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1. The ef-fec-tive-ness and di-ver-sity of tra-di-tion al Chi-nese [] -Underfull \hbox (badness 10000) in paragraph at lines 77--77 +Underfull \hbox (badness 10000) in paragraph at lines 76--76 [] -Underfull \hbox (badness 1147) in paragraph at lines 77--77 +Underfull \hbox (badness 1147) in paragraph at lines 76--76 \TU/Calibri(0)/m/n/8 of lung dis-eases. For in-stance, the flower buds of \TU/C alibri(0)/m/it/8 Tus-si-lago [] -Package mdframed Info: Not enough space on this page on input line 77. +Package mdframed Info: Not enough space on this page on input line 76. 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These + [] + + +Underfull \hbox (badness 6944) in paragraph at lines 93--93 +[]\TU/CharisSIL(1)/m/n/8 CS, pathogens, and var-i-ous en-vi-ron-men-tal ex-po-su +res are + [] + + +Underfull \hbox (badness 1622) in paragraph at lines 93--93 +\TU/CharisSIL(1)/m/n/8 of COPD; no-tably, the re-moval of these risk fac-tors ha +s the + [] + + +Underfull \hbox (badness 2653) in paragraph at lines 93--93 +\TU/CharisSIL(1)/m/n/8 po-ten-tial to halt the patho-log-i-cal pro-gres-sion of the dis-ease + [] + + +Underfull \hbox (badness 1406) in paragraph at lines 93--93 +\TU/CharisSIL(1)/m/n/8 in-fec-tions, also sig-nif-i-cantly con-tribute to the pa +tho-gen-e-sis of + [] + + +Underfull \hbox (badness 1442) in paragraph at lines 93--93 +\TU/CharisSIL(1)/m/n/8 parenchyma, also known as em-phy-sema [][18, 19][]. COPD is + [] + + +Underfull \hbox (badness 1072) in paragraph at lines 93--93 +\TU/CharisSIL(1)/m/n/8 com-pli-cat-edly reg-u-lated by var-i-ous bi-o-log-i-cal mech-a-nisms and + [] + + +Underfull \hbox (badness 1635) in paragraph at lines 93--93 +\TU/CharisSIL(1)/m/n/8 their crosstalk, in-clud-ing ox-ida-tive stress, in-flam- +ma-tion, ECM + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 3623) in paragraph at lines 97--97 +\TU/CharisSIL(1)/m/n/8 a large amount of ox-i-dants, lead-ing to the in-ac-ti-va +-tion of + [] + + +Underfull \hbox (badness 3547) in paragraph at lines 97--97 +\TU/CharisSIL(1)/m/n/8 of mu-cus genes like mucin 5AC (\TU/CharisSIL(0)/m/it/8 +MUC5AC\TU/CharisSIL(1)/m/n/8 ) and mucin 5B + [] + + +Underfull \hbox (badness 1565) in paragraph at lines 97--97 +\TU/CharisSIL(1)/m/n/8 (\TU/CharisSIL(0)/m/it/8 MUC5B\TU/CharisSIL(1)/m/n/8 ) [ +][[]10[]–[]12[]][]. Epi-der-mal growth fac-tor re-cep-tor (EGFR) + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 6944) in paragraph at lines 97--97 +\TU/CharisSIL(1)/m/n/8 fac-tor, and nu-clear fac-tor kappa-B (NF-κ󰀀B). These + fac-tors + [] + + +Underfull \hbox (badness 4013) in paragraph at lines 97--97 +[]\TU/CharisSIL(1)/m/n/8 [[]16[]][]. How-ever, ox-ida-tive stress can di-rectly pro-mote the + [] + + +Underfull \hbox (badness 7704) in paragraph at lines 97--97 +\TU/CharisSIL(1)/m/n/8 phos-pho-ry-la-tion and ubiq-ui-ti-na-tion of hi-s-tone +deacetylase-2 [] -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! [2 -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! ] -Underfull \hbox (badness 1221) in paragraph at lines 102--102 -\TU/lmr/m/n/8 In the air-way lu-men of COPD pa-tients, in-flam-ma-tion is - [] - -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! - -Underfull \hbox (badness 1377) in paragraph at lines 106--106 -\TU/lmr/m/n/8 pro-mote bron-chi-o-lar and alve-o-lar ep-ithe-lial cell mi-gra-ti -on - [] - -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -[3 -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -<./image/file_682161fb0fcfd.png>] -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! - -Underfull \hbox (badness 2057) in paragraph at lines 111--111 -\TU/lmr/m/n/8 in the treat-ment of COPD due to its in-her-ent nat-u-ral +Underfull \hbox (badness 1454) in paragraph at lines 102--102 +[]\TU/CharisSIL(1)/m/n/8 CS stim-u-lates both air-way ep-ithe-lial cells and mac +rophages [] -Underfull \hbox (badness 1521) in paragraph at lines 111--111 -\TU/lmr/m/n/8 as the prin-ci-pal con-stituents of nat-u-ral in-gre-di-ents, of-f -er +Underfull \hbox (badness 1107) in paragraph at lines 102--102 +\TU/CharisSIL(1)/m/n/8 to pro-duce a range of chemo-tac-tic cy-tokines and chemo +kines, [] -Underfull \hbox (badness 3199) in paragraph at lines 111--111 -\TU/lmr/m/n/8 out-stand-ing anti-inflammatory and an-tiox-i-dant prop-er-ties, +Underfull \hbox (badness 1584) in paragraph at lines 102--102 +\TU/CharisSIL(1)/m/n/8 cas-cades that in-duce macrophage po-lar-ized to M1 phe-n +o-type, [] -<./image/image-60721.png, id=155, 4063.18pt x 5986.365pt> + +Underfull \hbox (badness 1460) in paragraph at lines 102--102 +\TU/CharisSIL(1)/m/n/8 which in-deed pro-duces pro-inflammatory cy-tokines. Such + as, + [] + + +Underfull \hbox (badness 2012) in paragraph at lines 102--102 +\TU/CharisSIL(1)/m/n/8 con-nec-tive tis-sue and elastin in the alve-oli, lead-in +g to both + [] + + +Underfull \hbox (badness 2205) in paragraph at lines 102--102 +\TU/CharisSIL(1)/m/n/8 ep-ithe-lium, smooth mus-cle and fi-brob-lasts. Thus, bot +h the + [] + + +Underfull \hbox (badness 10000) in paragraph at lines 105--105 +\TU/CharisSIL(1)/m/n/8 phase in-duced by per-sis-tent in-flam-ma-tory stim-u-la- +tion and + [] + + +Underfull \hbox (badness 2653) in paragraph at lines 105--105 +\TU/CharisSIL(1)/m/n/8 vas-cu-lar per-me-abil-ity, al-low-ing fib-rino-gen and +fi-bronectin to + [] + + +Underfull \hbox (badness 1132) in paragraph at lines 105--105 +\TU/CharisSIL(1)/m/n/8 epi-der-mal growth fac-tors (EGF) and chemokines to en-co +ur-age + [] + + +Underfull \hbox (badness 5231) in paragraph at lines 105--105 +\TU/CharisSIL(1)/m/n/8 sub-se-quently fa-cil-i-tates epithelial-mesenchymal tran +-si-tion and + [] + + +Underfull \hbox (badness 1983) in paragraph at lines 105--105 +\TU/CharisSIL(1)/m/n/8 pro-motes the dif-fer-en-ti-a-tion of fi-brob-lasts into my-ofi-brob-lasts + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 2027) in paragraph at lines 106--106 +\TU/CharisSIL(1)/m/n/8 (EMT) by up-regulating NF-κ󰀀B sig-nalling, toll-like re-cep-tor 4 + [] + +[3<./image/file_682161fb0fcfd.png>] +Underfull \hbox (badness 1205) in paragraph at lines 110--110 +\TU/CharisSIL(1)/m/n/8 the treat-ment of COPD due to its in-her-ent nat-u-ral pr +op-er-ties + [] + + +Underfull \hbox (badness 2961) in paragraph at lines 110--110 +\TU/CharisSIL(1)/m/n/8 and demon-strated ef-fi-cacy. Note-wor-thy, flavonoids, +as the + [] + + +Underfull \hbox (badness 1377) in paragraph at lines 110--110 +\TU/CharisSIL(1)/m/n/8 prin-ci-pal con-stituents of nat-u-ral in-gre-di-ents, of +-fer out-stand-ing + [] + + +Underfull \hbox (badness 7030) in paragraph at lines 110--110 +\TU/CharisSIL(1)/m/n/8 in-ter-est and at-ten-tion in sci-en-tific and in-dus-tri +al do-mains. + [] + +<./image/image-60721.png, id=154, 4063.18pt x 5986.365pt> File: ./image/image-60721.png Graphic file (type png) -Package luatex.def Info: ./image/image-60721.png used on input line 116. +Package luatex.def Info: ./image/image-60721.png used on input line 115. (luatex.def) Requested size: 439.93333pt x 648.08893pt. -Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;! +Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! -Underfull \hbox (badness 1231) in paragraph at lines 121--121 -\TU/lmr/m/n/8 their over-all care plan. Specif-i-cally, flavonoids have the +Underfull \hbox (badness 1242) in paragraph at lines 120--120 +\TU/CharisSIL(1)/m/n/8 air-way and lung in-flam-ma-tion, im-prov-ing air-way re- +mod-elling, [] -Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;! +Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! -Underfull \hbox (badness 1902) in paragraph at lines 127--127 -\TU/lmr/m/n/8 (SOD), and glu-tathione per-ox-i-dase (GSH-Px), while also +Underfull \hbox (badness 1502) in paragraph at lines 126--126 +[]\TU/CharisSIL(1)/m/n/8 Flavonoids have been re-ported to pre-vent and in-hibit + lung [] -Underfull \hbox (badness 1127) in paragraph at lines 128--128 -\TU/lmr/m/n/8 an-tiox-i-dant ac-tiv-ity. In pa-tients with COPD, low lev-els +Underfull \hbox (badness 1248) in paragraph at lines 126--126 +\TU/CharisSIL(1)/m/n/8 an-tiox-i-dant ca-pac-ity by in-creas-ing the lev-els and + ac-tiv-i-ties of [] -Underfull \hbox (badness 1817) in paragraph at lines 128--128 -\TU/lmr/m/n/8 stress, Nrf2 is re-leased and translo-cated to the nu-cleus, +Underfull \hbox (badness 4467) in paragraph at lines 126--126 +\TU/CharisSIL(1)/m/n/8 an-tiox-i-dant en-zymes such as cata-lase, su-per-ox-ide dis-mu-tase [] -Underfull \hbox (badness 1325) in paragraph at lines 128--128 -\TU/lmr/m/n/8 where it ini-ti-ates the tran-scrip-tion of var-i-ous an-tiox-i-da -nt +Underfull \hbox (badness 1400) in paragraph at lines 126--126 +\TU/CharisSIL(1)/m/n/8 ROS-generating en-zymes like xan-thine ox-i-dase. For ex- +am-ple, [] -<./image/file_67aee377039e2.jpg, id=169, 2554.29282pt x 1939.245pt> + +Underfull \hbox (badness 2443) in paragraph at lines 126--126 +\TU/CharisSIL(1)/m/n/8 by en-hanc-ing SOD, haem oxy-ge-nase 1 (HO-1) and re-duc- +ing + [] + + +Underfull \hbox (badness 2452) in paragraph at lines 126--126 +\TU/CharisSIL(1)/m/n/8 and al-ka-line phos-phatase in a rat model of PM$[][]$ ex +-po-sure + [] + + +Underfull \hbox (badness 1067) in paragraph at lines 126--126 +[]\TU/CharisSIL(1)/m/n/8 [[]80[]][]. Api-genin en-hanced the ac-ti-va-tion of si +lent in-for-ma-tion + [] + + +Underfull \hbox (badness 3291) in paragraph at lines 127--127 +\TU/CharisSIL(1)/m/n/8 fac-tor that gov-erns the ex-pres-sion of genes as-so-ci- +ated with + [] + + +Underfull \hbox (badness 1742) in paragraph at lines 127--127 +\TU/CharisSIL(1)/m/n/8 in the cy-to-plasm. How-ever, un-der ox-ida-tive stress, Nrf2 is + [] + + +Underfull \hbox (badness 1360) in paragraph at lines 128--128 +\TU/CharisSIL(1)/m/n/8 ef-fects on air-way ep-ithe-lial cells and in-flam-ma-tor +y cells. In + [] + + +Underfull \hbox (badness 4328) in paragraph at lines 128--128 +\TU/CharisSIL(1)/m/n/8 sum-mary, flavonoids were found to in-hibit ox-ida-tive +stress + [] + + +Underfull \hbox (badness 1418) in paragraph at lines 128--128 +\TU/CharisSIL(1)/m/n/8 cells, The mech-a-nism of ac-tion can be vi-su-ally il-lu +s-trated in + [] + + +Underfull \hbox (badness 3503) in paragraph at lines 128--128 +\TU/CharisSIL(1)/m/n/8 in CS-damaged RAW 264.7 cells [][[]37[]][]. Lu-te-olin de +-creased + [] + +<./image/file_67aee377039e2.jpg, id=168, 2554.29282pt x 1939.245pt> File: ./image/file_67aee377039e2.jpg Graphic file (type jpg) -Package luatex.def Info: ./image/file_67aee377039e2.jpg used on input line 133 +Package luatex.def Info: ./image/file_67aee377039e2.jpg used on input line 132 . (luatex.def) Requested size: 439.93333pt x 333.9875pt. -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Underfull \hbox (badness 1577) in paragraph at lines 140--140 -\TU/lmr/m/n/8 In-flam-ma-tion is a vi-tal com-po-nent in the ini-ti-a-tion and +Underfull \hbox (badness 1755) in paragraph at lines 135--135 +[]\TU/CharisSIL(1)/m/n/8 In mice and rat mod-els of COPD, var-i-ous flavonoids +have [] -Underfull \hbox (badness 5652) in paragraph at lines 140--140 -\TU/lmr/m/n/8 ad-vance-ment of COPD. The in-fil-tra-tion of neu-trophils - [] - -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! - -Underfull \hbox (badness 2512) in paragraph at lines 140--140 -\TU/lmr/m/n/8 cells and the alve-o-lar ep-ithe-lium [][[]101[]][]. IL-6 ac-ti-va -tes +Underfull \hbox (badness 1028) in paragraph at lines 135--135 +\TU/CharisSIL(1)/m/n/8 like-wise been proved to in-hibit the de-vel-op-ment of +COPD by [] -Underfull \hbox (badness 2150) in paragraph at lines 140--140 -\TU/lmr/m/n/8 in-duce pul-monary edema [][[]102[]][]. Ad-di-tion-ally, mono-cyte - +Underfull \hbox (badness 1596) in paragraph at lines 135--135 +\TU/CharisSIL(1)/m/n/8 In a CS-induced mouse model, isoliquir-it-i-genin re-duce +d MDA [] -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! + +Underfull \hbox (badness 2799) in paragraph at lines 135--135 +\TU/CharisSIL(1)/m/n/8 lev-els by en-hanc-ing the ex-pres-sion of Nrf2 and HO-1 [][[]32[]][]. + [] + + +Underfull \hbox (badness 1342) in paragraph at lines 135--135 +\TU/CharisSIL(1)/m/n/8 en-zymes such as SOD, GSH [][[]48[]][]. Epi-cat-e-chin re +-pressed the + [] + + +Underfull \hbox (badness 1097) in paragraph at lines 139--139 +\TU/CharisSIL(1)/m/n/8 cor-re-la-tion with the sever-ity of air-flow ob-struc-ti +on. Harm-ful + [] + + +Underfull \hbox (badness 2707) in paragraph at lines 139--139 +\TU/CharisSIL(1)/m/n/8 sub-stances in-duce the res-pi-ra-tory tract ep-ithe-lium + to se-crete + [] + + +Underfull \hbox (badness 4981) in paragraph at lines 139--139 +[]\TU/CharisSIL(1)/m/n/8 [[]101[]][]. IL-6 ac-ti-vates neu-trophils, re-leas-ing + NE and ROS, + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 7631) in paragraph at lines 140--140 +\TU/CharisSIL(1)/m/n/8 in-flam-ma-tory dis-eases, ef-fec-tively in-hibit-ing the + on-set and + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! [4 -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! ] [5<./image/image-60721.png>] -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-bold]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-italic]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-italic]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-bold]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-italic]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-italic]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-bold]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-bold]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-italic]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-italic]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-italic]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-italic]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -<./image/file_68999e3c72e62.png, id=213, 2990.7735pt x 2295.17474pt> +Missing character: There is no κ (U+03BA) in font "name:Charis SIL Bold:mode=no +de;script=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL Bold:mode=no +de;script=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL Bold:mode=no +de;script=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 1831) in paragraph at lines 141--141 +[]\TU/CharisSIL(0)/b/n/8 Tar-get-ing NF-κ󰀀B path-way. \TU/CharisSIL(1)/m/n/ +8 The ac-ti-va-tion of the NF-κ󰀀B + [] + + +Underfull \hbox (badness 2772) in paragraph at lines 141--141 +\TU/CharisSIL(1)/m/n/8 path-way is be-lieved to play a piv-otal role in in-flam- +ma-tory + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +<./image/file_68999e3c72e62.png, id=212, 2990.7735pt x 2295.17474pt> File: ./image/file_68999e3c72e62.png Graphic file (type png) -Package luatex.def Info: ./image/file_68999e3c72e62.png used on input line 146 +Package luatex.def Info: ./image/file_68999e3c72e62.png used on input line 145 . (luatex.def) Requested size: 439.93333pt x 337.60727pt. -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no ĸ (U+0138) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no ĸ (U+0138) in font [lmroman8-regular]:+tlig;! -Missing character: There is no ĸ (U+0138) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 3049) in paragraph at lines 148--148 +\TU/CharisSIL(1)/m/n/8 mod-u-late NF-κ󰀀B sig-nalling in COPD, ac-knowl-edg-i +ng NF-κ󰀀B’s + [] + + +Underfull \hbox (badness 1776) in paragraph at lines 148--148 +\TU/CharisSIL(1)/m/n/8 p-p65 but in-creas-ing Nrf2 in LPS-induced BEAS-2B cell +[][[]52[]][]. + [] + + +Underfull \hbox (badness 1303) in paragraph at lines 148--148 +\TU/CharisSIL(1)/m/n/8 pro-duc-tion and in-flam-ma-tion me-di-a-tor lev-els (COX +-2, NADPH + [] + + +Underfull \hbox (badness 1783) in paragraph at lines 148--148 +\TU/CharisSIL(1)/m/n/8 ox-i-dase 4 (NOX4), NOS2, IL-6 and IL-8) by sup-press-ing + the + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 1221) in paragraph at lines 149--149 +\TU/CharisSIL(1)/m/n/8 of in-flam-ma-tory cells and pro-inflammatory cy-tokines such as + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 1348) in paragraph at lines 151--151 +\TU/CharisSIL(1)/m/n/8 in the COPD co-infection model. Upon stim-u-la-tion, myel +oid + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 1540) in paragraph at lines 151--151 +\TU/CharisSIL(1)/m/n/8 COPD rat model, baicalin re-duced TLR2 and TLR4, fol-lowe +d + [] + + +Underfull \hbox (badness 1902) in paragraph at lines 151--151 +\TU/CharisSIL(1)/m/n/8 by low-er-ing MYD88, phos-pho-ry-la-tion of p65, and in-c +reas-ing + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 3803) in paragraph at lines 151--151 +[]\TU/CharisSIL(1)/m/n/8 [[]51[]][]. TLRs are cru-cial tar-gets of flavonoids in + in-hibit-ing + [] + [6 -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-bold]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-italic]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-italic]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no ĸ (U+0138) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL Bold:mode=no +de;script=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! <./image/file_67aee377039e2.jpg>] -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 2376) in paragraph at lines 152--152 +\TU/CharisSIL(1)/m/n/8 lo-cal-i-sa-tions and func-tions, is the first sir-tuin +that reg-u-lates + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 2205) in paragraph at lines 153--153 +\TU/CharisSIL(1)/m/n/8 through down-regulating air-way in-flam-ma-tory in-fil-tr +a-tion and + [] + + +Underfull \hbox (badness 1275) in paragraph at lines 153--153 +\TU/CharisSIL(1)/m/n/8 de-creas-ing the in-flam-ma-tory fac-tors (the lev-els of + TNF-α and + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 1132) in paragraph at lines 154--154 +[]\TU/CharisSIL(1)/m/n/8 To-tal flavonoid ex-tract also has the ef-fect of in-hi +bit-ing the + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 1895) in paragraph at lines 154--154 +\TU/CharisSIL(1)/m/n/8 NF-κ󰀀B path-way. For ex-am-ple, to-tal flavonoids fro +m \TU/CharisSIL(0)/m/it/8 Nigella + [] + + +Underfull \hbox (badness 1642) in paragraph at lines 154--154 +\TU/CharisSIL(1)/m/n/8 of neu-trophils and macrophages into the lung and de-crea +sed + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 3219) in paragraph at lines 154--154 +\TU/CharisSIL(1)/m/n/8 flavonoids from lo-quat (\TU/CharisSIL(0)/m/it/8 Eri-obot +rya japon-ica\TU/CharisSIL(1)/m/n/8 ) leaves al-le-vi-ated + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 4291) in paragraph at lines 155--155 +[]\TU/CharisSIL(0)/b/n/8 Tar-get-ing MAPK path-way. \TU/CharisSIL(1)/m/n/8 MAPKs + rep-re-sent a di-verse + [] + + +Underfull \hbox (badness 5475) in paragraph at lines 155--155 +\TU/CharisSIL(1)/m/n/8 trans-duc-tion path-ways. The MAPK fam-ily com-prises fou +r + [] + + +Underfull \hbox (badness 2662) in paragraph at lines 155--155 +\TU/CharisSIL(1)/m/n/8 sub-fam-i-lies: ex-tra-cel-lu-lar reg-u-lated pro-tein ki +-nases (ERK)1/2 + [] + + +Underfull \hbox (badness 2213) in paragraph at lines 155--155 +\TU/CharisSIL(1)/m/n/8 (ex-tra-cel-lu-lar signal-regulated ki-nases 1 and 2), ER +K5, JNKs, + [] + + +Underfull \hbox (badness 1052) in paragraph at lines 155--155 +\TU/CharisSIL(1)/m/n/8 and p38s (p38 MAPKs). No-tably, p38 MAPK is ac-ti-vated +in + [] + + +Underfull \hbox (badness 1122) in paragraph at lines 156--156 +\TU/CharisSIL(1)/m/n/8 the in-hi-bi-tion of the ERK, p38, and JNK sig-nalling pa +th-ways + [] + + +Underfull \hbox (badness 1253) in paragraph at lines 156--156 +[]\TU/CharisSIL(1)/m/n/8 [[]72[]][]. Sily-marin sig-nif-i-cantly al-le-vi-ated +the thick-en-ing of the + [] + [7 -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no δ (U+03B4) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! <./image/file_68999e3c72e62.png>] -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! - -Underfull \hbox (badness 1383) in paragraph at lines 157--157 -\TU/lmr/m/n/8 of the air-way ep-ithe-lium and in-fil-tra-tion of peri-bronchial - [] - -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! - -Underfull \hbox (badness 1342) in paragraph at lines 160--160 -\TU/lmr/m/n/8 and p38 ex-pres-sion and de-creas-ing mucin ex-pres-sion and +Underfull \hbox (badness 1048) in paragraph at lines 157--157 +[]\TU/CharisSIL(1)/m/n/8 Bac-te-rial in-fec-tion stands as a pri-mary cul-prit +be-hind acute [] -Underfull \hbox (badness 3612) in paragraph at lines 160--160 -\TU/lmr/m/n/8 in-flam-ma-tion [][[]30[]][]. In the LPS-induced air-way mu-cus - [] - -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! - -Underfull \hbox (badness 1122) in paragraph at lines 160--160 -\TU/lmr/m/n/8 air-way ep-ithe-lial cells. How-ever, it did not af-fect A549 +Underfull \hbox (badness 1845) in paragraph at lines 157--157 +\TU/CharisSIL(1)/m/n/8 al-le-vi-ate the patho-log-i-cal in-flam-ma-tion as-so-ci +-ated with COPD [] -Underfull \hbox (badness 1221) in paragraph at lines 161--161 -\TU/lmr/m/n/8 of COPD is char-ac-ter-ized by the per-sis-tent mi-gra-tion of +Underfull \hbox (badness 2277) in paragraph at lines 158--158 +\TU/CharisSIL(1)/m/n/8 are es-sen-tial for caus-ing and pro-mot-ing var-i-ous ce +ll growth, [] -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -<./image/zipimg67aea6fbb71406.png, id=299, 4328.17pt x 2634.84375pt> +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 3930) in paragraph at lines 159--159 +\TU/CharisSIL(1)/m/n/8 re-duced the ex-pres-sion level of MUC5AC by in-hibit-ing + the + [] + + +Underfull \hbox (badness 1939) in paragraph at lines 159--159 +\TU/CharisSIL(1)/m/n/8 ac-ti-va-tion of the EGFR, as ev-i-denced by de-creased +lev-els of + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 2486) in paragraph at lines 159--159 +\TU/CharisSIL(1)/m/n/8 tilianin also re-duced MUC5AC ex-pres-sion by mod-u-lat-i +ng the + [] + + +Underfull \hbox (badness 1107) in paragraph at lines 159--159 +\TU/CharisSIL(1)/m/n/8 cells [][[]77[]][]. Fur-ther-more, icariin was shown to +pro-mote lung + [] + + +Underfull \hbox (badness 1342) in paragraph at lines 161--161 +\TU/CharisSIL(1)/m/n/8 and mono-cyte chemo-tac-tic protein-1 lev-els in bron-cho +alve-o-lar + [] + + +Underfull \hbox (badness 1484) in paragraph at lines 161--161 +\TU/CharisSIL(1)/m/n/8 and al-le-vi-ated gob-let cells meta-pla-sia and em-phy-s +e-ma-tous by + [] + + +Underfull \hbox (badness 3118) in paragraph at lines 161--161 +\TU/CharisSIL(1)/m/n/8 cells (such as leuko-cytes, to-tal lym-pho-cytes, CD11b$ +[][]$CD11c$[][]$ + [] + + +Underfull \hbox (badness 2393) in paragraph at lines 161--161 +\TU/CharisSIL(1)/m/n/8 sig-nal path-ways in the COPD mice model [][[]78[]][]. Gi +nkgetin + [] + + +Underfull \hbox (badness 1107) in paragraph at lines 161--161 +\TU/CharisSIL(1)/m/n/8 path-way in CSE-induced A549 cells, which is as-so-ci-ate +d with + [] + +<./image/zipimg67aea6fbb71406.png, id=300, 4328.17pt x 2634.84375pt> File: ./image/zipimg67aea6fbb71406.png Graphic file (type png) Package luatex.def Info: ./image/zipimg67aea6fbb71406.png used on input line 1 -69. +68. (luatex.def) Requested size: 439.93333pt x 267.80168pt. -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-italic]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-italic]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-italic]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! + +Underfull \hbox (badness 1292) in paragraph at lines 171--171 +\TU/CharisSIL(1)/m/n/8 them, MMPs are a promi-nent and in-flu-en-tial fam-ily. +Tis-sue + [] + + +Underfull \hbox (badness 1237) in paragraph at lines 171--171 +\TU/CharisSIL(1)/m/n/8 of MMPs; usu-ally, TIMP-1 in-hibits ac-tive MMPs, and TIM +P-1 + [] + + +Underfull \hbox (badness 1817) in paragraph at lines 171--171 +\TU/CharisSIL(1)/m/n/8 binds to pro-MMP-9 to pre-vent the ac-ti-va-tion of pro-M +MP-9. + [] + + +Underfull \hbox (badness 1490) in paragraph at lines 173--173 +\TU/CharisSIL(1)/m/n/8 as \TU/CharisSIL(0)/m/it/8 α-SMA \TU/CharisSIL(1)/m/n/8 + and col-la-gen. This pro-cess al-ters the EMT [][[]119[]][]. + [] + + +Underfull \hbox (badness 1033) in paragraph at lines 174--174 +\TU/CharisSIL(1)/m/n/8 im-prov-ing lung func-tion [][[]33[]][]. In four-day CS-e +xposure mice, + [] + [8 -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no γ (U+03B3) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-italic]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! ] -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! - -Underfull \hbox (badness 1997) in paragraph at lines 178--178 -\TU/lmr/bx/n/8 Tar-get-ing apop-to-sis. \TU/lmr/m/n/8 Apop-to-sis is a phys-i-o- -log-i-cal or - [] - -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -[9 -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -<./image/zipimg67aea6fbb71406.png>] -Underfull \hbox (badness 2285) in paragraph at lines 181--181 -\TU/lmr/m/n/8 through iron chela-tion and in-ter-ac-tion with the en-zyme +Underfull \hbox (badness 2418) in paragraph at lines 177--177 +\TU/CharisSIL(1)/m/n/8 re-sponse of cells to var-i-ous stim-uli, in-clud-ing DNA + dam-age, [] -Underfull \hbox (badness 3029) in paragraph at lines 181--181 -\TU/lmr/m/n/8 arachi-do-nate 15-lipoxygenase, which is in-volved in fatty - [] - -Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! - -Underfull \hbox (badness 10000) in paragraph at lines 193--193 -[]\TU/lmr/m/n/8 A va-ri-ety of flavonoids have been de-vel-oped into +Underfull \hbox (badness 1048) in paragraph at lines 178--178 +\TU/CharisSIL(1)/m/n/8 apop-to-sis in the patho-gen-e-sis of COPD. For in-stance +, baicalin [] -Underfull \hbox (badness 5008) in paragraph at lines 193--193 -\TU/lmr/m/n/8 phar-ma-ceu-ti-cals, cos-met-ics, and health foods, such as +Underfull \hbox (badness 1107) in paragraph at lines 178--178 +\TU/CharisSIL(1)/m/n/8 apop-to-sis in CSE-treated MLE-12 cells, which are mouse lung [] -Underfull \hbox (badness 2096) in paragraph at lines 202--202 -[]\TU/lmr/m/n/8 This work was sup-ported by the Shan-dong Provin-cial +Underfull \hbox (badness 1540) in paragraph at lines 178--178 +\TU/CharisSIL(1)/m/n/8 type II ep-ithe-lial cells [][[]66[]][]. Ad-di-tion-ally, + baicalin mit-i-gates [] -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Underfull \hbox (badness 1178) in paragraph at lines 206--206 -\TU/lmr/m/n/8 smoke; ROS, re-ac-tive oxy-gen species; ECM, ex-tra-cel-lu-lar +Underfull \hbox (badness 1087) in paragraph at lines 178--178 +\TU/CharisSIL(1)/m/n/8 flavonoids reg-u-late autophagy-related apop-to-sis. Puer +-arin has [] -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Underfull \hbox (badness 1314) in paragraph at lines 206--206 -\TU/lmr/m/n/8 ma-trix; EGFR, epi-der-mal growth fac-tor re-cep-tor; NF-κ󰀀B, +Underfull \hbox (badness 1521) in paragraph at lines 178--178 +\TU/CharisSIL(1)/m/n/8 been demon-strated to in-hibit FUNDC1-mediated mi-to-chon +-drial [] -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Underfull \hbox (badness 1237) in paragraph at lines 206--206 -\TU/lmr/m/n/8 mo-tif chemokine lig-and; NE, neu-trophil elas-tase; MAPK, +Underfull \hbox (badness 1024) in paragraph at lines 178--178 +\TU/CharisSIL(1)/m/n/8 Puer-arin also pro-tects lung func-tion and in-hibits apo +p-to-sis by + [] + + +Underfull \hbox (badness 1521) in paragraph at lines 178--178 +\TU/CharisSIL(1)/m/n/8 down-regulating the Bax level and up-regulating Bcl-2 in the + [] + + +Underfull \hbox (badness 1939) in paragraph at lines 178--178 +\TU/CharisSIL(1)/m/n/8 lung, a pro-cess that de-pends on the PINK1-parkin sig-na +lling + [] + + +Underfull \hbox (badness 1132) in paragraph at lines 179--179 +\TU/CharisSIL(1)/m/n/8 Ad-di-tion-ally, acyl-CoA syn-thetase long-chain fam-ily mem-ber 4 + [] + + +Underfull \hbox (badness 2229) in paragraph at lines 180--180 +[]\TU/CharisSIL(1)/m/n/8 Scutel-larein may help treat COPD by in-hibit-ing fer-r +op-to-sis + [] + + +Underfull \hbox (badness 10000) in paragraph at lines 180--180 +\TU/CharisSIL(1)/m/n/8 through iron chela-tion and in-ter-ac-tion with the en-zy +me + [] + + +Underfull \hbox (badness 1389) in paragraph at lines 180--180 +\TU/CharisSIL(1)/m/n/8 arachi-do-nate 15-lipoxygenase, which is in-volved in fat +ty acid + [] + + +Underfull \hbox (badness 2293) in paragraph at lines 180--180 +\TU/CharisSIL(1)/m/n/8 lethal small molecule 3-induced fer-rop-to-sis and mi-to- +chon-dria + [] + + +Underfull \hbox (badness 2753) in paragraph at lines 180--180 +\TU/CharisSIL(1)/m/n/8 It no-tably im-peded the in-creas-ing of lipid per-ox-i-d +a-tion and + [] + + +Underfull \hbox (badness 3343) in paragraph at lines 180--180 +\TU/CharisSIL(1)/m/n/8 mor-pho-log-i-cal