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2. The struc-tural di-ver-sity of nat-u-
ral flavonoids
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\TU/Calibri(0)/m/n/8 and re-lieve cough. Sim-i-larly, other an-cient Chi-nese te
xts, such as
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\TU/Calibri(0)/m/n/8 “\TU/Calibri(0)/m/it/8 Newly Re-vised Ma-te-ria Med-ica\
TU/Calibri(0)/m/n/8 ” (Jing Zhang et al. wrote in Tang
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\TU/Calibri(0)/m/it/8 far-fara\TU/Calibri(0)/m/n/8 L. can com-bat COPD through
var-i-ous mech-a-nisms, such as
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[]\TU/lmr/m/n/8 The main patho-log-i-cal fea-tures of COPD in-clude air-way
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\TU/lmr/m/n/8 air-flow lim-i-ta-tion, mu-cus over-pro-duc-tion, chronic bron-chi
-tis,
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\TU/lmr/m/n/8 em-phy-sema, or dam-age to the alve-o-lar sep-tal walls. These
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\TU/lmr/m/n/8 flavones, flavonoid gly-co-sides, Isoflavones, cat-e-chins (fla-va
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\TU/lmr/m/n/8 like-wise been proved to in-hibit the de-vel-op-ment of COPD by
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\TU/lmr/m/n/8 mod-u-late NF-κB sig-nalling in COPD, ac-knowl-edg-ing NF-
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Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no ĸ (U+0138) in font [lmroman8-regular]:+tlig;!
Missing character: There is no ĸ (U+0138) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
[4
Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;!
Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-bold]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-italic]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-italic]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
] [5<./image/image-60721.png>]
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Underfull \vbox (badness 1342) has occurred while \output is active []
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Underfull \hbox (badness 2035) in paragraph at lines 146--146
\TU/lmr/m/n/8 lo-cal-i-sa-tions and func-tions, is the first sir-tuin that reg-u
-lates
[]
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;!
Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Underfull \vbox (badness 4543) has occurred while \output is active []
[6
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no ĸ (U+0138) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
<./image/file_67aee377039e2.jpg>]
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Underfull \hbox (badness 1616) in paragraph at lines 151--151
\TU/lmr/m/n/8 al-le-vi-ate the patho-log-i-cal in-flam-ma-tion as-so-ci-ated wit
h COPD
[]
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
[7
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
<./image/file_68999e3c72e62.png>]
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Underfull \hbox (badness 2591) in paragraph at lines 153--153
[]\TU/lmr/m/n/8 Flavonoids in-hibit the ac-ti-va-tion of the EGFR sig-nalling
[]
Underfull \hbox (badness 2245) in paragraph at lines 153--153
\TU/lmr/m/n/8 ex-pres-sion and de-creas-ing mucin ex-pres-sion and in-flam-ma-ti
on
[]
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;!
Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;!
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\TU/lmr/m/n/8 flavonoids for the treat-ment of chronic ob-struc-tive pul-monary
[]
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[]\TU/CharisSIL(1)/m/n/8 World Health Or-ga-ni-za-tion. Global health es-ti-mate
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\TU/CharisSIL(1)/m/n/8 https://www.who.int/data/gho/. Pub-lished 2019. Ac-cessed
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\TU/CharisSIL(1)/m/n/8 of dis-ease from 2002 to 2030. \TU/CharisSIL(0)/m/it/8 PL
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[]
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[]\TU/CharisSIL(1)/m/n/8 MacLeod M, Papi A, Con-toli M, et al. Chronic ob-struc-
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[]
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\TU/CharisSIL(1)/m/n/8 pul-monary dis-ease ex-ac-er-ba-tion fun-da-men-tals: Di-
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[]
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[]
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[]
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[]\TU/CharisSIL(1)/m/n/8 Sam-suz-za-man Md, Ud-din MdS, Shah MA, et al. Nat-u-ra
l
[]
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[]
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[]
