\documentclass[
journal=tmr,
journalname={{Traditional Medicine Research}},
layout=largetwo,
year=2025,%年
volume=37,%卷
no=12,%期
page=23,%号
]{tmr-tex}

\doi{10.53388/TMR20250407002}
\journalweb{https://www.tmrjournals.com/tmr}

\usepackage{amsmath}
\usepackage[nopatch]{microtype}
\usepackage{booktabs}
\usepackage[backend=biber]{biblatex}
\usepackage{xcolor}
\usepackage{tabularray}
\addbibresource{example.bib}

\title{Investigating the potential mechanisms of \textit{Wenqing Yin} against atopic dermatitis based on network pharmacology, experimental pharmacology, and molecular docking}

\author{Yi-Xuan Li}
\affiliation{School of Chinese Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, 510632, China}
\alsoaffiliation{Guangzhou Medical University Affiliated Traditional Chinese Medicine Hospital, No. 16 Zhuji Road, Liwan District, Guangzhou, 510130‌‌, China}
\firstauthor
\author{Yi Liao}
\affiliation{School of Chinese Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, 510632, China}
\author{Cheng-Hong Sun}
\affiliation{State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., No. 209 Hongqi Road, Lanshan District, Linyi, 276000, China}
\author{Di Zhang}
\email{dizhang0915@jnu.edu.cn}
\affiliation{School of Chinese Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, 510632, China}
\author{Shu-Jie Tang}
\email{tsj697@163.com}
\affiliation{School of Chinese Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, 510632, China}
\author{Guo-Dong Sun}
\email{sgd96@jnu.edu.cn}
\affiliation{Guandgong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital (Heyuan Shenhe People’s Hospital), Jinan University, Donghuan Road, Zijin, Heyuan 517000, China}
\alsoaffiliation{Department of Orthopedics, First Affiliated Hospital, Jinan University, 613 Huangpu Avenue West, Tianhe District,Guangzhou, 510632, China}
\author{Guo-Dong Sun}
\email{sgd96@jnu.edu.cn}
\firstauthor

\Correspondence{Wei Quan, Department of Pharmacy, Affiliated Hospital of Shaanxi University of Chinese Medicine, No. 6, Weiyang West Road, Xianyang712000, China. E-mail: fmmuquanwei@163.com. Ya-Jun Shi, School of Pharmacy, Shaanxi University of Chinese Medicine, No. 1, Middle Section of CenturyAvenue, Xi’an 712046, China..}


\keywords{keyword entry 1, keyword entry 2, keyword entry 3} %

\authorcontributions{Han SY was responsible for formal analysis, investigation, and methodology. Wang JH was responsible for conceptualization, supervision, and writing the original draft. All authors have read and agreed to the published version of the manuscript.}
\competinginterests{The authors declare no conflicts of interest.}
\Acknowledgments{We gratefully acknowledge Prof. Hojun Kim of the College of Korean Medicine, Dongguk University, for his institutional support and encouragement throughout the preparation of this Perspective. This study was supported by the National Research Foundation of Korea (2020R1F1A1074155).}
\Peerreviewinformation{Traditional Medicine Research thanks all anonymous reviewers for their contribution to the peer review of this paper}
\Abbreviations{AAA, aromatic amino acids; ALD, alcoholic liver disease; BCAA, branched-chain amino acids; CHOL, cholesterol; HF, herbal formula; HYP, hyperlipidemia; KM mice, Kunming mice; NOD, non-obese diabetic; SCFAs, short-chain fatty acids; SD rat, Sprague-Dawley rat; T1D, type 1 diabetes; T2D, type 2 diabetes; Treg, regulatory T cells.}
\Citation{Han SY, Wang JH. Therapeutic potential of Prevotella spp. in metabolic disorders: integrating herbal medicine and gut microbiome. Tradit Med Res. 2026;11(2):9. doi: 10.53388/TMR20250806001.}
\received{16 January 2025}
\revised{27 February 2025}
\accepted{16 May 2025}
\Availableonline{17 July 2025}
\Executiveeditor{jinlei wang}