changes in the mi-to-chon-dria by up-re +gulating + [] + + +Underfull \hbox (badness 1082) in paragraph at lines 180--180 +\TU/CharisSIL(1)/m/n/8 SLC7A11, GPx4, and SOD by down-regulating MDA and ROS + [] + + +Underfull \hbox (badness 1019) in paragraph at lines 180--180 +\TU/CharisSIL(1)/m/n/8 level of CSE-induced alve-o-lar macrophages and in-hib-it +ed lung + [] + + +Underfull \hbox (badness 1552) in paragraph at lines 180--180 +\TU/CharisSIL(1)/m/n/8 by chelat-ing iron and ac-ti-vat-ing the down-stream anti +-oxidant + [] + +[9<./image/zipimg67aea6fbb71406.png>] +Underfull \hbox (badness 1430) in paragraph at lines 183--183 +\TU/CharisSIL(1)/m/n/8 Flavonoids have a long his-tory of con-sump-tion in di-et +s with + [] + +Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 1303) in paragraph at lines 191--191 +\TU/CharisSIL(1)/m/n/8 ther-a-peu-tic ef-fects on COPD vary sig-nif-i-cantly. No +-tably, the + [] + + +Underfull \hbox (badness 1502) in paragraph at lines 191--191 +\TU/CharisSIL(1)/m/n/8 num-ber and po-si-tion of hy-droxyl groups in-flu-ence fl +avonoids’ + [] + + +Underfull \hbox (badness 4543) in paragraph at lines 191--191 +\TU/CharisSIL(1)/m/n/8 rep-re-sents an-other im-por-tant struc-tural fea-ture th +at im-pacts + [] + + +Underfull \hbox (badness 2460) in paragraph at lines 192--192 +\TU/CharisSIL(1)/m/n/8 cos-met-ics, and health foods, such as ginkgo flavonoids, + tea + [] + + +Underfull \hbox (badness 2717) in paragraph at lines 193--193 +\TU/CharisSIL(1)/m/n/8 which flavonoid is most suit-able for COPD ther-apy re-ma +ins + [] + + +Underfull \hbox (badness 1107) in paragraph at lines 193--193 +\TU/CharisSIL(1)/m/n/8 re-search. Cur-rently, there have been only two clin-i-ca +l tri-als + [] + + +Underfull \hbox (badness 1132) in paragraph at lines 194--194 +\TU/CharisSIL(1)/m/n/8 sources, struc-tural clas-si-fi-ca-tions, and the var-i-o +us mech-a-nisms + [] + + +Underfull \hbox (badness 5954) in paragraph at lines 201--201 +\TU/CharisSIL(1)/m/n/8 of liver fi-bro-sis through PD-1 reg-u-lat-ing NK cell fu +nc-tion + [] + + +Underfull \hbox (badness 1533) in paragraph at lines 201--201 +\TU/CharisSIL(1)/m/n/8 Nat-u-ral Sci-ence Foun-da-tion of Shan-dong Province +“As-tra-galus + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 1527) in paragraph at lines 205--205 +[]\TU/CharisSIL(1)/m/n/8 COPD, chronic ob-struc-tive pul-monary dis-ease; CS, ci +garette + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 1418) in paragraph at lines 205--205 +\TU/CharisSIL(1)/m/n/8 growth factor-β; IL-6, interleukin-6; IL-1β, interleuki +n-1 beta; + [] + + +Underfull \hbox (badness 1436) in paragraph at lines 205--205 +\TU/CharisSIL(1)/m/n/8 2-related fac-tor 2; CXCL, C-X-C mo-tif chemokine lig-and +; NE, + [] + + +Underfull \hbox (badness 3375) in paragraph at lines 205--205 +\TU/CharisSIL(1)/m/n/8 re-cep-tor 4; JNK, c-Jun N-terminal ki-nase; SOD, su-per- +ox-ide + [] + + +Underfull \hbox (badness 1796) in paragraph at lines 205--205 +\TU/CharisSIL(1)/m/n/8 dis-mu-tase; GSH, glu-tathione; GSH-Px, glu-tathione per- +ox-i-dase; + [] + +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! + +Underfull \hbox (badness 2744) in paragraph at lines 205--205 +\TU/CharisSIL(1)/m/n/8 ep-ithe-lial cells; TLRs, toll-like re-cep-tors; IRAK, in +terleukin-1 + [] + + +Underfull \hbox (badness 1484) in paragraph at lines 205--205 +\TU/CharisSIL(1)/m/n/8 ox-i-dase 4; TIMP, tis-sue in-hibitors of met-al-lo-pro-t +einase; EMT, + [] + + +Underfull \hbox (badness 2065) in paragraph at lines 207--207 +[]\TU/CharisSIL(1)/m/n/8 Shi PL, Zhang GX, Wang PY, Liu ZQ, Zheng BQ. Nat-u-ral + [] + + +Underfull \hbox (badness 1112) in paragraph at lines 207--207 +\TU/CharisSIL(1)/m/n/8 flavonoids for the treat-ment of chronic ob-struc-tive pu +l-monary [] -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! [10 -Missing character: There is no 执 (U+6267) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 行 (U+884C) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 附 (U+9644) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 表 (U+8868) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 程 (U+7A0B) in font [lmroman8-regular]:+tlig;! -Missing character: There is no 序 (U+5E8F) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! -Missing character: There is no β (U+03B2) in font [lmroman8-regular]:+tlig;! +Missing character: There is no 执 (U+6267) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 行 (U+884C) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 附 (U+9644) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 表 (U+8868) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 程 (U+7A0B) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no 序 (U+5E8F) in font "name:Charis SIL:mode=node;s +cript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! +Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc +ript=latn;language=dflt;"! ] File: ./image/zipimg67aea6fbb71406.png Graphic file (type png) Package luatex.def Info: ./image/zipimg67aea6fbb71406.png used on input line 2 -12. +11. (luatex.def) Requested size: 439.93333pt x 267.80168pt. - [11 -Missing character: There is no κ (U+03BA) in font [lmroman8-regular]:+tlig;! -Missing character: There is no α (U+03B1) in font [lmroman8-regular]:+tlig;! -] -Underfull \hbox (badness 4279) in paragraph at lines 220--220 + [11] +Underfull \hbox (badness 4279) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 causes of death. Cause spe-cific mor-tal-ity 2000–2019. [] -Underfull \hbox (badness 1642) in paragraph at lines 220--220 +Underfull \hbox (badness 1642) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Math-ers CD, Lon-car D. Pro-jec-tions of global mor-tal -ity [] -Underfull \hbox (badness 1365) in paragraph at lines 220--220 +Underfull \hbox (badness 1365) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 and bur-den of dis-ease from 2002 to 2030. \TU/CharisSIL (0)/m/it/8 PLoS Med\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Chris-ten-son SA, Smith BM, Bafad-hel M, et al. [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Chronic ob-struc-tive pul-monary dis-ease. \TU/CharisSIL (0)/m/it/8 Lancet\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 4291) in paragraph at lines 220--220 +Underfull \hbox (badness 4291) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 treat-ment, pre-ven-tion and dis-ease im-pact. \TU/Chari sSIL(0)/m/it/8 Respirol-ogy\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 4981) in paragraph at lines 220--220 +Underfull \hbox (badness 4981) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 van der Toorn M, Reza-yat D, Kauff-man HF, et al. [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Lipid-soluble com-po-nents in cigarette smoke in-duce [] -Underfull \hbox (badness 1231) in paragraph at lines 220--220 +Underfull \hbox (badness 1231) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 mi-to-chon-drial pro-duc-tion of re-ac-tive oxy-gen speci es in [] -Underfull \hbox (badness 1137) in paragraph at lines 220--220 +Underfull \hbox (badness 1137) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 in-hibitors on air-way mucin: Molec-u-lar in-sight into the [] -Underfull \hbox (badness 1062) in paragraph at lines 220--220 +Underfull \hbox (badness 1062) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 ther-a-peu-tic po-ten-tial tar-get-ing MUC5AC ex-pres-sio n and [] -Underfull \hbox (badness 1533) in paragraph at lines 220--220 +Underfull \hbox (badness 1533) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Shih YM, Chang YJ, Cooke MS, et al. Alky-lat-ing and [] -Underfull \hbox (badness 1038) in paragraph at lines 220--220 +Underfull \hbox (badness 1038) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Lee G, Walser TC, Du-bi-nett SM. Chronic in-flam-ma-tio n, [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 To Y, Ito K, Kizawa Y, et al. Tar-get-ing [] -Underfull \hbox (badness 2856) in paragraph at lines 220--220 +Underfull \hbox (badness 2856) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Phosphoinositide-3-Kinase-δ with Theo-phylline Re-verses [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Cor-ti-cos-teroid In-sen-si-tiv-ity in Chronic Ob-struc-t ive [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Pul-monary Dis-ease. \TU/CharisSIL(0)/m/it/8 Am J Respir Crit Care Med\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 1552) in paragraph at lines 220--220 +Underfull \hbox (badness 1552) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Yao HW, Rah-man I. Role of hi-s-tone deacety-lase 2 in [] [12] -Underfull \hbox (badness 6125) in paragraph at lines 220--220 +Underfull \hbox (badness 6125) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Cheng SE, Lee IT, Lin CC, et al. Cigarette smoke [] -Underfull \hbox (badness 2142) in paragraph at lines 220--220 +Underfull \hbox (badness 2142) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Brus-selle GG, Joos GF, Bracke KR. New in-sights into [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 met-al-lo-pro-teinases in the de-vel-op-ment of air-way [] -Underfull \hbox (badness 6001) in paragraph at lines 220--220 +Underfull \hbox (badness 6001) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 in-flam-ma-tion and re-mod-el-ing. \TU/CharisSIL(0)/m/it /8 Braz J Med Biol Res\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 2237) in paragraph at lines 220--220 +Underfull \hbox (badness 2237) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Burgel PR. Roles of epi-der-mal