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精准医疗基因、方剂

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wuchunlei
2025-06-04 17:09:45 +08:00
parent 8dfd150e2c
commit 6852c64984
10 changed files with 426 additions and 0 deletions
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9
src/main/java/com/peanut/modules/common/dao/PrecisionMedicineGeneDao.java Normal file
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package com.peanut.modules.common.dao;
import com.github.yulichang.base.MPJBaseMapper;
import com.peanut.modules.common.entity.PrecisionMedicineGene;
import org.apache.ibatis.annotations.Mapper;
@Mapper
public interface PrecisionMedicineGeneDao extends MPJBaseMapper<PrecisionMedicineGene> {
}

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src/main/java/com/peanut/modules/common/dao/PrecisionMedicinePrescriptionDao.java Normal file
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package com.peanut.modules.common.dao;
import com.github.yulichang.base.MPJBaseMapper;
import com.peanut.modules.common.entity.PrecisionMedicinePrescription;
import org.apache.ibatis.annotations.Mapper;
@Mapper
public interface PrecisionMedicinePrescriptionDao extends MPJBaseMapper<PrecisionMedicinePrescription> {
}

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src/main/java/com/peanut/modules/common/entity/PrecisionMedicineGene.java Normal file
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package com.peanut.modules.common.entity;
import com.baomidou.mybatisplus.annotation.TableField;
import com.baomidou.mybatisplus.annotation.TableId;
import com.baomidou.mybatisplus.annotation.TableLogic;
import com.baomidou.mybatisplus.annotation.TableName;
import lombok.Data;
import java.util.Date;
@Data
@TableName("precision_medicine_gene")
public class PrecisionMedicineGene {
private static final long serialVersionUID = 1L;
@TableId
private Integer id;
//基因名称
private String name;
//基因中文名
private String namecn;
//别名
private String alias;
//描述
private String description;
//关联药材名
private String tcmName;
private Date createTime;
@TableLogic
private Integer delFlag;
}

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src/main/java/com/peanut/modules/common/entity/PrecisionMedicinePrescription.java Normal file
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package com.peanut.modules.common.entity;
import com.baomidou.mybatisplus.annotation.TableId;
import com.baomidou.mybatisplus.annotation.TableLogic;
import com.baomidou.mybatisplus.annotation.TableName;
import lombok.Data;
import java.util.Date;
@Data
@TableName("precision_medicine_prescription")
public class PrecisionMedicinePrescription {
private static final long serialVersionUID = 1L;
@TableId
private Integer id;
//方剂名称
private String name;
//别名
private String alias;
//药物组成
private String compose;
//功效
private String effect;
//主治
private String indications;
//来源
private String source;
private Date createTime;
@TableLogic
private Integer delFlag;
}

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src/main/java/com/peanut/modules/common/service/PrecisionMedicineGeneService.java Normal file
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package com.peanut.modules.common.service;
import com.baomidou.mybatisplus.extension.service.IService;
import com.peanut.modules.common.entity.PrecisionMedicineGene;
import java.util.Map;
public interface PrecisionMedicineGeneService extends IService<PrecisionMedicineGene> {
Map<String,Object> getGeneInfo(String geneIds);
}

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src/main/java/com/peanut/modules/common/service/PrecisionMedicinePrescriptionService.java Normal file
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package com.peanut.modules.common.service;
import com.baomidou.mybatisplus.extension.service.IService;
import com.peanut.modules.common.entity.PrecisionMedicinePrescription;
public interface PrecisionMedicinePrescriptionService extends IService<PrecisionMedicinePrescription> {
}