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[]\TU/CharisSIL(1)/m/n/8 Tag-gart C, Cervantes-Laurean D, Kim G, et al. Ox-i-da-
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[]
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[]
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[]
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[]\TU/CharisSIL(1)/m/n/8 Brus-selle GG, Joos GF, Bracke KR. New in-sights into
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[]
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[]\TU/CharisSIL(1)/m/n/8 Majo J, Ghezzo H, Co-sio MG. Lym-pho-cyte pop-u-la-tion
and
[]
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[]\TU/CharisSIL(1)/m/n/8 La-gente V, Manoury B, Né-nan S, et al. Role of ma-tri
x
[]
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[]\TU/CharisSIL(1)/m/n/8 Shao MXG, Nakanaga T, Nadel JA. Cigarette smoke
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[]
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[]\TU/CharisSIL(1)/m/n/8 Sel-man M, Car-rillo G, Estrada A, et al. Ac-cel-er-ate
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[]
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[]
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[]\TU/CharisSIL(1)/m/n/8 Birru RL, Bein K, Bon-darchuk N, et al. An-timi-cro-bia
l and
[]
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\TU/CharisSIL(1)/m/n/8 Res-pi-ra-tory Pathogens As-so-ci-ated With Chronic Ob-st
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\TU/CharisSIL(1)/m/n/8 Stress via the Reg-u-la-tion of the Nrf2 and NF-κB
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\TU/CharisSIL(1)/m/n/8 Yel-low A on In-flam-ma-tory In-jury in Chronic Ob-struc-
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\TU/CharisSIL(1)/m/n/8 SIRT1-NAD+-CD38 Axis. \TU/CharisSIL(0)/m/it/8 Am J Chin
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[]
Underfull \hbox (badness 1383) in paragraph at lines 209--209
[]\TU/CharisSIL(1)/m/n/8 Li J, Tong D, Liu J, et al. Orox-ylin A at-ten-u-ates
cigarette
[]
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\TU/CharisSIL(1)/m/n/8 smoke-induced lung in-flam-ma-tion by ac-ti-vat-ing Nrf2.
\TU/CharisSIL(0)/m/it/8 Int
[]
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[]\TU/CharisSIL(1)/m/n/8 Mi-tani A, Azam A, Vup-pusetty C, et al. Quercetin re-s
tores
[]
Underfull \hbox (badness 1552) in paragraph at lines 209--209
\TU/CharisSIL(1)/m/n/8 cor-ti-cos-teroid sen-si-tiv-ity in cells from pa-tients with chronic
[]
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[]\TU/CharisSIL(1)/m/n/8 Farazud-din M, Mishra R, Jing Y, et al. Quercetin pre-v
ents
[]
Underfull \hbox (badness 1990) in paragraph at lines 209--209
[]\TU/CharisSIL(1)/m/n/8 Wei P, Chen ZB, Wang CE, et al. Pro-tec-tive func-tion and
[]
[11
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[]\TU/CharisSIL(1)/m/n/8 Mc-Cluskey ES, Liu N, Pandey A, et al. Quercetin im-pro
ves
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\TU/CharisSIL(1)/m/n/8 fisetin al-le-vi-ates cigarette smoke‐in-duced ox-ida-t
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\TU/CharisSIL(1)/m/n/8 from Vi-tex Fruc-tus, ame-lio-rates the cigarette smoke-i
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\TU/CharisSIL(1)/m/n/8 acute lung in-flam-ma-tory re-sponse in a murine model.
\TU/CharisSIL(0)/m/it/8 Int
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[]\TU/CharisSIL(1)/m/n/8 Lu LJ, Tian H, Zheng Y, et al. Ef-fects of cas-ticin on
[]
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\TU/CharisSIL(1)/m/n/8 in-hi-bi-tion of the NOX4‐me-di-ated NF‐κB sig-n
al-ing path-way.
[]
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\TU/CharisSIL(1)/m/n/8 Smoke via Mod-u-la-tion of the TRPV1 and CYP2A13/NRF2
[]
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[]\TU/CharisSIL(1)/m/n/8 Chen Z, Wu H, Fan W, et al. Narin-genin sup-presses
[]
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\TU/CharisSIL(1)/m/n/8 com-pounds of aged cit-rus peel (chenpi) pre-vent-ing chr
onic
[]
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\TU/CharisSIL(1)/m/n/8 smoke in-duced fer-rop-to-sis in the patho-gen-e-sis of
chronic
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\TU/CharisSIL(1)/m/n/8 ob-struc-tive pul-monary dis-ease by ac-ti-vat-ing Nrf2-m
ediated
[]
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[]\TU/CharisSIL(1)/m/n/8 Liu X, Ma Y, Luo L, et al. Tax-i-folin ame-lio-rates ci
garette
[]
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\TU/CharisSIL(1)/m/n/8 smoke-induced chronic ob-struc-tive pul-monary dis-ease
via
[]
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\TU/CharisSIL(1)/m/n/8 in-hibit-ing in-flam-ma-tion and apop-to-sis. \TU/Charis
SIL(0)/m/it/8 Int Im-munophar-ma-col\TU/CharisSIL(1)/m/n/8 .
