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HTML
757 lines
70 KiB
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<span leaf="">点击左上角“</span><strong><span leaf="">TMR Publishing Group</span></strong><span leaf="">”关注我们，为您推送更多最新资讯。</span>
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<strong><span leaf="">文章导读</span></strong>
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<strong><span leaf="" style="word-break: break-word;word-break: keep-all; width: 500px;text-align: center;">Research of the molecular mechanism of Hai Honghua medicinal liquor in the treatment of fracture bas</span></strong>
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<span style="letter-spacing:0.7px;"><span leaf=""><br/></span></span>
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<strong><span style="letter-spacing: 0.7px;line-height: 1.5em;"><span leaf="" style="word-break: break-word;word-break: keep-all; width: 700px;text-align: center;">基于网络药理学结合分子对接的海红花药酒治疗骨折的分子机制研究</span></span></strong>
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<img src="http://mmbiz.qpic.cn/mmbiz_jpg/QHFVW13lONaQJxK9QbHU9CtrvTS2ModZx7PibEic5ZQ4cCH8lWDwicMOT5nkdZSXaibDA5W3BIJczbAjAAT7TTibp6A/0?wx_fmt=jpeg" style="width:965px;height: 540px;" data-width="100%" data-imgfileid="100016608"/>
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<span leaf="">本期编辑荐读为您精选</span><span style="color:#007aaa;"><em><span leaf="">Integrative Medicine Discovery</span></em></span><span leaf="">期刊发表的优质文章，通讯作者为上海中医药大学跨学科整合医学研究所, 中国上海, 201203 ZhangHong。<span textstyle="" style="font-weight: bold;">研究涵盖了网络药理学、分子对接等方法，探索海红花药酒治疗骨折的分子机制。</span>希望能为相关领域的学者提供参考和新的思路。</span>
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<span leaf=""><br/></span>
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<span leaf="">海红花药酒（HHML），一种由19种中药组成的著名院内配方，已成功应用于治疗软组织损伤、闭合性新鲜骨折、骨折愈合后肢体功能障碍、肩颈腿痛、膝关节痛等多种临床疾病30年。然而，其在骨折愈合相关疾病治疗中的物质基础研究仍存在空白。因此，探索HHML的活性成分、核心靶点和潜在药理机制以促进骨折愈合尤为重要。研究通过多个数据库筛选出249种HHML生物活性成分和325个HHML-骨折相关靶点。网络分析揭示了槲皮素、木犀草素、山奈酚、甘草查尔酮A、柚皮素和8-异戊烯基山奈酚可能是潜在候选药物，PI3K-AKT信号通路可能在HHML治疗骨折中起重要作用。分子对接表明8-异戊烯基山奈酚、甘草查尔酮A和柚皮素分别与AKT1、PIK3CA和ESR1结合，表现出更低能量和更稳定的特性。结论显示HHML治疗骨折的潜在活性成分、靶蛋白和分子机制，为下一步研究HHML配方的作用机制提供了确切思路。</span>
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<img src="http://mmbiz.qpic.cn/mmbiz_png/QHFVW13lONaQJxK9QbHU9CtrvTS2ModZ2yR72almzo4CzxbFLcRw2LxVUps2WnXE2QEN5xibt0icNYFxBgOicqhtg/0?wx_fmt=png" style="width: 100%;" data-width="100%" data-imgfileid="100016606"/>
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<span leaf="">识别二维码，</span>
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<span leaf="">进入期刊主页。</span>
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<strong><span leaf="">Part 01</span></strong>
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<strong><span leaf="">研究背景</span></strong>
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<span style="letter-spacing:0.7px;"><span leaf="">骨折是一种随着社会进步而日益普遍的疾病，常伴有感染、疼痛、畸形愈合、骨不连或愈合延迟等并发症，严重影响患者生活质量。目前的治疗手段存在显著不足，因此骨折治疗是一个紧迫的临床问题。海红花药酒已成功应用于临床30余年，在骨折愈合中具有良好效果。该配方包含19种草药，其中如南五加可调节炎症因子水平，抑制细胞凋亡，并通过激活PI3K/Akt信号通路缓解内皮功能障碍。近年来，网络药理学方法被广泛应用于研究中药配方，预测中药治疗疾病的潜在机制，并为中药活性成分筛选提供参考。</span></span>
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<strong><span leaf="">Part 02</span></strong>
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</p>
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</section>
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</section>
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<strong><span leaf="">研究结果</span></strong>
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<section style="text-align: justify;margin-bottom: unset;">
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||
<p>
|
||