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src/main/java/com/peanut/modules/common/service/impl/PrecisionMedicineGeneServiceImpl.java Normal file
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package com.peanut.modules.common.service.impl;
import com.baomidou.mybatisplus.core.conditions.query.LambdaQueryWrapper;
import com.baomidou.mybatisplus.extension.service.impl.ServiceImpl;
import com.peanut.modules.common.dao.PrecisionMedicineGeneDao;
import com.peanut.modules.common.dao.PrecisionMedicinePrescriptionDao;
import com.peanut.modules.common.entity.PrecisionMedicineGene;
import com.peanut.modules.common.entity.PrecisionMedicinePrescription;
import com.peanut.modules.common.service.PrecisionMedicineGeneService;
import lombok.extern.slf4j.Slf4j;
import org.apache.commons.lang.StringUtils;
import org.springframework.beans.factory.annotation.Autowired;
import org.springframework.stereotype.Service;
import java.util.*;
import java.util.stream.Collectors;
@Slf4j
@Service("commonPrecisionMedicineGeneService")
public class PrecisionMedicineGeneServiceImpl extends ServiceImpl<PrecisionMedicineGeneDao, PrecisionMedicineGene> implements PrecisionMedicineGeneService {
@Autowired
private PrecisionMedicinePrescriptionDao prescriptionDao;
@Override
public Map<String,Object> getGeneInfo(String geneIds) {
Map<String,Object> res = new HashMap<>();
String[] ids = geneIds.split(",");
Set<String> tcmNames = new HashSet<>();
//查出基因匹配的所有中药
List<PrecisionMedicineGene> geneList = new ArrayList<>();
for (String id : ids) {
PrecisionMedicineGene gene = this.getById(id);
geneList.add(gene);
if (StringUtils.isNotEmpty(gene.getTcmName())){
String[] names = gene.getTcmName().split("，");
for (String str:names){
tcmNames.add(str);
}
}
}
res.put("geneList",geneList);
Map<String, Map<String,Object>> countPrescriptions = new HashMap<>();
for (String tcmName : tcmNames){
//方剂列表
List<PrecisionMedicinePrescription> prescriptions = prescriptionDao.selectList(new LambdaQueryWrapper<PrecisionMedicinePrescription>()
.like(PrecisionMedicinePrescription::getCompose,tcmName));
for (PrecisionMedicinePrescription prescription:prescriptions){
if (countPrescriptions.containsKey(prescription.getId()+"")){
Map<String,Object> map = countPrescriptions.get(prescription.getId()+"");
map.put("num",Integer.parseInt(map.get("num")+"")+1);
map.put("tcmName",map.get("tcmName")+","+tcmName);
}else {
Map<String,Object> map = new HashMap<>();
map.put("num",1);
map.put("tcmName",tcmName);
map.put("name",prescription.getName());
map.put("compose",prescription.getCompose());
map.put("total",prescription.getCompose().split("，").length);
map.put("source",prescription.getSource());
countPrescriptions.put(prescription.getId()+"",map);
}
}
}
//计算占比，并加入排序集合
List<Map<String,Object>> list = new ArrayList<>();
for (Map<String, Object> m : countPrescriptions.values()){
m.put("percent",Double.parseDouble(m.get("num").toString())/Double.parseDouble(m.get("total").toString()));
list.add(m);
}
//排序
list = list.stream().sorted((map1,map2)->{
int x = Integer.compare(Integer.parseInt(map2.get("num").toString()),Integer.parseInt(map1.get("num").toString()));
if (x!=0){
return x;
}else {
return Double.compare(Double.parseDouble(map2.get("percent").toString()),Double.parseDouble(map1.get("percent").toString()));
}
}).collect(Collectors.toList());
//将匹配最高的加入结果集合
List<Map<String,Object>> prescriptionList = new ArrayList<>();
for (Map<String,Object> map:list){
if (prescriptionList.size() > 0){
if (Integer.parseInt(prescriptionList.get(0).get("num").toString())==Integer.parseInt(map.get("num").toString())){
if (prescriptionList.size()<3){
prescriptionList.add(map);
}
}
}else {
prescriptionList.add(map);
}
}
res.put("prescriptionList",prescriptionList);
return res;
}
}

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src/main/java/com/peanut/modules/common/service/impl/PrecisionMedicinePrescriptionServiceImpl.java Normal file
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package com.peanut.modules.common.service.impl;
import com.baomidou.mybatisplus.extension.service.impl.ServiceImpl;
import com.peanut.modules.common.dao.PrecisionMedicinePrescriptionDao;
import com.peanut.modules.common.entity.PrecisionMedicinePrescription;
import com.peanut.modules.common.service.PrecisionMedicinePrescriptionService;
import lombok.extern.slf4j.Slf4j;
import org.springframework.stereotype.Service;
@Slf4j
@Service("commonPrecisionMedicinePrescriptionService")
public class PrecisionMedicinePrescriptionServiceImpl extends ServiceImpl<PrecisionMedicinePrescriptionDao, PrecisionMedicinePrescription> implements PrecisionMedicinePrescriptionService {
}