[]
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\TU/CharisSIL(1)/m/n/8 by in-hibit-ing NF-κB ac-ti-va-tion in cigarette smo
ke in-duced
[]
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\TU/CharisSIL(1)/m/n/8 in-flam-ma-tory mod-els. \TU/CharisSIL(0)/m/it/8 Pulm Pha
r-ma-col Ther\TU/CharisSIL(1)/m/n/8 . 2010;23(5):411.
[]
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[]\TU/CharisSIL(1)/m/n/8 Li L, Bao H, Wu J, et al. Baicalin is anti-inflammatory
in
[]
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[]\TU/CharisSIL(1)/m/n/8 Wang G, Mo-ham-mad-tur-sun N, Lv Y, et al. Baicalin Ex-
erts
[]
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\TU/CharisSIL(1)/m/n/8 smoke-induced air-way in-flam-ma-tion in rats by mod-u-la
t-ing
[]
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\TU/CharisSIL(1)/m/n/8 HDAC2/NF-κB/PAI-1 sig-nalling. \TU/CharisSIL(0)/m/i
t/8 Pulm Phar-ma-col Ther\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Xiao XF, Zhao SL, Wang W, et al. Baicalin up-reg-u-late
s
[]
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\TU/CharisSIL(1)/m/n/8 miR-4451ef-fect on lipopolysaccharide-induced apop-to-sis
and
[]
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\TU/CharisSIL(1)/m/n/8 in-flam-ma-tory re-sponse in HBE16 cells. \TU/CharisSIL(
0)/m/it/8 Lishizhen Med Res\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Ju J, Li Z, Shi Q. Baicalin In-hibits In-flam-ma-tion
in Rats
[]
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\TU/CharisSIL(1)/m/n/8 with Chronic Ob-struc-tive Pul-monary Dis-ease by the
[]
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\TU/CharisSIL(1)/m/n/8 TLR2/MYD88/NF-κBp65 Sig-nal-ing Path-way. \TU/Chari
sSIL(0)/m/it/8 Evid Based
[]
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\TU/CharisSIL(1)/m/n/8 in COPD by In-hibit-ing miR-125a. \TU/CharisSIL(0)/m/it/
8 Appl Biochem Biotech-nol\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Kim YH, Kang MK, Lee EJ, et al. As-tra-galin In-hibits
[]
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\TU/CharisSIL(1)/m/n/8 In-flam-ma-tion and Dis-rupts PAR Ac-ti-va-tion and Ox-id
a-tive
[]
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[]\TU/CharisSIL(1)/m/n/8 Lu R, Xu K, Qin Y, et al. Net-work Phar-ma-col-ogy and
[]
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\TU/CharisSIL(1)/m/n/8 Icariin Com-bined with No-biletin against Chronic Ob-stru
c-tive
[]
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\TU/CharisSIL(1)/m/n/8 Pul-monary Dis-eases. \TU/CharisSIL(0)/m/it/8 Evid Based Com-ple-ment Al-ter-nat Med\TU/CharisSIL(1)/m/n/8 .