<span leaf="">研究筛选出249种HHML生物活性成分和325个HHML-骨折相关靶点。网络分析揭示槲皮素、木犀草素、山奈酚、甘草查尔酮A、柚皮素和8-异戊烯基山奈酚可能是潜在候选药物。多个靶点包括TP53、MAPK3、STAT3、AKT1、MAPK1、HSP90AA1、ESR1和PIK3CA可能密切相关。PI3K-AKT信号通路可能在HHML治疗骨折中起重要作用。分子对接表明8-异戊烯基山奈酚、甘草查尔酮A和柚皮素分别与AKT1、PIK3CA和ESR1结合，表现出更低能量和更稳定的特性。</span>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<p>
|
||
<span leaf=""><br/></span>
|
||
</p>
|
||
<section style="text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: unset;">
|
||
<section style="display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 0px 0px 8px;border-bottom-color: rgb(246, 234, 218);min-width: 5%;height: auto;margin-bottom: unset;">
|
||
<section style="justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: -10px;">
|
||
<section style="display: inline-block;vertical-align: bottom;width: auto;align-self: flex-end;flex: 0 0 auto;min-width: 5%;height: auto;padding-right: 6px;margin-bottom: unset;">
|
||
<section style="text-align: justify;font-size: 12px;color: rgb(189, 138, 60);margin-bottom: unset;">
|
||
<p>
|
||
<strong><span leaf="">Part 03</span></strong>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
<section style="display: inline-block;vertical-align: bottom;width: auto;min-width: 5%;flex: 0 0 auto;height: auto;align-self: flex-end;border-style: solid;border-width: 0px 0px 0px 1px;border-color: rgb(189, 138, 60);padding-left: 10px;margin-bottom: unset;">
|
||
<section style="text-align: justify;font-size: 17px;margin-bottom: unset;">
|
||
<p>
|
||
<strong><span leaf="">讨论与展望</span></strong>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: 10px;">
|
||
<section style="display: inline-block; width: 100%; vertical-align: top; align-self: flex-start; flex: 0 0 auto; background-position: 5.13023% 14.0373%; background-repeat: repeat; background-size: 3.30194%; background-attachment: scroll; padding: 19px; background-image: url("http://mmbiz.qpic.cn/mmbiz_png/QHFVW13lONaQJxK9QbHU9CtrvTS2ModZfssPs0wTQYhX6ctSiaY1Uck0WTJ1xXZsZlhU05sOjUqFRmLWamH3XKQ/0?wx_fmt=png"); margin-bottom: unset;" data-width="100%">
|
||
<section style="text-align: justify;margin-bottom: unset;">
|
||
<p>
|
||
<span leaf="">研究表明，海红花药酒通过多成分、多靶点、多通路的复杂网络，在骨折愈合中发挥作用。尽管已有初步研究，但现有公共数据库中的信息缺乏时效性和可靠性。因此，需要进行体内动物研究和体外成骨机制研究，以进一步验证研究结果。</span>
|
||
</p>
|
||
<p>
|
||
<span leaf="">现有的网络药理学和分子对接技术为HHML在骨折治疗中的研究提供了良好的基础。未来可通过空间组学等方法进一步探索HHML在骨折治疗中的机制，以便更好地应用于临床。</span>
|
||
</p>
|
||
<p>
|
||
<span leaf=""><br/></span>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<p>
|
||
<span leaf=""><br/></span>
|
||
</p>
|
||
<section style="text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;">
|
||
<section style="display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 0px 0px 8px;border-bottom-color: rgb(246, 234, 218);min-width: 5%;height: auto;margin-bottom: unset;">
|
||
<section style="justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: -10px;">
|
||
<section style="display: inline-block;width: auto;vertical-align: bottom;min-width: 5%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 5px;padding-left: 5px;margin-bottom: unset;">
|
||
<section style="text-align: justify;letter-spacing: 0px;margin-bottom: unset;">
|
||
<p>
|
||
<strong><span leaf="">原文出自 </span><span style="color: #008181;"><em><span leaf="">Integrative Medicine Discovery</span></em></span><span leaf=""> 期刊</span><span leaf=""><br/></span></strong>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: unset;">
|
||
<section style="display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(189, 138, 60);padding: 5px;margin-bottom: unset;" data-width="100%">
|
||
<section style="transform-origin: center center 0px;margin-bottom: unset;transform: scale(0.95);">
|
||
<section style="justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;">
|
||
<section style="display: inline-block;vertical-align: top;width: 30%;border-width: 0px;align-self: flex-start;flex: 0 0 auto;height: auto;margin-bottom: unset;" data-width="30%">