%abstract
\tmrabstract{Background: Wenqing Yin (WQY) is a classic prescription used to treat skin diseases like atopic dermatitis (AD) in China, and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD. Methods: The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD. The symptoms of AD in the ears and backs of the mice were assessed, while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction (qRT-PCR), and the percentages of CD4+ and CD8+ cells in the spleen were analyzed through flow cytometry. The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology. Subsequently, the key genes were tested and verified by qRT-PCR, and the potential active components and target proteins were verified by molecular docking. }
\keywords{Wenqing Yin; atopic dermatitis; mouse model; UPLC-Orbitrap-MS/MS; network pharmacology}


\KeywordImage{11.png}

\begin{document}
	\twocolumn
	\begin{highlight}
		\highlightitem{Highlights}{
			Prevotella spp. have emerged as key modulators of host metabolism, exhibiting species-specific effects on gut barrier function, inflammation, and metabolic homeostasis. Recent evidence highlights the potential of high-fiber and herbal interventions to selectively enrich beneficial Prevotella populations. This perspective outlines an ecology-based framework that integrates herbal modulation with microbiota profiling to harness microbe-herb synergy in managing metabolic disorders.
		}
		\highlightitem{Medical history of objective}{
			Traditional Oriental medicine has long regarded the gastrointestinal tract as the foundation of overall health, frequently referring to the spleen–stomach axis as “the foundation of acquired constitution”. Classical texts such as the Huangdi Neijing (compiled in 300–100 B.C.E.) and the Dongui Bogam (compiled in 1610 C.E. by Jun Heo) documented numerous herbal prescriptions designed to enhance digestive function and treat conditions now recognized as metabolic syndromes – characterized by fatigue, obesity, excessive thirst, and impaired digestion. Notably, many of these herbal formulas were historically used to regulate the gastrointestinal environment, “harmonize Qi movement” (keep the body’s energy moving smoothly), and “eliminate internal dampness” (remove extra moisture inside the body), concepts that align with modern understandings of microbial dysbiosis, gut barrier dysfunction, and low-grade systemic inflammation. Contemporary pharmacological research has confirmed that many of these herbs and their active compounds (e.g., berberine, flavonoids, ginsenosides, etc.) can remodel the gut microbiome, modulate Prevotella abundance, and influence bile acid and short-chain fatty acids (SCFAs) pathways.
		}
	\end{highlight}

	\section{Insert A head here}
	This demo file is intended to serve as a ``starter file''. It is for preparing manuscript submission only, not for preparing camera-ready versions of manuscripts. Manuscripts will be typeset for publication by the journal, after they have been accepted.
	
	By default, this template uses \texttt{biblatex} and adopts the Chicago referencing style. However, the journal you’re submitting to may require a different reference style; specify the journal you're using with the class' \texttt{journal} option --- see lines 1--7 of \emph{sample.tex} for a list of options and instructions for selecting the journal. If you are using this template on Overleaf, Overleaf's build tool will automatically run \texttt{pdflatex} and \texttt{biber}. If you are compiling this template on your own local \LaTeX{} installation, please execute the following commands:
	
	\begin{enumerate}
		\item \verb|pdflatex sample|
		\item \verb|biber sample|
		\item \verb|pdflatex sample|
		\item \verb|pdflatex sample|
	\end{enumerate}
	
	Some journals e.g.~\texttt{journal=pasa}
	\\require Bib\TeX{}. For such journals, you will need to
	\begin{itemize}
		\item delete the existing \verb|\addbibresource{example.bib}|;
		\item change the existing \verb|\printbibliography| to be\\
		\verb|\bibliography{example}| instead.
	\end{itemize} 
	
	Overleaf will run \texttt{pdflatex} and \texttt{bibtex} automatically as needed. But if you had \emph{first} compiled using another \texttt{journal} option that adopts \texttt{biblatex}, and \emph{then} change the \texttt{journal} option to one that adopts Bib\TeX{}, you may get some compile error messages instead. In this case you will need to do a `Recompile from scratch'; see \url{https://www.overleaf.com/learn/how-to/Clearing_the_cache}.
	