[]
[12
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[]\TU/CharisSIL(1)/m/n/8 Kim SH, Hong JH, Yang WK, et al. Herbal Com-bi-na-tiona
l
[]
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\TU/CharisSIL(1)/m/n/8 Gly-cyrrhizic Acid, Tilianin In-hibits Neu-trophilic Lung
[]
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[]\TU/CharisSIL(1)/m/n/8 Wang L, Jiang W, Wang J, et al. Puer-arin in-hibits
[]
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\TU/CharisSIL(1)/m/n/8 FUNDC1-mediated mi-to-chon-drial au-tophagy and CSE-induc
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[]
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\TU/CharisSIL(1)/m/n/8 apop-to-sis of hu-man bronchial ep-ithe-lial cells by ac-
ti-vat-ing
[]
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\TU/CharisSIL(1)/m/n/8 the PI3K/AKT/mTOR sig-nal-ing path-way. \TU/CharisSIL(0)
/m/it/8 Ag-ing (Al-bany NY)\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Li XM, Jiang XH, Zeng RH, et al. For-mononetin at-ten-u
-ates
[]
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\TU/CharisSIL(1)/m/n/8 cigarette smoke-induced COPD in mice by sup-press-ing
[]
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\TU/CharisSIL(1)/m/n/8 in-flam-ma-tion, en-do-plas-mic retic-u-lum stress, and
apop-to-sis
[]
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\TU/CharisSIL(1)/m/n/8 smoke-induced lung in-flam-ma-tion via in-hibit-ing ROS/N
LRP3
[]
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\TU/CharisSIL(1)/m/n/8 In-flam-ma-tion and Mu-cus Se-cre-tion In-duced by Cigare
tte
[]
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\TU/CharisSIL(1)/m/n/8 Smoke via Sup-pres-sion of ERK‐SP1 Path-way. \TU/Chari
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[]
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[]\TU/CharisSIL(1)/m/n/8 Ko JW, Shin NR, Park SH, et al. Sili-b-inin in-hibits
the
[]
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[]\TU/CharisSIL(1)/m/n/8 Li DD, Xu D, Wang T, et al. Sily-marin At-ten-u-ates Ai
r-way
[]
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[]\TU/CharisSIL(1)/m/n/8 Li D, Hu J, Wang T, et al. Sily-marin at-ten-u-ates cig
arette
[]
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[]\TU/CharisSIL(1)/m/n/8 Tao Z, Bai S, Wu G, et al. Ther-a-peu-tic ef-fect of gi
nkgetin
[]
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[]\TU/CharisSIL(1)/m/n/8 Chen XL, Geng DS. Ef-fect of To-tal Flavonoids from Nig
ella
[]
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\TU/CharisSIL(1)/m/n/8 Dis-ease Model Rats and Its Mech-a-nism. \TU/CharisSIL(0
)/m/it/8 Chin Pharm J\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Yang JM, Wang HZ, Shi QX, et al. Ef-fect and Mech-a-nis
m
[]
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\TU/CharisSIL(1)/m/n/8 of To-tal Flavonoids from Scutel-laria Baicalen-sis Georg
i in
[]
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[]\TU/CharisSIL(1)/m/n/8 Jian T, Chen J, Ding X, et al. Flavonoids iso-lated fro
m
[]
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[]\TU/CharisSIL(1)/m/n/8 Re-pine JE, Bast A, Lankhorst I. Ox-ida-tive Stress in Chronic
[]
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\TU/CharisSIL(1)/m/n/8 Ob-struc-tive Pul-monary Dis-ease. \TU/CharisSIL(0)/m/it
/8 Am J Respir Crit Care Med\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Suzuki M, Bet-suyaku T, Ito Y, et al. Down-Regulated
[]
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\TU/CharisSIL(1)/m/n/8 NF-E2–Re-lated Fac-tor 2 in Pul-monary Macrophages of
Aged
[]
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\TU/CharisSIL(1)/m/n/8 Smok-ers and Pa-tients with Chronic Ob-struc-tive Pul-mon
ary
[]
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\TU/CharisSIL(1)/m/n/8 Neu-trophil Cy-to-toxic Po-ten-tial via Se-lec-tive En-ha
nce-ment of
[]
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[13
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ript=latn;language=dflt;"!
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[]\TU/CharisSIL(1)/m/n/8 Lora JM, Zhang DM, Liao SM, et al. Tu-mor Necro-sis
[]
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\TU/CharisSIL(1)/m/n/8 Factor-α Trig-gers Mu-cus Pro-duc-tion in Air-way Ep-ith
e-lium
[]
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[]\TU/CharisSIL(1)/m/n/8 Takeuchi O, Takeda K, Hoshino K, et al. Cel-lu-lar
[]
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\TU/CharisSIL(1)/m/n/8 re-sponses to bac-te-rial cell wall com-po-nents are me-d
i-ated
[]
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\TU/CharisSIL(1)/m/n/8 through MyD88-dependent sig-nal-ing cas-cades. \TU/Chari
sSIL(0)/m/it/8 Int Im-munol\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Ra-jen-dra-sozhan S, Yang SR, Kin-nula VL, et al. SIRT1
, an
[]
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[]\TU/CharisSIL(1)/m/n/8 Wang B, Lim DJ, Han J, et al. Novel Cy-to-plas-mic Pro-
teins
[]
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\TU/CharisSIL(1)/m/n/8 of Non-ty-peable Haemophilus in-fluen-zae Up-regulate
[]
Underfull \hbox (badness 5217) in paragraph at lines 209--209
\TU/CharisSIL(1)/m/n/8 Hu-man MUC5AC Mucin Tran-scrip-tion via a Pos-i-tive p38
[]
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\TU/CharisSIL(1)/m/n/8 Mitogen-activated Pro-tein Ki-nase Path-way and a Neg-a-t
ive
[]
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\TU/CharisSIL(1)/m/n/8 Phos-pho-inosi-tide 3-Kinase-Akt Path-way. \TU/CharisSIL
(0)/m/it/8 J Biol Chem\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 An-tunes MA, Rocco PRM. Elastase-induced pul-monary
[]
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\TU/CharisSIL(1)/m/n/8 em-phy-sema: in-sights from ex-per-i-men-tal mod-els. \T
U/CharisSIL(0)/m/it/8 An Acad
[]
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[]\TU/CharisSIL(1)/m/n/8 Soltani A, Wal-ters EH, Reid D, et al. In-haled cor-ti-
cos-teroid
[]
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[]\TU/CharisSIL(1)/m/n/8 Park JW, Ry-ter SW, Choi AMK. Func-tional Sig-nif-i-can
ce of
[]
Underfull \hbox (badness 1917) in paragraph at lines 209--209
\TU/CharisSIL(1)/m/n/8 Apop-to-sis in Chronic Ob-struc-tive Pul-monary Dis-ease.