|
||
<section style="text-align: center;margin-right: 0%;margin-left: 0%;line-height: 0;">
|
||
<section style="vertical-align: middle;display: inline-block;line-height: 0;width: 100%;border-color: rgb(30, 30, 30);border-width: 1px;border-style: none;box-shadow: rgb(30, 30, 30) 0px 0px 0px;height: auto;margin-bottom: unset;" data-width="100%">
|
||
<section nodeleaf="">
|
||
<p>
|
||
<img src="http://mmbiz.qpic.cn/mmbiz_png/QHFVW13lONaQJxK9QbHU9CtrvTS2ModZTMc5hfUEBmcnKsOG7chH3D2o2fg1c9Ba2ibtcKbpclgtC5LLoKicGxdQ/0?wx_fmt=png" style="width: 270px;height: 270px;" data-imgfileid="100016609"/>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="text-align: center;font-size: 12px;letter-spacing: 0.7px;line-height: 1.8;margin-bottom: unset;">
|
||
<p>
|
||
<span leaf="">识别二维码，阅读英文原文。</span><span leaf=""><br/></span>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
<section style="display: inline-block;width: auto;vertical-align: middle;padding-left: 5px;border-width: 0px;align-self: center;flex: 100 100 0%;height: auto;margin-bottom: unset;">
|
||
<section style="margin-top: 2px;">
|
||
<section style="font-size: 13px;text-align: justify;padding-right: 5px;padding-left: 5px;letter-spacing: 0px;line-height: 1.6;margin-bottom: unset;">
|
||
<p style="text-align:left;">
|
||
<span style="color: rgba(0, 0, 0, 0.847);font-family: Calibri;font-size: 16px;">
|
||
<span leaf="">Qian D, He CX, Zhang Q, et al. Research of the molecular mechanism of Hai Honghua medicinal liquor in the treatment of fracture based on network pharmacology combined with molecular docking. Integr Med Discov. 2023;7:e23012. doi:10.53388/TMRIM202307012</span>
|
||
</span>
|
||
</p>
|
||
<p style="text-align:left;">
|
||
<span style="color: rgba(0, 0, 0, 0.847);font-family: Calibri;font-size: 16px;"><span leaf=""><br/></span></span>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<p>
|
||
<span leaf=""><br/></span>
|
||
</p>
|
||
<section style="text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 10px;">
|
||
<section style="display: inline-block;width: auto;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 0px 0px 8px;border-bottom-color: rgb(246, 234, 218);min-width: 5%;height: auto;margin-bottom: unset;">
|
||
<section style="justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: -10px;">
|
||
<section style="display: inline-block;width: auto;vertical-align: bottom;min-width: 5%;flex: 0 0 auto;height: auto;align-self: flex-end;padding-right: 5px;padding-left: 5px;margin-bottom: unset;">
|
||
<section style="text-align: justify;margin-bottom: unset;">
|
||
<p>
|
||
<strong><span leaf="">通讯作者介绍</span></strong>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: unset;">
|
||
<section style="display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(189, 138, 60);padding: 5px;margin-bottom: unset;" data-width="100%">
|
||
<section style="text-align: center;justify-content: center;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 15px;">
|
||
<section style="display: inline-block;vertical-align: top;width: 25%;align-self: flex-start;flex: 0 0 auto;height: auto;margin-bottom: unset;" data-width="25%">
|
||
<section style="justify-content: center;display: flex;flex-flow: row;margin-bottom: unset;">
|
||
<section style="display: inline-block;width: 90px;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(189, 138, 60);border-radius: 99%;overflow: hidden;padding: 5px;height: auto;margin-bottom: unset;">
|
||
<section style="display: flex;width: 100%;flex-flow: column;margin-bottom: unset;" data-width="100%">
|
||
<section style="z-index: 1;margin-bottom: unset;">
|
||
<section style="line-height: 0;margin-bottom: unset;">
|
||
<section style="vertical-align: middle;display: inline-block;line-height: 0;border-radius: 99%;overflow: hidden;width: 100%;height: auto;margin-bottom: unset;" data-width="100%">