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src/main/java/com/peanut/modules/master/controller/PrecisionMedicineController.java Normal file
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package com.peanut.modules.master.controller;
import com.baomidou.mybatisplus.core.conditions.query.LambdaQueryWrapper;
import com.baomidou.mybatisplus.extension.plugins.pagination.Page;
import com.peanut.common.utils.R;
import com.peanut.modules.common.entity.PrecisionMedicineGene;
import com.peanut.modules.common.entity.PrecisionMedicinePrescription;
import com.peanut.modules.common.service.PrecisionMedicineGeneService;
import com.peanut.modules.common.service.PrecisionMedicinePrescriptionService;
import lombok.extern.slf4j.Slf4j;
import org.apache.commons.lang.StringUtils;
import org.springframework.beans.factory.annotation.Autowired;
import org.springframework.web.bind.annotation.RequestBody;
import org.springframework.web.bind.annotation.RequestMapping;
import org.springframework.web.bind.annotation.RestController;
import java.util.Map;
//精准医疗基因、方剂
@Slf4j
@RestController("masterPrecisionMedicine")
@RequestMapping("master/precisionMedicine")
public class PrecisionMedicineController {
@Autowired
private PrecisionMedicineGeneService geneService;
@Autowired
private PrecisionMedicinePrescriptionService prescriptionService;
//基因管理
@RequestMapping("/getGeneListByPage")
public R getGeneListByPage(@RequestBody Map<String,Object> params) {
LambdaQueryWrapper<PrecisionMedicineGene> wrapper = new LambdaQueryWrapper();
if (StringUtils.isNotEmpty(params.get("name").toString())) {
wrapper.like(PrecisionMedicineGene::getName,params.get("name"));
}
wrapper.orderByDesc(PrecisionMedicineGene::getCreateTime);
Page<PrecisionMedicineGene> page = geneService.page(new Page<>(
Long.parseLong(params.get("current").toString()), Long.parseLong(params.get("limit").toString())), wrapper);
return R.ok().put("result", page);
}
@RequestMapping("/getGeneById")
public R getGeneById(@RequestBody Map<String,Object> params) {
return R.ok().put("result", geneService.getById(params.get("id").toString()));
}
@RequestMapping("/saveGene")
public R saveMessage(@RequestBody PrecisionMedicineGene gene) {
geneService.save(gene);
return R.ok();
}
@RequestMapping("/updateGene")
public R updateGene(@RequestBody PrecisionMedicineGene gene) {
geneService.updateById(gene);
return R.ok();
}
@RequestMapping("/delGene")
public R delGene(@RequestBody Map<String,Object> params) {
geneService.removeById(params.get("id").toString());
return R.ok();
}
//方剂管理
@RequestMapping("/getPrescriptionListByPage")
public R getPrescriptionListByPage(@RequestBody Map<String,Object> params) {
LambdaQueryWrapper<PrecisionMedicinePrescription> wrapper = new LambdaQueryWrapper();
if (StringUtils.isNotEmpty(params.get("name").toString())) {
wrapper.like(PrecisionMedicinePrescription::getName,params.get("name"));
}
wrapper.orderByDesc(PrecisionMedicinePrescription::getCreateTime);
Page<PrecisionMedicinePrescription> page = prescriptionService.page(new Page<>(
Long.parseLong(params.get("current").toString()), Long.parseLong(params.get("limit").toString())), wrapper);
return R.ok().put("result", page);
}
@RequestMapping("/getPrescriptionById")
public R getPrescriptionById(@RequestBody Map<String,Object> params) {
return R.ok().put("result", prescriptionService.getById(params.get("id").toString()));
}
@RequestMapping("/savePrescription")
public R savePrescription(@RequestBody PrecisionMedicinePrescription prescription) {
prescriptionService.save(prescription);
return R.ok();
}
@RequestMapping("/updatePrescription")
public R updatePrescription(@RequestBody PrecisionMedicinePrescription prescription) {
prescriptionService.updateById(prescription);
return R.ok();
}
@RequestMapping("/delPrescription")
public R delPrescription(@RequestBody Map<String,Object> params) {
prescriptionService.removeById(params.get("id").toString());
return R.ok();
}
}