\TU/CharisSIL(0)/m/it/8 COPD\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Wang L, Mou L, Guan S, et al. Isoliquir-it-i-genin in-d
uces
[]
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\TU/CharisSIL(1)/m/n/8 neurodevelopmental-toxicity and anxiety-like be-hav-ior
in
[]
Underfull \hbox (badness 1635) in paragraph at lines 209--209
\TU/CharisSIL(1)/m/n/8 ze-brafish lar-vae. \TU/CharisSIL(0)/m/it/8 Comp Biochem Phys-iol C Tox-i-col Phar-ma-col\TU/CharisSIL(1)/m/n/8 .
[]
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\TU/CharisSIL(1)/m/n/8 in treat-ment of di-a-betic pe-riph-eral neu-ropa-thy: a sys-tem-atic
[]
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[]\TU/CharisSIL(1)/m/n/8 Wedzicha JA. Causes of Death in Smok-ers: Im-pli-ca-tio
ns for
[]
Underfull \hbox (badness 3407) in paragraph at lines 209--209
\TU/CharisSIL(1)/m/n/8 Chronic Ob-struc-tive Pul-monary Dis-ease Man-age-ment ac
ross
[]
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\TU/CharisSIL(1)/m/n/8 dis-ease in never-smokers: risk fac-tors, patho-gen-e-sis
, and
[]
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\TU/CharisSIL(1)/m/n/8 dis-ease over-lap syn-drome. \TU/CharisSIL(0)/m/it/8 Curr
Opin Im-munol\TU/CharisSIL(1)/m/n/8 . 2020;66:161.
[]
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[]\TU/CharisSIL(1)/m/n/8 Brightling C, Green-ing N. Air-way in-flam-ma-tion in
COPD:
[]
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\TU/CharisSIL(1)/m/n/8 Mod-els and Hu-man Chronic Ob-struc-tive Pul-monary Dis-e
ase
[]
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\TU/CharisSIL(1)/m/n/8 ep-ithe-lial cell au-tophagy through pla-cen-tal growth
fac-tor.
[]
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[]\TU/CharisSIL(1)/m/n/8 Zeng X, Xi Y, Jiang W. Pro-tec-tive roles of flavonoids
and
[]
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[]\TU/CharisSIL(1)/m/n/8 Hi-rayama F, Lee AH, Binns CW, et al. Di-etary in-take of
[]
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\TU/CharisSIL(1)/m/n/8 pul-monary dis-ease: Pos-si-ble pro-tec-tive ef-fect of
tra-di-tional
[]
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[]\TU/CharisSIL(1)/m/n/8 Bon-donno NP, Par-menter BH, Dal-gaard F, et al. Flavon
oid
[]
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[]\TU/CharisSIL(1)/m/n/8 Hogg JC, Timens W. The Pathol-ogy of Chronic Ob-struc-t
ive
[]
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\TU/CharisSIL(1)/m/n/8 Pul-monary Dis-ease. \TU/CharisSIL(0)/m/it/8 Annu Rev Pat
hol Mech Dis\TU/CharisSIL(1)/m/n/8 . 2009;4:435.