|
||
<section nodeleaf="">
|
||
<p>
|
||
<img src="http://mmbiz.qpic.cn/mmbiz_jpg/QHFVW13lONaQJxK9QbHU9CtrvTS2ModZnUyeAvuVN67t8XP85DxVJwDJf2YxCTalrsr17jS080xM6xQv5yGiaEQ/0?wx_fmt=jpeg" style="width: 100%;" data-width="100%" data-imgfileid="100016618"/>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="display: inline-block;vertical-align: middle;width: 50%;align-self: center;flex: 0 0 auto;height: auto;padding-left: 10px;margin-bottom: unset;" data-width="50%">
|
||
<section style="text-align: justify;margin-bottom: unset;">
|
||
<p>
|
||
<strong><span leaf="">XuChi </span></strong>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: unset;">
|
||
<section style="display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgb(248, 243, 237);padding: 22px;margin-bottom: unset;" data-width="100%">
|
||
<section style="text-align: justify;margin-bottom: unset;">
|
||
<p>
|
||
<span leaf=""></span>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="text-align: left;justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: unset;">
|
||
<section style="display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(189, 138, 60);padding: 5px;margin-bottom: unset;" data-width="100%">
|
||
<section style="text-align: center;justify-content: center;display: flex;flex-flow: row;margin-top: 10px;margin-bottom: 15px;">
|
||
<section style="display: inline-block;vertical-align: top;width: 25%;align-self: flex-start;flex: 0 0 auto;height: auto;margin-bottom: unset;" data-width="25%">
|
||
<section style="justify-content: center;display: flex;flex-flow: row;margin-bottom: unset;">
|
||
<section style="display: inline-block;width: 90px;vertical-align: top;align-self: flex-start;flex: 0 0 auto;border-style: solid;border-width: 1px;border-color: rgb(189, 138, 60);border-radius: 99%;overflow: hidden;padding: 5px;height: auto;margin-bottom: unset;">
|
||
<section style="display: flex;width: 100%;flex-flow: column;margin-bottom: unset;" data-width="100%">
|
||
<section style="z-index: 1;margin-bottom: unset;">
|
||
<section style="line-height: 0;margin-bottom: unset;">
|
||
<section style="vertical-align: middle;display: inline-block;line-height: 0;border-radius: 99%;overflow: hidden;width: 100%;height: auto;margin-bottom: unset;" data-width="100%">
|
||
<section nodeleaf="">
|
||
<p>
|
||
<img src="http://mmbiz.qpic.cn/mmbiz_jpg/QHFVW13lONaQJxK9QbHU9CtrvTS2ModZnUyeAvuVN67t8XP85DxVJwDJf2YxCTalrsr17jS080xM6xQv5yGiaEQ/0?wx_fmt=jpeg" style="width: 100%;" data-width="100%" data-imgfileid="100016618"/>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="display: inline-block;vertical-align: middle;width: 50%;align-self: center;flex: 0 0 auto;height: auto;padding-left: 10px;margin-bottom: unset;" data-width="50%">
|
||
<section style="text-align: justify;margin-bottom: unset;">
|
||
<p>
|
||
<strong><span leaf="">ZhangHong </span></strong>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="justify-content: flex-start;display: flex;flex-flow: row;margin-bottom: unset;">
|
||
<section style="display: inline-block;width: 100%;vertical-align: top;align-self: flex-start;flex: 0 0 auto;background-color: rgb(248, 243, 237);padding: 22px;margin-bottom: unset;" data-width="100%">
|
||
<section style="text-align: justify;margin-bottom: unset;">
|
||
<p>
|
||
<span leaf=""></span>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="margin-bottom:unset;">
|
||
<section style="-webkit-tap-highlight-color:transparent;margin-bottom:unset;">
|
||
<section style="font-size:15px;margin-bottom:unset;">
|
||
<section style="text-align:center;margin-top:10px;margin-bottom:10px;line-height:0;">
|
||
<section style="vertical-align:middle;display:inline-block;line-height:0;margin-bottom:unset;">
|
||
<section style="font-size:12px;line-height:1.6;letter-spacing:0px;color:#000000;margin-bottom:unset;">