growth fac-tor re-cep-t or [] -Underfull \hbox (badness 4366) in paragraph at lines 220--220 +Underfull \hbox (badness 4366) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Shao MXG, Nakanaga T, Nadel JA. Cigarette smoke [] -Underfull \hbox (badness 1603) in paragraph at lines 220--220 +Underfull \hbox (badness 1603) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 factor-α-converting en-zyme in hu-man air-way ep-ithe-li al [] -Underfull \hbox (badness 2608) in paragraph at lines 220--220 +Underfull \hbox (badness 2608) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 (NCI-H292) cells. \TU/CharisSIL(0)/m/it/8 Am J Phys-iol Lung Cell Mol Phys-iol\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 2318) in paragraph at lines 220--220 +Underfull \hbox (badness 2318) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Chen P, Parks WC. Role of ma-trix met-al-lo-pro-teinase s [] -Underfull \hbox (badness 6380) in paragraph at lines 220--220 +Underfull \hbox (badness 6380) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Al‐Tamari HM, Dabral S, Schmall A, et al. FoxO3 [] -Underfull \hbox (badness 6708) in paragraph at lines 220--220 +Underfull \hbox (badness 6708) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 an im-por-tant player in fi-bro-ge-n-e-sis and ther-a-peu -tic [] -Underfull \hbox (badness 1360) in paragraph at lines 220--220 +Underfull \hbox (badness 1360) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Wang H, Yang T, Wang T, et al. Phloretin at-ten-u-ates [] -Underfull \hbox (badness 1755) in paragraph at lines 220--220 +Underfull \hbox (badness 1755) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 by cigarette smoke. \TU/CharisSIL(0)/m/it/8 Int Im-munoph ar-ma-col\TU/CharisSIL(1)/m/n/8 . 2018;55:112. [] -Underfull \hbox (badness 1888) in paragraph at lines 220--220 +Underfull \hbox (badness 1888) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Birru RL, Bein K, Bon-darchuk N, et al. An-timi-cro-bia l [] -Underfull \hbox (badness 7944) in paragraph at lines 220--220 +Underfull \hbox (badness 7944) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 and Anti-Inflammatory Ac-tiv-ity of Ap-ple Polyphe-nol [] Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1418) in paragraph at lines 220--220 +Underfull \hbox (badness 1418) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Yu D, Liu X, Zhang G, et al. Isoliquir-it-i-genin In-hi bits [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Cigarette Smoke-Induced COPD by At-ten-u-at-ing [] -Underfull \hbox (badness 2799) in paragraph at lines 220--220 +Underfull \hbox (badness 2799) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 In-flam-ma-tion and Ox-ida-tive Stress via the Reg-u-la-t ion [] @@ -3326,68 +3742,68 @@ ion Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1189) in paragraph at lines 220--220 +Underfull \hbox (badness 1189) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Sup-presses Platelet Ac-ti-vat-ing Factor-Induced Ac-ti-v a-tion [] -Underfull \hbox (badness 4316) in paragraph at lines 220--220 +Underfull \hbox (badness 4316) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Jin M, Xue C, Wang Y, et al. Pro-tec-tive Ef-fect of [] -Underfull \hbox (badness 1052) in paragraph at lines 220--220 +Underfull \hbox (badness 1052) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Ob-struc-tive Pul-monary Dis-ease Rats. \TU/CharisSIL(0) /m/it/8 Chin J In-tegr Med\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 1490) in paragraph at lines 220--220 +Underfull \hbox (badness 1490) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Liu L, Zhang Y, Wang L, et al. Scutel-larein al-le-vi-a tes [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 of fer-rop-to-sis by chelat-ing iron and in-ter-act-ing [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 with arachi-do-nate 15‐lipoxy-ge-nase. \TU/CharisSIL(0 )/m/it/8 Phy-tother Res\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 2865) in paragraph at lines 220--220 +Underfull \hbox (badness 2865) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Gane-san S, Faris AN, Com-stock AT, et al. Quercetin [] -Underfull \hbox (badness 1377) in paragraph at lines 220--220 +Underfull \hbox (badness 1377) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 pre-vents pro-gres-sion of dis-ease in elas-tase/LPS-expo sed [] -Underfull \hbox (badness 5908) in paragraph at lines 220--220 +Underfull \hbox (badness 5908) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Mi-tani A, Azam A, Vup-pusetty C, et al. Quercetin [] -Underfull \hbox (badness 1552) in paragraph at lines 220--220 +Underfull \hbox (badness 1552) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 re-stores cor-ti-cos-teroid sen-si-tiv-ity in cells from pa-tients [] -Underfull \hbox (badness 1515) in paragraph at lines 220--220 +Underfull \hbox (badness 1515) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 rhinovirus-induced pro-gres-sion of lung dis-ease in mice [] -Underfull \hbox (badness 1205) in paragraph at lines 220--220 +Underfull \hbox (badness 1205) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Caused by Ex-po-sure to Cigarette Smoke in Male Mice. [] @@ -3398,14 +3814,14 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Lee S, Ro H, In HJ, et al. Fisetin in-hibits [] Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1178) in paragraph at lines 220--220 +Underfull \hbox (badness 1178) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 and in-flam-ma-tion in Wis-tar rat lungs. \TU/CharisSIL( 0)/m/it/8 J Food Biochem\TU/CharisSIL(1)/m/n/8 . [] @@ -3421,41 +3837,41 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 2452) in paragraph at lines 220--220 +Underfull \hbox (badness 2452) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Chen M, Chen Z, Huang D, et al. Myricetin in-hibits [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 TNF-α-induced in-flam-ma-tion in A549 cells via [] Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 the SIRT1/NF-κ󰀀B path-way. \TU/CharisSIL(0)/m/it/8 Pu lm Phar-ma-col Ther\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 4416) in paragraph at lines 220--220 +Underfull \hbox (badness 4416) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Lee H, Jung KH, Lee H, et al. Cas-ticin, an ac-tive [] -Underfull \hbox (badness 1264) in paragraph at lines 220--220 +Underfull \hbox (badness 1264) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 com-pound iso-lated from Vi-tex Fruc-tus, ame-lio-rates the [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Dys-func-tion and At-ten-u-ates Ox-ida-tive Stress and [] -Underfull \hbox (badness 6893) in paragraph at lines 220--220 +Underfull \hbox (badness 6893) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 In-flam-ma-tion via In-hi-bi-tion of NF-ĸB in a Chronic [] @@ -3464,20 +3880,20 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1502) in paragraph at lines 220--220 +Underfull \hbox (badness 1502) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Lu LJ, Tian H, Zheng Y, et al. Ef-fects of cas-ticin on [] -Underfull \hbox (badness 6510) in paragraph at lines 220--220 +Underfull \hbox (badness 6510) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Lipopolysaccharide-induced BEAS-2B cell dam-age and [] Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 NF-κ󰀀B-KEAP1-NRF2/ARE path-way. \TU/CharisSIL(0)/m/i t/8 Chin J Im-munol\TU/CharisSIL(1)/m/n/8 . [] @@ -3487,36 +3903,36 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 5231) in paragraph at lines 220--220 +Underfull \hbox (badness 5231) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Li MF, Wang HF, Lu Y, et al. Lu-te-olin sup-presses [] Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 NF‐κ󰀀B sig-nal-ing path-way. \TU/CharisSIL(0)/m/it /8 Im-mun In-flamm Dis\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 5985) in paragraph at lines 220--220 +Underfull \hbox (badness 5985) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Zhou L, Jian T, Wan Y, et al. Lu-te-olin Al-le-vi-ates [] -Underfull \hbox (badness 1226) in paragraph at lines 220--220 +Underfull \hbox (badness 1226) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 and CYP2A13/NRF2 Sig-nal-ing Path-ways. \TU/CharisSIL(0) /m/it/8 Int J Mol Sci\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 2310) in paragraph at lines 220--220 +Underfull \hbox (badness 2310) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Luo YL, Zhang CC, Li PB, et al. Naringin at-ten-u-ates [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 in-duced by cigarette smoke. \TU/CharisSIL(0)/m/it/8 Int Im-munophar-ma-col\TU/CharisSIL(1)/m/n/8 . [] @@ -3525,12 +3941,12 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 2384) in paragraph at lines 220--220 +Underfull \hbox (badness 2384) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Chen Z, Wu H, Fan W, et al. Narin-genin sup-presses [] -Underfull \hbox (badness 1009) in paragraph at lines 220--220 +Underfull \hbox (badness 1009) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 BEAS-2B-derived ex-tra-cel-lu-lar vesic-u-lar car-goes di s-or-der [] @@ -3538,12 +3954,12 @@ s-or-der Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1406) in paragraph at lines 220--220 +Underfull \hbox (badness 1406) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Wang S, He N, Xing H, et al. Func-tion of hes-peridin [] -Underfull \hbox (badness 1838) in paragraph at lines 220--220 +Underfull \hbox (badness 1838) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 al-le-vi-at-ing in-flam-ma-tion and ox-ida-tive stress re -sponses [] @@ -3551,29 +3967,29 @@ Underfull \hbox (badness 1838) in paragraph at lines 220--220 Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1377) in paragraph at lines 220--220 +Underfull \hbox (badness 1377) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 of chronic ob-struc-tive pul-monary dis-ease by ac-ti-vat -ing [] -Underfull \hbox (badness 2293) in paragraph at lines 220--220 +Underfull \hbox (badness 2293) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Nrf2-mediated path-way. \TU/CharisSIL(0)/m/it/8 Phy-tomed icine\TU/CharisSIL(1)/m/n/8 . 