[]
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[]\TU/CharisSIL(1)/m/n/8 David B, Bafad-hel M, Koen-der-man L, et al. Eosinophil
ic
[]
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\TU/CharisSIL(1)/m/n/8 in-flam-ma-tion in COPD: from an in-flam-ma-tory marker
to a
[]
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[]\TU/CharisSIL(1)/m/n/8 Feng YY, Li M, Yangzhong XT, et al. Py-rop-to-sis in
[]
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\TU/CharisSIL(1)/m/n/8 inflammation-related res-pi-ra-tory dis-ease. \TU/Charis
SIL(0)/m/it/8 J Phys-iol Biochem\TU/CharisSIL(1)/m/n/8 .
[]
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[]\TU/CharisSIL(1)/m/n/8 Kirkham PA, Barnes PJ. Ox-ida-tive Stress in COPD. \TU
/CharisSIL(0)/m/it/8 Chest\TU/CharisSIL(1)/m/n/8 .
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[]\TU/CharisSIL(1)/m/n/8 McGuin-ness A, Sapey E. Ox-ida-tive Stress in COPD: Sou
rces,
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[]\TU/CharisSIL(1)/m/n/8 Wang R, Ramos C, Joshi I, et al. Hu-man lung
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\TU/CharisSIL(1)/m/n/8 myofibroblast-derived in-duc-ers of alve-o-lar ep-ithe-li
al
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\TU/CharisSIL(1)/m/n/8 apop-to-sis iden-ti-fied as an-giotensin pep-tides. \TU/
CharisSIL(0)/m/it/8 Am J Phys-iol\TU/CharisSIL(1)/m/n/8 .
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\TU/CharisSIL(1)/m/n/8 cell and or-gan cul-tures of ro-dent res-pi-ra-tory ep-it
he-lium
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\TU/CharisSIL(1)/m/n/8 via an arachi-donic acid-dependent mech-a-nism. \TU/Char
isSIL(0)/m/it/8 J Clin In-vest\TU/CharisSIL(1)/m/n/8 .
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[]\TU/CharisSIL(1)/m/n/8 Abed DA, Gold-stein M, Al-banyan H, et al. Dis-cov-ery of
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[]\TU/CharisSIL(1)/m/n/8 Bor-mann T, Maus R, Stolper J, et al. Role of ma-trix
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[]\TU/CharisSIL(1)/m/n/8 Hod-gin KS, Dono-van EK, Kekes-Szabo S, et al. A
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\TU/CharisSIL(1)/m/n/8 Placebo-Controlled, Pseudo-Randomized, Crossover Trial of
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\TU/CharisSIL(1)/m/n/8 cus-p-i-da-tum), Lu-te-olin, and Fisetin (Rhus suc-cedane
a). \TU/CharisSIL(0)/m/it/8 Int J
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[]\TU/CharisSIL(1)/m/n/8 Re-bello CJ, Beyl RA, Ler-tora JJL, et al. Safety and
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\TU/CharisSIL(1)/m/n/8 phar-ma-coki-net-ics of narin-genin: A ran-dom-ized, con-
trolled,
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\TU/CharisSIL(1)/m/n/8 sin-gle‐as-cend-ing‐dose clin-i-cal trial. \TU/Chari
sSIL(0)/m/it/8 Di-a-betes Obes Metab\TU/CharisSIL(1)/m/n/8 .
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[]\TU/CharisSIL(1)/m/n/8 Mori-waki M, Kito K, Nak-a-gawa R, et al. Mu-ta-genic,
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\TU/CharisSIL(1)/m/n/8 Acute, and Sub-chronic Tox-i-c-ity Stud-ies of the
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\TU/CharisSIL(1)/m/n/8 Hesperetin-7-Glucoside–β-Cyclodextrin In-clu-sion Com-
plex.
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\TU/CharisSIL(1)/m/n/8 par-tial phar-ma-co-dy-namic and ini-tial safety anal-y-s
is of
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\TU/CharisSIL(1)/m/n/8 green tea ex-tract on weight re-duc-tion: A ran-dom-ized,
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\TU/CharisSIL(1)/m/n/8 double-blind, placebo-controlled clin-i-cal trial. \TU/C
harisSIL(0)/m/it/8 Clin Nutr\TU/CharisSIL(1)/m/n/8 .
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\TU/CharisSIL(1)/m/n/8 (Milk This-tle) on Liver Dis-ease in Pa-tients With Chron
ic
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\TU/CharisSIL(1)/m/n/8 Hep-ati-tis C Un-suc-cess-fully Treated With In-ter-feron
Ther-apy.
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