	On a local \LaTeX{} installation, you would need to run these steps instead:
	\begin{enumerate}
		\item Delete \texttt{sample.aux}, \texttt{sample.bbl} if these files from a previous compile using \texttt{biber} still exist.
		\item \verb|pdflatex sample|
		\item \verb|bibtex sample|
		\item \verb|pdflatex sample|
		\item \verb|pdflatex sample|
	\end{enumerate}
	
	The desired model should also provide measurable feedback describing the degree of metabolic stress experienced. To achieve this, we compared CV values with optical probing of the nicotinamide adenine dinucleotide (NADH/NAD$^{+}$) ratio using the NADH fluorescence signal (fNADH). Based on previous studies \parencite{ref_194007,ref_194008,ref_194009}, we developed a theoretical framework summarizing current strategies for fNADH probing using photobleaching \parencite{ref_194010}. We identified a key gap: the correlation between fNADH dynamics and subsequent tissue function remains unexplored. We adapted and integrated the fNADH probing protocol into the excitation-wave optical mapping protocol. This allowed us to reveal a direct link between local changes in fNADH during metabolic stress and the delayed formation of a conduction block: the developed model made it possible to record the occurrence of a block in the long term, even in its absence, immediately after reperfusion. A comparison of CV maps and fNADH allowed us to test the entire experimental sample for a correlation between these parameters: the resistance of the NADH/NAD$^{+}$ ratio to photobleaching emerged as a potential prognostic parameter within each group and in the entire sample, regardless of the type of metabolic stress (R$^{2}$ = 0.925, \textit{P} < 0.01). Thus, the developed model made it possible to identify and quantitatively represent the cause-and-effect chain between arrhythmogenesis and cardiac tissue remodeling, as well as to assess the capacity of cardiac tissue for controlled adaptation to metabolic stress.

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	\subsection{Insert B head here}
	Subsection text here. Lorem ipsum \parencite{Bayer_etal_2013} dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. 
	
	Lorem ipsum dolor sit amet, consectetur \parencite{Adade_etal_2007} adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Lorem \parencite{ref_186096} ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. 
	
	\subsubsection{Insert C head here}
	Subsubsection text here. Lorem ipsum dolor sit amet, \parencite{ref_186093} consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. 
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	\section{Equations}
	
	Sample equations. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Lorem ipsum dolor sit amet, consectetur\endnote{Another footnote/endnote} adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. 
	
%	\begin{table*}[htb!]
%		\centering
%		\caption{ Results of multiple linear regression analysis of factors influencing fall prevention self-management behavior of older adults in the community (n = 675)} %自定义标题
%		\label{table-1085} % 自定义标签，用于引用
%		\begin{tabular}{cccccccc}
%			\toprule % booktabs包的顶部线条（需加载\usepackage{booktabs}）
%			\headrow % 应用表头背景色（对应之前的LaTeX配置）
%			\textbf{Dependent variable} & \textbf{Independent variable} & \textbf{B-value} & \textbf{S.E.-value} & \textbf{95\% CI} & \textbf{Standardized regression coefficient} & \textit{\textbf{t}}\textbf{-values} & \textit{\textbf{P}}\textbf{ value} \\
%			\midrule
%			\multirow{18}{*}Fall Prevention Self-management (Scores of FPSMB-Q) & Constant & -19.360 & 15.784 & -50.355-11.635 & - & -1.227 & 0.220 \\
%			& \multicolumn{7}{l}Age \\
%			& 70-79 years & 5.379 & 2.644 & 0.187-10.571 & 0.076 & 2.035 & 0.042 \\
%			& \multicolumn{7}{l}Education \\
%			& High school/vocational school & 9.072 & 2.598 & 3.971-14.173 & 0.124 & 3.492 & < 0.001 \\
%			& \multicolumn{7}{l}Medical insurance \\
%			& Urban and rural resident medical insurance & 10.032 & 3.946 & 2.283-17.781 & 0.119 & 2.542 & 0.011 \\
%			& \multicolumn{7}{l}Type of medication taken \\
%			& 1-3 types & 12.253 & 3.766 & 4.858-19.648 & 0.178 & 3.254 & 0.001 \\
%			& ≥ 4 types & 16.677 & 4.928 & 7.001-26.354 & 0.172 & 3.384 & < 0.001 \\
%			& \multicolumn{7}{l}Physical self-assessment status \\
%			& Poor & -10.990 & 5.546 & -21.880--0.100 & -0.091 & -1.982 & 0.048 \\
%			& \multicolumn{7}{l}Fear of falling \\
%			& Not afraid & -8.790 & 2.717 & -14.125--3.456 & -0.118 & -3.236 & 0.001 \\
%			& Knowledge, belief, and practice in preventing falls (Scores of KBP-FP-Q) & 1.940 & 0.159 & 1.628-2.252 & 0.420 & 12.204 & < 0.001 \\
%			& Fall efficacy (Scores of MFES) & 0.100 & 0.042 & 0.018-0.183 & 0.083 & 2.394 & 0.017 \\
%			& Social support (Scores of SSRS) & 0.476 & 0.145 & 0.191-0.761 & 0.119 & 3.276 & 0.01 \\
%			& Fall risk (Scores of CV-SAFRS) & -1.830 & 0.468 & -2.749-0.911 & -0.161 & -3.910 & < 0.001 \\
%			\bottomrule
%		\end{tabular}
%	\end{table*}
	