2022;96:153894. [] -Underfull \hbox (badness 8132) in paragraph at lines 220--220 +Underfull \hbox (badness 8132) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Liu X, Ma Y, Luo L, et al. Tax-i-folin ame-lio-rates [] -Underfull \hbox (badness 2460) in paragraph at lines 220--220 +Underfull \hbox (badness 2460) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 cigarette smoke-induced chronic ob-struc-tive pul-monary [] -Underfull \hbox (badness 2753) in paragraph at lines 220--220 +Underfull \hbox (badness 2753) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 dis-ease via in-hibit-ing in-flam-ma-tion and apop-to-sis . \TU/CharisSIL(0)/m/it/8 Int [] @@ -3581,30 +3997,30 @@ Underfull \hbox (badness 2753) in paragraph at lines 220--220 Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1533) in paragraph at lines 220--220 +Underfull \hbox (badness 1533) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Zeng LX, Dong JC, Yu WQ, et al. Baicalin at-ten-u-ates [] Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 2111) in paragraph at lines 220--220 +Underfull \hbox (badness 2111) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 and in vitro: A pos-si-ble role for HDAC2 ac-tiv-ity. \T U/CharisSIL(0)/m/it/8 Int [] -Underfull \hbox (badness 3989) in paragraph at lines 220--220 +Underfull \hbox (badness 3989) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Wang G, Mo-ham-mad-tur-sun N, Lv Y, et al. Baicalin [] -Underfull \hbox (badness 2556) in paragraph at lines 220--220 +Underfull \hbox (badness 2556) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Ex-erts Anti-Airway In-flam-ma-tion and Anti-Remodelling [] -Underfull \hbox (badness 7832) in paragraph at lines 220--220 +Underfull \hbox (badness 7832) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 ob-struc-tive pul-monary dis-ease through reg-u-la-tion of [] @@ -3616,13 +4032,13 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 6842) in paragraph at lines 220--220 +Underfull \hbox (badness 6842) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 HDAC2/NF-κ󰀀B/PAI-1 sig-nalling. \TU/CharisSIL(0)/m/i t/8 Pulm Phar-ma-col Ther\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 2671) in paragraph at lines 220--220 +Underfull \hbox (badness 2671) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 miR-4451ef-fect on lipopolysaccharide-induced apop-to-sis [] @@ -3632,7 +4048,7 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 2790) in paragraph at lines 220--220 +Underfull \hbox (badness 2790) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 sig-nal-ing path-way. \TU/CharisSIL(0)/m/it/8 J Army Med Univ\TU/CharisSIL(1)/m/n/8 . 2022;44(5):441. [] @@ -3641,7 +4057,7 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 2913) in paragraph at lines 220--220 +Underfull \hbox (badness 2913) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Ju J, Li Z, Shi Q. Baicalin In-hibits In-flam-ma-tion in [] @@ -3649,45 +4065,45 @@ in Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1953) in paragraph at lines 220--220 +Underfull \hbox (badness 1953) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 TLR2/MYD88/NF-κ󰀀Bp65 Sig-nal-ing Path-way. \TU/Chari sSIL(0)/m/it/8 Evid Based [] -Underfull \hbox (badness 2245) in paragraph at lines 220--220 +Underfull \hbox (badness 2245) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Jing X, Huo J, Li L, et al. Baicalin Re-lieves Air-way [] -Underfull \hbox (badness 2103) in paragraph at lines 220--220 +Underfull \hbox (badness 2103) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Kim YH, Kang MK, Lee EJ, et al. As-tra-galin In-hibits [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Cigarette Smoke-Induced Pul-monary Throm-bo-sis and [] -Underfull \hbox (badness 1184) in paragraph at lines 220--220 +Underfull \hbox (badness 1184) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 cigarette smoke ex-tract. \TU/CharisSIL(0)/m/it/8 Exp The r Med\TU/CharisSIL(1)/m/n/8 . 2020;20(1):283. [] -Underfull \hbox (badness 7291) in paragraph at lines 220--220 +Underfull \hbox (badness 7291) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 of Icariin Com-bined with No-biletin against Chronic [] -Underfull \hbox (badness 1199) in paragraph at lines 220--220 +Underfull \hbox (badness 1199) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Ob-struc-tive Pul-monary Dis-eases. \TU/CharisSIL(0)/m/i t/8 Evid Based Com-ple-ment [] -Underfull \hbox (badness 4927) in paragraph at lines 220--220 +Underfull \hbox (badness 4927) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Li QP, Zhang HY, Yan XP, et al. Up-regulation of [] @@ -3711,164 +4127,164 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! ] -Underfull \hbox (badness 2310) in paragraph at lines 220--220 +Underfull \hbox (badness 2310) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Song WY, Song YS, Ryu HW, et al. Tilianin In-hibits [] -Underfull \hbox (badness 1859) in paragraph at lines 220--220 +Underfull \hbox (badness 1859) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 MUC5AC Ex-pres-sion Me-di-ated Via Down-Regulation of [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 EGFR-MEK-ERK-Sp1 Sig-nal-ing Path-way in NCI-H292 [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Med-i-ca-tion of Gly-cyrrhiza glabra, Agas-tache ru-gosa [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Con-tain-ing Gly-cyrrhizic Acid, Tilianin In-hibits [] -Underfull \hbox (badness 6775) in paragraph at lines 220--220 +Underfull \hbox (badness 6775) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Neu-trophilic Lung In-flam-ma-tion by Af-fect-ing CXCL2, [] -Underfull \hbox (badness 3690) in paragraph at lines 220--220 +Underfull \hbox (badness 3690) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 biochanin A. \TU/CharisSIL(0)/m/it/8 Eco-tox-i-col En-v-i -ron Saf\TU/CharisSIL(1)/m/n/8 . 2020;202:110878. [] -Underfull \hbox (badness 3907) in paragraph at lines 220--220 +Underfull \hbox (badness 3907) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Wang L, Jiang W, Wang J, et al. Puer-arin in-hibits [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 FUNDC1-mediated mi-to-chon-drial au-tophagy and [] -Underfull \hbox (badness 6493) in paragraph at lines 220--220 +Underfull \hbox (badness 6493) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 CSE-induced apop-to-sis of hu-man bronchial ep-ithe-lial [] -Underfull \hbox (badness 4108) in paragraph at lines 220--220 +Underfull \hbox (badness 4108) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Pan XJ, Fan JQ, Xia GQ. Puer-arin in-hibits alve-o-lar [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 pathway-mediated mi-tophagy. \TU/CharisSIL(0)/m/it/8 Chin J Patho-phys-iol\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Li XM, Jiang XH, Zeng RH, et al. For-mononetin [] -Underfull \hbox (badness 3668) in paragraph at lines 220--220 +Underfull \hbox (badness 3668) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 at-ten-u-ates cigarette smoke-induced COPD in mice by [] -Underfull \hbox (badness 1558) in paragraph at lines 220--220 +Underfull \hbox (badness 1558) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 sup-press-ing in-flam-ma-tion, en-do-plas-mic retic-u-lum stress, [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 and AKT/mTOR sig-nal-ing path-ways. \TU/CharisSIL(0)/m/i t/8 Phy-tother Res\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 3568) in paragraph at lines 220--220 +Underfull \hbox (badness 3568) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Park JW, Shin NR, Shin IS, et al. Sili-b-inin In-hibits [] -Underfull \hbox (badness 4647) in paragraph at lines 220--220 +Underfull \hbox (badness 4647) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Ko JW, Shin NR, Park SH, et al. Sili-b-inin in-hibits [] -Underfull \hbox (badness 2205) in paragraph at lines 220--220 +Underfull \hbox (badness 2205) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 the fi-brotic re-sponses in-duced by cigarette smoke via [] -Underfull \hbox (badness 1303) in paragraph at lines 220--220 +Underfull \hbox (badness 1303) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 sup-pres-sion of TGF-β1/Smad 2/3 sig-nal-ing. \TU/Chari sSIL(0)/m/it/8 Food Chem [] -Underfull \hbox (badness 4739) in paragraph at lines 220--220 +Underfull \hbox (badness 4739) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Li DD, Xu D, Wang T, et al. Sily-marin At-ten-u-ates [] -Underfull \hbox (badness 6859) in paragraph at lines 220--220 +Underfull \hbox (badness 6859) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 smoke extract-induced in-flam-ma-tion via si-mul-ta-ne-ou s [] -Underfull \hbox (badness 1394) in paragraph at lines 220--220 +Underfull \hbox (badness 1394) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 the c/EBPβ sig-nal-ing path-way and CCL2 ex-pres-sion. \TU/CharisSIL(0)/m/it/8 J [] -Underfull \hbox (badness 3954) in paragraph at lines 220--220 +Underfull \hbox (badness 3954) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Chen XL, Geng DS. Ef-fect of To-tal Flavonoids from [] -Underfull \hbox (badness 2460) in paragraph at lines 220--220 +Underfull \hbox (badness 2460) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Ren QC, Li XH, Li QY, et al. To-tal flavonoids from [] -Underfull \hbox (badness 7221) in paragraph at lines 220--220 +Underfull \hbox (badness 7221) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 sea buck-thorn ame-lio-rates lipopolysac-cha-ride/cigaret te [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 smoke‐in-duced air-way in-flam-ma-tion. \TU/CharisSIL( 0)/m/it/8 Phy-tother Res\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 1377) in paragraph at lines 220--220 +Underfull \hbox (badness 1377) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 of To-tal Flavonoids from Scutel-laria Baicalen-sis Georg i [] -Underfull \hbox (badness 1067) in paragraph at lines 220--220 +Underfull \hbox (badness 1067) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 in the In-flam-ma-tion and Ox-ida-tive Stress in Rats wit h [] -Underfull \hbox (badness 8113) in paragraph at lines 220--220 +Underfull \hbox (badness 8113) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Chronic Ob-struc-tive Pul-monary Dis-ease. \TU/CharisSIL (0)/m/it/8 Chin Pharm\TU/CharisSIL(1)/m/n/8 . [] @@ -3876,7 +4292,7 @@ Underfull \hbox (badness 8113) in paragraph at lines 220--220 Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1082) in paragraph at lines 220--220 +Underfull \hbox (badness 1082) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 flavonoids of Trol-lius al-taicus on a chronic ob-struc-t ive [] @@ -3884,28 +4300,28 @@ ive Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 4168) in paragraph at lines 220--220 +Underfull \hbox (badness 4168) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Van Ee-den SF, Sin DD. Ox-ida-tive Stress in Chronic [] -Underfull \hbox (badness 3148) in paragraph at lines 220--220 +Underfull \hbox (badness 3148) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Ob-struc-tive Pul-monary Dis-ease: A Lung and Sys-temic [] -Underfull \hbox (badness 1939) in paragraph at lines 220--220 +Underfull \hbox (badness 1939) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Suzuki M, Bet-suyaku T, Ito Y, et al. Down-Regulated [] -Underfull \hbox (badness 1596) in paragraph at lines 220--220 +Underfull \hbox (badness 1596) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Eu-rlings IMJ, Rey-naert NL, van de We-ter-ing C, et al . [] -Underfull \hbox (badness 3271) in paragraph at lines 220--220 +Underfull \hbox (badness 3271) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Aug-ments Neu-trophil Cy-to-toxic Po-ten-tial via Se-lec- tive [] @@ -3917,7 +4333,7 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1237) in paragraph at lines 220--220 +Underfull \hbox (badness 1237) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 and IKK func-tion. \TU/CharisSIL(0)/m/it/8 Nat Rev Mol Ce ll Biol\TU/CharisSIL(1)/m/n/8 . 2007;8(1):49. [] @@ -3933,141 +4349,141 @@ ript=latn;language=dflt;"! Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 1728) in paragraph at lines 220--220 +Underfull \hbox (badness 1728) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Lora JM, Zhang DM, Liao SM, et al. Tu-mor Necro-sis [] Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! -Underfull \hbox (badness 7397) in paragraph at lines 220--220 +Underfull \hbox (badness 7397) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Takeuchi O, Takeda K, Hoshino K, et al. Cel-lu-lar [] -Underfull \hbox (badness 1546) in paragraph at lines 220--220 +Underfull \hbox (badness 1546) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Ra-jen-dra-sozhan S, Yang SR, Kin-nula VL, et al. SIRT1 , [] -Underfull \hbox (badness 2635) in paragraph at lines 220--220 +Underfull \hbox (badness 2635) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Dis-ease. \TU/CharisSIL(0)/m/it/8 Am J Respir Crit Care Med\TU/CharisSIL(1)/m/n/8 . 2008;177(8):861. [] -Underfull \hbox (badness 6526) in paragraph at lines 220--220 +Underfull \hbox (badness 6526) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 senes-cence in mice. \TU/CharisSIL(0)/m/it/8 J Clin In-ve st\TU/CharisSIL(1)/m/n/8 . 2012;122(6):2032. [] -Underfull \hbox (badness 1681) in paragraph at lines 220--220 +Underfull \hbox (badness 1681) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 FEV1 in COPD pa-tients. \TU/CharisSIL(0)/m/it/8 Med Sci Monit\TU/CharisSIL(1)/m/n/8 . 2013;19:1229. [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 of Non-ty-peable Haemophilus in-fluen-zae Up-regulate [] -Underfull \hbox (badness 6961) in paragraph at lines 220--220 +Underfull \hbox (badness 6961) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Phos-pho-inosi-tide 3-Kinase-Akt Path-way. \TU/CharisSIL (0)/m/it/8 J Biol Chem\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 3281) in paragraph at lines 220--220 +Underfull \hbox (badness 3281) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 and af-ter Treat-ment of AE-COPD, a Lon-gi-tu-di-nal and [] -Underfull \hbox (badness 4001) in paragraph at lines 220--220 +Underfull \hbox (badness 4001) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Mah-mood M, So-hal SS, Shukla SD, et al. Ep-ithe-lial [] -Underfull \hbox (badness 1742) in paragraph at lines 220--220 +Underfull \hbox (badness 1742) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 mes-enchy-mal tran-si-tion in smok-ers: large ver-sus sma ll [] -Underfull \hbox (badness 1248) in paragraph at lines 220--220 +Underfull \hbox (badness 1248) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 pro-file of ma-trix met-al-lo-pro-teinases (MMPs) and tis -sue [] -Underfull \hbox (badness 3108) in paragraph at lines 220--220 +Underfull \hbox (badness 3108) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 An-tunes MA, Rocco PRM. Elastase-induced pul-monary [] -Underfull \hbox (badness 2343) in paragraph at lines 220--220 +Underfull \hbox (badness 2343) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 key to EMT‐as-so-ci-ated COPD patho-gen-e-sis. \TU/Cha risSIL(0)/m/it/8 Respirol-ogy\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 1789) in paragraph at lines 220--220 +Underfull \hbox (badness 1789) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Wang Y, Xia S. Re-la-tion-ship Be-tween ACSL4-Mediated [] -Underfull \hbox (badness 6094) in paragraph at lines 220--220 +Underfull \hbox (badness 6094) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Liu Z, Li C, Li M, et al. The sub-chronic tox-i-c-ity [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 of hy-drox-ysaf-flor yel-low A of 90 days re-peat-edly [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 in-traperi-toneal in-jec-tions in rats. \TU/CharisSIL(0) /m/it/8 Tox-i-col-ogy\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 3019) in paragraph at lines 220--220 +Underfull \hbox (badness 3019) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 a sys-tem-atic re-view and Meta-analysis of ran-dom-ized [] -Underfull \hbox (badness 6236) in paragraph at lines 220--220 +Underfull \hbox (badness 6236) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 con-trolled tri-als. \TU/CharisSIL(0)/m/it/8 J Tra-dit Ch in Med\TU/CharisSIL(1)/m/n/8 . 2014;34(4):401. [] -Underfull \hbox (badness 4752) in paragraph at lines 220--220 +Underfull \hbox (badness 4752) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 across Dis-ease Sever-ity. \TU/CharisSIL(0)/m/it/8 Am J Respir Crit Care Med\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 6236) in paragraph at lines 220--220 +Underfull \hbox (badness 6236) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Yang IA, Jenk-ins CR, Salvi SS. Chronic ob-struc-tive [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 pul-monary dis-ease in never-smokers: risk fac-tors, [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 patho-gen-e-sis, and im-pli-ca-tions for pre-ven-tion and [] -Underfull \hbox (badness 5359) in paragraph at lines 220--220 +Underfull \hbox (badness 5359) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Mart MF, Pee-bles RS Jr. Asthma-chronic ob-struc-tive [] @@ -4075,189 +4491,189 @@ Underfull \hbox (badness 5359) in paragraph at lines 220--220 Missing character: There is no κ (U+03BA) in font "name:Charis SIL:mode=node;sc ript=latn;language=dflt;"! ] -Underfull \hbox (badness 1931) in paragraph at lines 220--220 +Underfull \hbox (badness 1931) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Shah AJ, Quek E, Alqah-tani JS, et al. Car-dio-vas-cu-l ar [] -Underfull \hbox (badness 1546) in paragraph at lines 220--220 +Underfull \hbox (badness 1546) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 A sys-tem-atic re-view and meta-analysis. \TU/CharisSIL( 0)/m/it/8 Sleep Med Rev\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Brightling C, Green-ing N. Air-way in-flam-ma-tion in [] -Underfull \hbox (badness 5681) in paragraph at lines 220--220 +Underfull \hbox (badness 5681) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 COPD: progress to pre-ci-sion medicine. \TU/CharisSIL(0) /m/it/8 Eur Respir J\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 2080) in paragraph at lines 220--220 +Underfull \hbox (badness 2080) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Barnes PJ, Bur-ney PGJ, Sil-ver-man EK, et al. Chronic [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 ob-struc-tive pul-monary dis-ease. \TU/CharisSIL(0)/m/it /8 Nat Rev Dis Primers\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 4072) in paragraph at lines 220--220 +Underfull \hbox (badness 4072) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Burgess JK, Weiss DJ, Westergren-Thorsson G, et al. [] -Underfull \hbox (badness 3568) in paragraph at lines 220--220 +Underfull \hbox (badness 3568) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Feng YY, Li M, Yangzhong XT, et al. Py-rop-to-sis in [] -Underfull \hbox (badness 1424) in paragraph at lines 220--220 +Underfull \hbox (badness 1424) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 pul-monary dis-ease. \TU/CharisSIL(0)/m/it/8 J Ethnophar- ma-col\TU/CharisSIL(1)/m/n/8 . 