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src/main/java/com/peanut/modules/taihumed/controller/PrecisionMedicineController.java Normal file
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package com.peanut.modules.taihumed.controller;
import com.baomidou.mybatisplus.core.conditions.query.LambdaQueryWrapper;
import com.peanut.common.utils.R;
import com.peanut.modules.common.entity.PrecisionMedicineGene;
import com.peanut.modules.common.service.PrecisionMedicineGeneService;
import com.peanut.modules.common.service.PrecisionMedicinePrescriptionService;
import lombok.extern.slf4j.Slf4j;
import org.apache.poi.ss.usermodel.Row;
import org.apache.poi.ss.usermodel.Sheet;
import org.apache.poi.xssf.usermodel.XSSFWorkbook;
import org.springframework.beans.factory.annotation.Autowired;
import org.springframework.web.bind.annotation.RequestBody;
import org.springframework.web.bind.annotation.RequestMapping;
import org.springframework.web.bind.annotation.RestController;
import javax.servlet.http.HttpServletResponse;
import java.io.IOException;
import java.io.OutputStream;
import java.net.URLEncoder;
import java.util.*;
@Slf4j
@RestController("taihumedPrecisionMedicine")
@RequestMapping("taihumed/precisionMedicine")
public class PrecisionMedicineController {
@Autowired
private PrecisionMedicineGeneService geneService;
@Autowired
private PrecisionMedicinePrescriptionService prescriptionService;
@RequestMapping("/getPrecisionMedicineGenes")
public R getPrecisionMedicineGenes(@RequestBody Map<String,Object> params){
List<PrecisionMedicineGene> genes = geneService.list(new LambdaQueryWrapper<PrecisionMedicineGene>()
.and(t->t.like(PrecisionMedicineGene::getName,params.get("name"))
.or().like(PrecisionMedicineGene::getAlias,params.get("name"))));
return R.ok().put("genes",genes);
}
@RequestMapping("/getGenes")
public void getPrescriptions(HttpServletResponse response){
List<PrecisionMedicineGene> genes = geneService.list();
XSSFWorkbook wb = new XSSFWorkbook();
//创建一张表
Sheet sheet = wb.createSheet("Student");
//创建第一行，起始为0
Row titleRow = sheet.createRow(0);
titleRow.createCell(0).setCellValue("基因名称");
titleRow.createCell(1).setCellValue("基因中文名");
titleRow.createCell(2).setCellValue("描述");
titleRow.createCell(3).setCellValue("关联药材名");
titleRow.createCell(4).setCellValue("关联方剂");
//序号，默认为1
int cell = 1;
//遍历
for (PrecisionMedicineGene gene:genes){
Map<String,Object> geneInfo = geneService.getGeneInfo(gene.getId().toString());
List<Map<String,Object>> prescriptionList = (List<Map<String, Object>>) geneInfo.get("prescriptionList");
String prescriptionStr = "";
for (Map<String, Object> prescription:prescriptionList) {
prescriptionStr+="匹配方剂："+prescription.get("name")+",方剂组成："+prescription.get("compose")+"出处："+prescription.get("source")+";";
}
Row row = sheet.createRow(cell);
row.createCell(0).setCellValue(gene.getName());
row.createCell(1).setCellValue(gene.getNamecn());
row.createCell(2).setCellValue(gene.getDescription());
row.createCell(3).setCellValue(gene.getTcmName());
row.createCell(4).setCellValue(prescriptionStr);
//序号自增
cell++;
}
String fileName = "基因药材方剂.xlsx";
OutputStream outputStream =null;
try {
//文件名编码格式
fileName = URLEncoder.encode(fileName,"UTF-8");
//设置ContentType请求信息格式
response.setContentType("application/vnd.ms-excel");
//设置标头
response.setHeader("Content-disposition", "attachment;filename=" + fileName);
outputStream = response.getOutputStream();
wb.write(outputStream);
} catch (IOException e) {
e.printStackTrace();
}finally {
try {
outputStream.flush();
outputStream.close();
} catch (IOException e) {
e.printStackTrace();
}
}
// return R.ok().put("genes",genes);
}
}