	
	
	
	
	
	The historical use of \textit{P}\textit{.}\textit{ incarnata} L. dates back to the Late Archaic period in North America (approximately 8000-2000 B.C.). Archaeological findings suggest that Indigenous peoples of the pre-Columbian era cultivated mutual relationships with various plant species, and \textit{P. incarnata} L. frequently thrived as a weedy crop in human-influenced habitats \parencite{ref_186062}. The genus \textit{Passiflora}, established by Linnaeus, includes around 520 species within the family \textit{Passifloraceae}. Most species are climbing plants native to Central and South America, while a few are distributed across North America, Southeast Asia, and Australia \parencite{ref_186063}. Traditionally, \textit{P. incarnata} L. has been valued in herbal medicine across different regions. In Europe, it was primarily used to treat insomnia and anxiety, whereas in North America, it was commonly consumed as a calming tea. In Brazil, the plant served multiple therapeutic purposes, such as acting as an analgesic, antispasmodic, anti-asthmatic, wormicidal, and sedative agent \parencite{ref_186063,ref_186064,ref_186065}. It has also been employed in Iraq as a sedative and narcotic \parencite{ref_186066}, and in Turkey for ailments like dysmenorrhea, epilepsy, neurosis, insomnia, and neuralgia \parencite{ref_186067}. In Poland, it has been prescribed for hysteria and neurasthenia \parencite{ref_186068}, while in the United States, it has been used to alleviate diarrhoea, menstrual pain, neuralgia, burns, haemorrhoids, and sleep disorders \parencite{ref_186051}. In India, \textit{P. incarnata} L. has been administered to individuals with opiate dependence \parencite{ref_186069}.
	%%% Numbered equation
	\begin{equation}
		\begin{aligned}\label{eq:first}
			\frac{\partial u(t,x)}{\partial t} = Au(t,x) \left(1-\frac{u(t,x)}{K}\right)
			-B\frac{u(t-\tau,x) w(t,x)}{1+Eu(t-\tau,x)},\\
			\frac{\partial w(t,x)}{\partial t} =\delta \frac{\partial^2w(t,x)}{\partial x^2}-Cw(t,x)
			+D\frac{u(t-\tau,x)w(t,x)}{1+Eu(t-\tau,x)},
		\end{aligned}
	\end{equation}
	
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	\begin{align}\label{eq:another}
		\begin{split}
			\frac{dU}{dt} &=\alpha U(t)(\gamma -U(t))-\frac{U(t-\tau)W(t)}{1+U(t-\tau)},\\
			\frac{dW}{dt} &=-W(t)+\beta\frac{U(t-\tau)W(t)}{1+U(t-\tau)}.
		\end{split}
	\end{align}
	
