puer-arin in-hibits alve-o-lar
[]
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\TU/CharisSIL(1)/m/n/8 pathway-mediated mi-tophagy. \TU/CharisSIL(0)/m/it/8 Chin
J Patho-phys-iol\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Li XM, Jiang XH, Zeng RH, et al. For-mononetin
[]
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\TU/CharisSIL(1)/m/n/8 at-ten-u-ates cigarette smoke-induced COPD in mice by
[]
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\TU/CharisSIL(1)/m/n/8 sup-press-ing in-flam-ma-tion, en-do-plas-mic retic-u-lum
stress,
[]
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\TU/CharisSIL(1)/m/n/8 and AKT/mTOR sig-nal-ing path-ways. \TU/CharisSIL(0)/m/i
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[]
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[]\TU/CharisSIL(1)/m/n/8 Park JW, Shin NR, Shin IS, et al. Sili-b-inin In-hibits
[]
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[]\TU/CharisSIL(1)/m/n/8 Ko JW, Shin NR, Park SH, et al. Sili-b-inin in-hibits
[]
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\TU/CharisSIL(1)/m/n/8 the fi-brotic re-sponses in-duced by cigarette smoke via
[]
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\TU/CharisSIL(1)/m/n/8 sup-pres-sion of TGF-β1/Smad 2/3 sig-nal-ing. \TU/Chari
sSIL(0)/m/it/8 Food Chem
[]
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[]\TU/CharisSIL(1)/m/n/8 Li DD, Xu D, Wang T, et al. Sily-marin At-ten-u-ates
[]
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\TU/CharisSIL(1)/m/n/8 smoke extract-induced in-flam-ma-tion via si-mul-ta-ne-ou
s
[]
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\TU/CharisSIL(1)/m/n/8 the c/EBPβ sig-nal-ing path-way and CCL2 ex-pres-sion.
\TU/CharisSIL(0)/m/it/8 J
[]
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[]\TU/CharisSIL(1)/m/n/8 Chen XL, Geng DS. Ef-fect of To-tal Flavonoids from
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[]\TU/CharisSIL(1)/m/n/8 Ren QC, Li XH, Li QY, et al. To-tal flavonoids from
[]
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\TU/CharisSIL(1)/m/n/8 sea buck-thorn ame-lio-rates lipopolysac-cha-ride/cigaret
te
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\TU/CharisSIL(1)/m/n/8 smoke‐in-duced air-way in-flam-ma-tion. \TU/CharisSIL(
0)/m/it/8 Phy-tother Res\TU/CharisSIL(1)/m/n/8 .
[]
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\TU/CharisSIL(1)/m/n/8 of To-tal Flavonoids from Scutel-laria Baicalen-sis Georg
i
[]
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\TU/CharisSIL(1)/m/n/8 in the In-flam-ma-tion and Ox-ida-tive Stress in Rats wit
h
[]
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\TU/CharisSIL(1)/m/n/8 Chronic Ob-struc-tive Pul-monary Dis-ease. \TU/CharisSIL
(0)/m/it/8 Chin Pharm\TU/CharisSIL(1)/m/n/8 .
[]
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ll Biol\TU/CharisSIL(1)/m/n/8 . 2007;8(1):49.
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