2023;307:116229. [] -Underfull \hbox (badness 6461) in paragraph at lines 220--220 +Underfull \hbox (badness 6461) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 McGuin-ness A, Sapey E. Ox-ida-tive Stress in COPD: [] -Underfull \hbox (badness 1596) in paragraph at lines 220--220 +Underfull \hbox (badness 1596) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Lung In-jury in Chronic Ob-struc-tive Pul-monary Dis-ease [] -Underfull \hbox (badness 1127) in paragraph at lines 220--220 +Underfull \hbox (badness 1127) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 mark-ers in hu-man bron-choalve-o-lar lavage fluid ex-hib it [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Wang R, Ramos C, Joshi I, et al. Hu-man lung [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 myofibroblast-derived in-duc-ers of alve-o-lar ep-ithe-li al [] -Underfull \hbox (badness 4556) in paragraph at lines 220--220 +Underfull \hbox (badness 4556) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 is a dif-fusible paracrine sig-nal for the in-duc-tion of [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Adler KB, Holden-Stauffer WJ, Re-pine JE. Oxy-gen [] -Underfull \hbox (badness 4391) in paragraph at lines 220--220 +Underfull \hbox (badness 4391) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 metabo-lites stim-u-late re-lease of high-molecular-weigh t [] -Underfull \hbox (badness 3108) in paragraph at lines 220--220 +Underfull \hbox (badness 3108) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 gly-co-con-ju-gates by cell and or-gan cul-tures of ro-de nt [] -Underfull \hbox (badness 1655) in paragraph at lines 220--220 +Underfull \hbox (badness 1655) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Bor-mann T, Maus R, Stolper J, et al. Role of ma-trix [] -Underfull \hbox (badness 4403) in paragraph at lines 220--220 +Underfull \hbox (badness 4403) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Dimic-Janjic S, Hoda MA, Milenkovic B, et al. The [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Hod-gin KS, Dono-van EK, Kekes-Szabo S, et al. A [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Placebo-Controlled, Pseudo-Randomized, Crossover [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Trial of Botan-i-cal Agents for Gulf War Ill-ness: [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Resver-a-trol (Poly-gonum cus-p-i-da-tum), Lu-te-olin, an d [] -Underfull \hbox (badness 3428) in paragraph at lines 220--220 +Underfull \hbox (badness 3428) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Re-bello CJ, Beyl RA, Ler-tora JJL, et al. Safety and [] -Underfull \hbox (badness 1484) in paragraph at lines 220--220 +Underfull \hbox (badness 1484) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 sin-gle‐as-cend-ing‐dose clin-i-cal trial. \TU/Chari sSIL(0)/m/it/8 Di-a-betes Obes Metab\TU/CharisSIL(1)/m/n/8 . [] [17] -Underfull \hbox (badness 3128) in paragraph at lines 220--220 +Underfull \hbox (badness 3128) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Mori-waki M, Kito K, Nak-a-gawa R, et al. Mu-ta-genic, [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 Acute, and Sub-chronic Tox-i-c-ity Stud-ies of the [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 EFSA Panel on Di-etetic Prod-ucts, Nu-tri-tion (NDA), [] -Underfull \hbox (badness 2158) in paragraph at lines 220--220 +Underfull \hbox (badness 2158) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 ex-tract from Dahurian Larch (Larix gmelinii). \TU/Chari sSIL(0)/m/it/8 EFSA J\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 10000) in paragraph at lines 220--220 +Underfull \hbox (badness 10000) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 par-tial phar-ma-co-dy-namic and ini-tial safety anal-y-s is [] -Underfull \hbox (badness 4366) in paragraph at lines 220--220 +Underfull \hbox (badness 4366) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 of (−)-epicatechin in healthy vol-un-teers. \TU/Charis SIL(0)/m/it/8 Food Funct\TU/CharisSIL(1)/m/n/8 . [] -Underfull \hbox (badness 3815) in paragraph at lines 220--220 +Underfull \hbox (badness 3815) in paragraph at lines 219--219 []\TU/CharisSIL(1)/m/n/8 Chen IJ, Liu CY, Chiu JP, et al. Ther-a-peu-tic ef-fect [] -Underfull \hbox (badness 1331) in paragraph at lines 220--220 +Underfull \hbox (badness 1331) in paragraph at lines 219--219 \TU/CharisSIL(1)/m/n/8 of high-dose green tea ex-tract on weight re-duc-tion: A [] @@ -4276,33 +4692,30 @@ Package logreq Info: Writing requests to 'article_3113.run.xml'. ) Here is how much of LuaTeX's memory you used: - 46662 strings out of 476081 - 195444,1977958 words of node,token memory allocated + 46659 strings out of 476081 + 244307,1977958 words of node,token memory allocated 896 words of node memory still in use: 6 hlist, 2 vlist, 2 rule, 2 glue, 4 kern, 1 glyph, 7 attribute, 133 glue_spec , 7 attribute_list, 2 write nodes - avail lists: 1:7,2:2164,3:1420,4:530,5:1564,6:100,7:20459,8:54,9:600,10:14,11 -:1867 - 67972 multiletter control sequences out of 65536+600000 - 124 fonts using 49026207 bytes + avail lists: 1:6,2:2164,3:1420,4:553,5:1565,6:100,7:21655,8:54,9:600,10:13,11 +:1873 + 67969 multiletter control sequences out of 65536+600000 + 122 fonts using 48762831 bytes 104i,7n,128p,2469b,1260s stack positions out of 10000i,1000n,20000p,200000b,200000s -Output written on article_3113.pdf (18 pages, 9562055 bytes). +:/texlive/2025/texmf-dist/fonts/opentype/public/lm-math/latinmodern-math.otf> +Output written on article_3113.pdf (18 pages, 9541428 bytes). -PDF statistics: 777 PDF objects out of 1000 (max. 8388607) - 687 compressed objects within 7 object streams +PDF statistics: 749 PDF objects out of 1000 (max. 8388607) + 671 compressed objects within 7 object streams 209 named destinations out of 1000 (max. 131072) 120 words of extra memory for PDF output out of 10000 (max. 100000000) diff --git a/article_3113.pdf b/article_3113.pdf index 47b9ea6..ce4d3aa 100644 Binary files a/article_3113.pdf and b/article_3113.pdf differ diff --git a/article_3113.synctex.gz b/article_3113.synctex.gz index 244d2a7..957ad24 100644 Binary files a/article_3113.synctex.gz and b/article_3113.synctex.gz differ diff --git a/texput.log b/texput.log index fcff968..5936d6c 100644 --- a/texput.log +++ b/texput.log @@ -1,4 +1,4 @@ -This is LuaHBTeX, Version 1.22.0 (TeX Live 2025) (format=lualatex 2025.11.6) 9 FEB 2026 16:13 +This is LuaHBTeX, Version 1.22.0 (TeX Live 2025) (format=lualatex 2025.11.6) 12 FEB 2026 11:23 restricted system commands enabled. **tmr-tex.tex diff --git a/tmr-tex.cls b/tmr-tex.cls index 4b78284..18e3ba3 100644 --- a/tmr-tex.cls +++ b/tmr-tex.cls @@ -29,7 +29,7 @@ \renewcommand{\scriptsize}{\fontsize{7}{8}\selectfont} \renewcommand{\footnotesize}{\fontsize{8}{9.5}\selectfont} \renewcommand{\small}{\fontsize{9}{10.5}\selectfont} -%\renewcommand{\normalsize}{\fontsize{10}{12}\selectfont} +%\renewcommand{\normalsize}{\fontsize{10}{11}\selectfont} \renewcommand{\normalsize}{\fontsize{8}{9.5}\selectfont} \renewcommand{\large}{\fontsize{12}{14}\selectfont} %\renewcommand{\Large}{\fontsize{14}{16}\selectfont} @@ -38,6 +38,7 @@ \renewcommand{\Huge}{\fontsize{25}{28}\selectfont} \newcommand{\xiaoliu}{\fontsize{9}{11}\selectfont} +\AtBeginDocument{\bodyfont} \definecolor{contentblue}{RGB}{0, 130, 170} @@ -429,7 +430,7 @@ \end{minipage} \hfill \begin{minipage}[t]{0.5\textwidth} - {\fontsize{12pt}{14.4pt}\itshape\textbf{Abstract}}\par + {\xiaoliu\itshape\textbf{Abstract}}\par \vspace{\cup@space@left@title} \cup@tmrabstract\par \vspace{1em} @@ -1469,19 +1470,19 @@ \renewcommand\subsection{\@startsection{subsection}{2}{\z@}% {-3.25ex\@plus -1ex \@minus -.2ex}% {0.2ex \@plus .2ex}% - {\large\bodyfont\sffamily\bfseries}} + {\xiaoliu\bodyfont\sffamily\bfseries}} \renewcommand\subsubsection{\@startsection{subsubsection}{3}{\z@}% {-3.25ex\@plus -1ex \@minus -.2ex}% {0.2ex \@plus .2ex}% {\bodyfont\sffamily\bfseries}} -%\renewcommand\paragraph{\@startsection{paragraph}{4}{\z@}% -% {3.25ex \@plus1ex \@minus.2ex}% -% {-1em}% -% {\bodyfont\sffamily}} -%\renewcommand\subparagraph{\@startsection{subparagraph}{5}{\parindent}% -% {3.25ex \@plus1ex \@minus .2ex}% -% {-1em}% -% {\bodyfont\sffamily}} +\renewcommand\paragraph{\@startsection{paragraph}{4}{\z@}% + {3.25ex \@plus1ex \@minus.2ex}% + {-1em}% + {\bodyfont\sffamily}} +\renewcommand\subparagraph{\@startsection{subparagraph}{5}{\parindent}% + {3.25ex \@plus1ex \@minus .2ex}% + {-1em}% + {\bodyfont\sffamily}} %%这一命令用于文本的悬挂缩进或特定格式化 %\def\@hangfrom#1{\setbox\@tempboxa\hbox{{#1}}% @@ -1604,6 +1605,7 @@ \appto{\affilfont}{\sffamily} \appto{\datesize}{\sffamily} \appto{\emailfont}{\sffamily} + \appto{\normalsize}{\sffamily} \def\ps@plain{ \renewcommand{\@oddhead}{ \sffamily