	
	%%%% Unnumbered equation
	\begin{align*}
		&\frac{\partial(F_1,F_2)}{\partial(c,\omega)}_{(c_0,\omega_0)} = \left|
		\begin{array}{ll}
			\frac{\partial F_1}{\partial c} &\frac{\partial F_1}{\partial \omega} \\\noalign{\vskip3pt}
			\frac{\partial F_2}{\partial c}&\frac{\partial F_2}{\partial \omega}
		\end{array}\right|_{(c_0,\omega_0)}\\
		&\quad=-4c_0q\omega_0 -4c_0\omega_0p^2 =-4c_0\omega_0(q+p^2)>0.
	\end{align*}
	
	\begin{equation}
		Y_{\theta}^{n+1} = \sum_{w \in X(\theta)} Y^n \left( h_{w}^n, h_{w}, e_{w}^n \right)
	\end{equation}
	
	\begin{equation}
		(Vc - Vt) \times 100 / Vc \tag{3}
	\end{equation}
	
	\section{Figures \& Tables}
	
	The output for a single-column figure is in \autoref{fig:kksim}.  Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Lorem ipsum dolor sit amet, consectetur adipiscing \textcolor{blue}{ $M_{p}=0.749\times\sqrt{N_{\max}}$ } elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. 
	
	Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut \autoref{fig:figwide} labore et dolore magna aliqua. 
	
	%See Figure~\ref{fig_wide} for a double-column figure; this is always at the top of a following page.
	
	
	\begin{figure}[hbt!]
		\centering
		\includegraphics[width=0.75\linewidth]{example-image-16x10.pdf}
		\caption{Insert figure caption here}
		\label{fig:kksim}
	\end{figure}
	
	
	\begin{figure*}
		\centering
		\includegraphics[width=0.8\linewidth]{example-image-16x10.pdf}
		\caption{Insert figure caption here}
		\label{fig:figwide}
	\end{figure*}
	
	
	See example table in \autoref{tab:5566}.
	
	
	
	\section{Conclusion}
	The conclusion text goes here.
	
	\paragraph{Acknowledgments}
	We are grateful for the technical assistance of A. Author.
	
	\paragraph{Funding Statement}
	This research was supported by grants from the <funder-name><doi>(<award ID>); <funder-name><doi>(<award ID>).
	
	\paragraph{Competing Interests}
	A statement about any financial, professional, contractual or personal relationships or situations that could be perceived to impact the presentation of the work --- or `None' if none exist
	
	\paragraph{Data Availability Statement}
	A statement about how to access data, code and other materials allowing users to understand, verify and replicate findings --- e.g. Replication data and \autoref{tt1bl} code can be found in Harvard Dataverse: \verb+\url{https://doi.org/link}+.
	
	\paragraph{Ethical Standards}
	The research meets all ethical guidelines, \autoref{tab:5566} including adherence to the legal requirements of the study country.



\begin{figure*}[htbp]  % 用htbp确保浮动体位置稳定
	\centering  % 整个盒子居中
	% 核心：用minipage包裹所有内容，强制顺序
		% 1. 图片（第一步显示）
		\includegraphics[width=0.9\textwidth]{file_68fd3d0c5df72.png} % 替换你的图片
		
		% 2. 标题（第二步显示）
		\caption{{\fontspec{Calibri}\footnotesize\bfseries\color{figerTitleColor} Transfer Learning Process for 4 Labels Profusion}\\{\vspace{0.5em}\raggedright\small {(a) depicts initialization of a DenseNet-121 model with ImageNet weights to start with a network that already has a good understanding of basic image features and Image (b) depicts the pre-trained weights act as a form of knowledge transfer from the ImageNet task to target domain of Chest X-ray profusion classification task.}}}
		\label{fig:transfer}
\end{figure*}
	
	
	