|
||
<section style="color:#1e1e1e;font-size:16px;margin-bottom:unset;">
|
||
<section style="font-size:12px;line-height:1.6;letter-spacing:0px;color:#000000;margin-bottom:unset;">
|
||
<section style="color:#1e1e1e;font-size:16px;margin-bottom:unset;">
|
||
<section style="margin-bottom:unset;">
|
||
<section style="margin-bottom:unset;">
|
||
<section style="margin-bottom:unset;">
|
||
<section style="margin-right:auto;margin-left:auto;width:95%;margin-bottom:unset;" data-width="95%">
|
||
<section style="margin-top: 20px;margin-bottom: 20px;background-color: rgb(254, 254, 254);padding-right: 13px;padding-left: 13px;border-width: 3px;border-style: groove;border-color: rgb(239, 207, 207);">
|
||
<section style="margin-bottom:unset;">
|
||
<section style="margin-top:10px;margin-bottom:22px;text-align:left;">
|
||
<section style="display:inline-block;background-color:#fdfdfd;margin-bottom:unset;">
|
||
<section style="color:#f6d8d7;font-size:20px;letter-spacing:2px;margin-bottom:unset;">
|
||
<p>
|
||
<span leaf=""><br/></span>
|
||
</p>
|
||
</section>
|
||
<section style="margin-top:-30px;display:flex;justify-content:center;align-items:center;margin-bottom:unset;">
|
||
<section style="width: 8px;height: 8px;background-color: rgb(207, 18, 16);border-radius: 50%;margin-bottom: unset;overflow: hidden;">
|
||
<span leaf=""><br/></span>
|
||
</section>
|
||
<section style="color:#cf1210;letter-spacing:2px;margin-right:7px;margin-left:7px;margin-bottom:unset;">
|
||
<p>
|
||
<span style="color:#ab1942;"><strong><span leaf="">期刊详情</span></strong></span>
|
||
</p>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="width:100%;height:1px;background-color:#cf1210;margin-top:-25px;margin-bottom:unset;overflow:hidden;" data-width="100%">
|
||
<span leaf=""><br/></span>
|
||
</section>
|
||
</section>
|
||
</section>
|
||
<section style="margin-bottom:unset;">
|
||
<section style="margin-bottom: unset;padding-top: 15px;">
|
||
<section style="margin-bottom:unset;">
|
||
<p style="text-align:justify;">
|
||
<em><span style="font-family:微软雅黑, "Microsoft YaHei";"><span style="color:#3e3e3e;"><span leaf="">Integr Med Discov.</span></span></span></em>
|
||
<span style="font-family:微软雅黑, "Microsoft YaHei";">
|
||
<span style="color:#3e3e3e;">
|
||
<span leaf="">
|
||
</span>
|
||
<span style="letter-spacing:0px;color:#333333;line-height:28px;">
|
||
<span leaf="">。为了进一步扩大期刊的影响力并提升对学者的服务，</span>
|
||
<strong>
|
||
<span leaf="">2025年免除版面费</span>
|
||
</strong>
|
||
<span leaf="">。此外</span>
|
||
</span>
|
||
</span>
|
||
<span style="color:#333333;letter-spacing:0px;">
|
||
<span leaf="">，为进一步促进期刊发展，</span>
|
||
</span>
|
||
<strong style="color:#333333;letter-spacing:0px;">
|
||
<span leaf="">青年编委正在招募中</span>
|
||
</strong>
|
||
<span style="color:#333333;letter-spacing:0px;">
|
||
<span leaf="">，欢迎各位老师通过邮件或微信与编辑部联系沟通，期待您的加入</span>
|
||
</span>
|
||
<span style="color:#333333;letter-spacing:0px;">
|
||
<span leaf="">！</span>
|
||
</span>
|
||
</span>
|
||
</p>
|
||
<p>
|
||
<span leaf=""><br/></span>
|
||
</p>
|
||
<p style="text-align:left;">
|
||
<strong><span style="letter-spacing:0px;color:#333333;line-height:28px;"><span leaf="">期刊涵盖主题包括但不限于：</span></span></strong>
|
||
</p>
|
||
<ul style="color:#000000;font-family:微软雅黑;font-size:14px;" class=" list-paddingleft-2">
|
||
<li>
|
||
<p style="text-align: left;">
|
||
<span style="font-size:15px;"><span leaf="">20240117/06b52af8cfa499eff00a71bfdb5dc835.png</span></span>
|
||
</p>
|
||
</li>
|
||
</ul>
|
||
</section>
|
||
<section style="margin-bottom:unset;">
|
||
<section style="margin-bottom:unset;">
|
||
<section style="margin-top:15px;margin-bottom:15px;">
|
||
<section style="width:96%;margin-left:auto;margin-right:auto;margin-bottom:unset;" data-width="96%">
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