	

	\begin{table*}[htb!]
		\centering % 必须加：跨栏表格居中，减少溢出
		\label{tab:5566}
		\begin{tblr}{
				% 优化列宽：调整比例，适配长文本自动换行
				colspec={X[0.2,l,cmd=\raggedright] X[1.5,l,cmd=\raggedright] X[1,l,cmd=\raggedright] X[0.8,l,cmd=\raggedright]},
				% 三线表样式
				hline{1}={1.5pt},    
				hline{2}={0.75pt},   
				hline{Z}={1.5pt},    
				% 表头样式：背景为白色（替代none）
				row{1}={font=\bfseries, bg=white}, 
				% 偶数行变色（第2行起）
				row{even[2]}={bg=evenRowColor},
				% 关键：合并单元格强制白色背景（替代none）
				cell{*}{*}={merge={bg=white}},
				% 紧凑间距+自动换行
				rowsep=3pt, % 缩小行间距，减少溢出
				colsep=3pt,
				vlines={0pt}, 
				% 自动换行：避免长文本溢出
				cell{*}{*}={cmd=\raggedright}, % 所有单元格左对齐，自动换行
			}%
			% 表格内容（保留原有结构）
			frou & bbht & sadsa & fdsfds \\
			\SetCell[c=2]{l,bg=white} fdsfds(n=50) & & sdvfdg±SD & fesfsdfds \\
			\SetCell[r=2]{l,bg=white} fdsfd & fdffds(mmol/L) & 5.2±0.8 & 3.9-6.1 \\
			& dfse(mmHg) & 120/80±5 & 90-140/60-90 \\
			\SetCell[c=2]{l,bg=white} fesfe(n=50) & & fesf±SD & fesfef \\
			\SetCell[r=2]{l,bg=white} fefe & fgvcbvc(mmol/L) & 6.8±1.2 & 3.9-6.1 \\
			& sadwadwa(mmHg) & 135/90±8 & 90-140/60-90 \\
			\SetCell[c=3]{l,bg=white} fweafwa & & & <0.05 \\
			\SetCell[c=2]{l,bg=white} fesfe(n=50) & & fesf±SD & fesfef \\
			\SetCell[r=2]{l,bg=white} fefe & fgvcbvc(mmol/L) & 6.8±1.2 & 3.9-6.1 \\
			& sadwadwa(mmHg) & 135/90±8 & 90-140/60-90 \\
			\SetCell[c=3]{c,bg=white} fweafwa & & & <0.05 \\
		\end{tblr}
	\end{table*}
	
	
	\begin{tmrtable*}{}{tab:5566}{X[1] X[0.4] X[0.8]}{1}{}
		\textbf{Cluster-ID} & \textbf{Number of targets} & \textbf{Descriptive} \\
		\SetCell[r=2]{l,bg=white} Cluster 1 & \SetCell[r=2]{l,bg=white} 94 & Human cytomegalovirus infection \\
		Response to lipopolysaccharide \\
		\SetCell[r=3]{l,bg=white} Cluster 2 & \SetCell[r=3]{l,bg=white} 11 & Adenosine P1 receptors \\
		Regulation of amine transport \\
		G protein-coupled adenosine receptor activity \\
		\SetCell[r=2]{l,bg=white} Cluster 3 & \SetCell[r=2]{l,bg=white} 2 & Muscarinic acetylcholine receptors \\
		Saliva secretion \\
	\end{tmrtable*}
	
	
	
	\paragraph{Author Contributions}
	Please provide an author contributions statement using the CRediT taxonomy roles as a guide {\verb+\url{https://www.casrai.org/credit.html}+}. Conceptualization: A.A; A.B. Methodology: A.A; A.B. Data curation: A.C. Data visualisation: A.C. Writing original draft: A.A; A.B. All authors approved the final submitted draft.
	
	%\endnote in some journals will behave like \footnote; and \printendnotes will not output anything. 
%	\printendnotes
%	
%	
%	\defbibnote{preamble}{By default, this template uses \texttt{biblatex} and adopts the Chicago referencing style. However, the journal you’re submitting to may require a different reference style; specify the journal you're using with the class' \texttt{journal} option --- see lines 1--8 of \emph{sample.tex} for a list of options and instructions for selecting the journal.}
	
	\nocite{*}
	\printbibliography[title={References}]
	
%	\appendix
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%	\section{Example Appendix Section}
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\end{document}